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1QE6

INTERLEUKIN-8 WITH AN ADDED DISULFIDE BETWEEN RESIDUES 5 AND 33 (L5C/H33C)

Functional Information from GO Data
ChainGOidnamespacecontents
A0001525biological_processangiogenesis
A0002237biological_processresponse to molecule of bacterial origin
A0005125molecular_functioncytokine activity
A0005153molecular_functioninterleukin-8 receptor binding
A0005515molecular_functionprotein binding
A0005576cellular_componentextracellular region
A0005615cellular_componentextracellular space
A0006935biological_processchemotaxis
A0006952biological_processdefense response
A0006954biological_processinflammatory response
A0006955biological_processimmune response
A0007165biological_processsignal transduction
A0007186biological_processG protein-coupled receptor signaling pathway
A0008009molecular_functionchemokine activity
A0008201molecular_functionheparin binding
A0008285biological_processnegative regulation of cell population proliferation
A0010628biological_processpositive regulation of gene expression
A0010629biological_processnegative regulation of gene expression
A0019722biological_processcalcium-mediated signaling
A0030155biological_processregulation of cell adhesion
A0030593biological_processneutrophil chemotaxis
A0031328biological_processpositive regulation of cellular biosynthetic process
A0031623biological_processreceptor internalization
A0034976biological_processresponse to endoplasmic reticulum stress
A0035556biological_processintracellular signal transduction
A0042119biological_processneutrophil activation
A0044344biological_processcellular response to fibroblast growth factor stimulus
A0045091biological_processregulation of single stranded viral RNA replication via double stranded DNA intermediate
A0045236molecular_functionCXCR chemokine receptor binding
A0045744biological_processnegative regulation of G protein-coupled receptor signaling pathway
A0045766biological_processpositive regulation of angiogenesis
A0048566biological_processembryonic digestive tract development
A0050930biological_processinduction of positive chemotaxis
A0060354biological_processnegative regulation of cell adhesion molecule production
A0061844biological_processantimicrobial humoral immune response mediated by antimicrobial peptide
A0070098biological_processchemokine-mediated signaling pathway
A0071222biological_processcellular response to lipopolysaccharide
A0071347biological_processcellular response to interleukin-1
A0071356biological_processcellular response to tumor necrosis factor
A0090023biological_processpositive regulation of neutrophil chemotaxis
A2000535biological_processregulation of entry of bacterium into host cell
B0001525biological_processangiogenesis
B0002237biological_processresponse to molecule of bacterial origin
B0005125molecular_functioncytokine activity
B0005153molecular_functioninterleukin-8 receptor binding
B0005515molecular_functionprotein binding
B0005576cellular_componentextracellular region
B0005615cellular_componentextracellular space
B0006935biological_processchemotaxis
B0006952biological_processdefense response
B0006954biological_processinflammatory response
B0006955biological_processimmune response
B0007165biological_processsignal transduction
B0007186biological_processG protein-coupled receptor signaling pathway
B0008009molecular_functionchemokine activity
B0008201molecular_functionheparin binding
B0008285biological_processnegative regulation of cell population proliferation
B0010628biological_processpositive regulation of gene expression
B0010629biological_processnegative regulation of gene expression
B0019722biological_processcalcium-mediated signaling
B0030155biological_processregulation of cell adhesion
B0030593biological_processneutrophil chemotaxis
B0031328biological_processpositive regulation of cellular biosynthetic process
B0031623biological_processreceptor internalization
B0034976biological_processresponse to endoplasmic reticulum stress
B0035556biological_processintracellular signal transduction
B0042119biological_processneutrophil activation
B0044344biological_processcellular response to fibroblast growth factor stimulus
B0045091biological_processregulation of single stranded viral RNA replication via double stranded DNA intermediate
B0045236molecular_functionCXCR chemokine receptor binding
B0045744biological_processnegative regulation of G protein-coupled receptor signaling pathway
B0045766biological_processpositive regulation of angiogenesis
B0048566biological_processembryonic digestive tract development
B0050930biological_processinduction of positive chemotaxis
B0060354biological_processnegative regulation of cell adhesion molecule production
B0061844biological_processantimicrobial humoral immune response mediated by antimicrobial peptide
B0070098biological_processchemokine-mediated signaling pathway
B0071222biological_processcellular response to lipopolysaccharide
B0071347biological_processcellular response to interleukin-1
B0071356biological_processcellular response to tumor necrosis factor
B0090023biological_processpositive regulation of neutrophil chemotaxis
B2000535biological_processregulation of entry of bacterium into host cell
C0001525biological_processangiogenesis
C0002237biological_processresponse to molecule of bacterial origin
C0005125molecular_functioncytokine activity
C0005153molecular_functioninterleukin-8 receptor binding
C0005515molecular_functionprotein binding
C0005576cellular_componentextracellular region
C0005615cellular_componentextracellular space
C0006935biological_processchemotaxis
C0006952biological_processdefense response
C0006954biological_processinflammatory response
C0006955biological_processimmune response
C0007165biological_processsignal transduction
C0007186biological_processG protein-coupled receptor signaling pathway
C0008009molecular_functionchemokine activity
C0008201molecular_functionheparin binding
C0008285biological_processnegative regulation of cell population proliferation
C0010628biological_processpositive regulation of gene expression
C0010629biological_processnegative regulation of gene expression
C0019722biological_processcalcium-mediated signaling
C0030155biological_processregulation of cell adhesion
C0030593biological_processneutrophil chemotaxis
C0031328biological_processpositive regulation of cellular biosynthetic process
C0031623biological_processreceptor internalization
C0034976biological_processresponse to endoplasmic reticulum stress
C0035556biological_processintracellular signal transduction
C0042119biological_processneutrophil activation
C0044344biological_processcellular response to fibroblast growth factor stimulus
C0045091biological_processregulation of single stranded viral RNA replication via double stranded DNA intermediate
C0045236molecular_functionCXCR chemokine receptor binding
C0045744biological_processnegative regulation of G protein-coupled receptor signaling pathway
C0045766biological_processpositive regulation of angiogenesis
C0048566biological_processembryonic digestive tract development
C0050930biological_processinduction of positive chemotaxis
C0060354biological_processnegative regulation of cell adhesion molecule production
C0061844biological_processantimicrobial humoral immune response mediated by antimicrobial peptide
C0070098biological_processchemokine-mediated signaling pathway
C0071222biological_processcellular response to lipopolysaccharide
C0071347biological_processcellular response to interleukin-1
C0071356biological_processcellular response to tumor necrosis factor
C0090023biological_processpositive regulation of neutrophil chemotaxis
C2000535biological_processregulation of entry of bacterium into host cell
D0001525biological_processangiogenesis
D0002237biological_processresponse to molecule of bacterial origin
D0005125molecular_functioncytokine activity
D0005153molecular_functioninterleukin-8 receptor binding
D0005515molecular_functionprotein binding
D0005576cellular_componentextracellular region
D0005615cellular_componentextracellular space
D0006935biological_processchemotaxis
D0006952biological_processdefense response
D0006954biological_processinflammatory response
D0006955biological_processimmune response
D0007165biological_processsignal transduction
D0007186biological_processG protein-coupled receptor signaling pathway
D0008009molecular_functionchemokine activity
D0008201molecular_functionheparin binding
D0008285biological_processnegative regulation of cell population proliferation
D0010628biological_processpositive regulation of gene expression
D0010629biological_processnegative regulation of gene expression
D0019722biological_processcalcium-mediated signaling
D0030155biological_processregulation of cell adhesion
D0030593biological_processneutrophil chemotaxis
D0031328biological_processpositive regulation of cellular biosynthetic process
D0031623biological_processreceptor internalization
D0034976biological_processresponse to endoplasmic reticulum stress
D0035556biological_processintracellular signal transduction
D0042119biological_processneutrophil activation
D0044344biological_processcellular response to fibroblast growth factor stimulus
D0045091biological_processregulation of single stranded viral RNA replication via double stranded DNA intermediate
D0045236molecular_functionCXCR chemokine receptor binding
D0045744biological_processnegative regulation of G protein-coupled receptor signaling pathway
D0045766biological_processpositive regulation of angiogenesis
D0048566biological_processembryonic digestive tract development
D0050930biological_processinduction of positive chemotaxis
D0060354biological_processnegative regulation of cell adhesion molecule production
D0061844biological_processantimicrobial humoral immune response mediated by antimicrobial peptide
D0070098biological_processchemokine-mediated signaling pathway
D0071222biological_processcellular response to lipopolysaccharide
D0071347biological_processcellular response to interleukin-1
D0071356biological_processcellular response to tumor necrosis factor
D0090023biological_processpositive regulation of neutrophil chemotaxis
D2000535biological_processregulation of entry of bacterium into host cell
Functional Information from PDB Data
site_idAC1
Number of Residues6
DetailsBINDING SITE FOR RESIDUE SO4 D 101
ChainResidue
CPRO16
CPHE17
CHOH136
DSER1
DARG6
DHOH224

site_idAC2
Number of Residues7
DetailsBINDING SITE FOR RESIDUE SO4 B 134
ChainResidue
BCYS5
BASN56
BARG60
BHOH169
BALA2
BLYS3
BGLU4

site_idAC3
Number of Residues4
DetailsBINDING SITE FOR RESIDUE SO4 D 190
ChainResidue
DHIS18
DPRO19
DLYS20
DHOH282

Functional Information from PROSITE/UniProt
site_idPS00471
Number of Residues46
DetailsSMALL_CYTOKINES_CXC Small cytokines (intercrine/chemokine) C-x-C subfamily signature. CqCIktyskpFhpKfIkeLrviesGpcCantEIIvklsdgrel.CLD
ChainResidueDetails
ACYS7-ASP52

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues4
DetailsSITE: Cleavage; by MMP9
ChainResidueDetails
ASER1
BSER1
CSER1
DSER1

218853

PDB entries from 2024-04-24

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