1QAS
1-PHOSPHATIDYLINOSITOL-4,5-BISPHOSPHATE PHOSPHODIESTERASE DELTA 1
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004435 | molecular_function | phosphatidylinositol phospholipase C activity |
| A | 0005509 | molecular_function | calcium ion binding |
| A | 0006629 | biological_process | lipid metabolic process |
| A | 0007165 | biological_process | signal transduction |
| A | 0008081 | molecular_function | phosphoric diester hydrolase activity |
| A | 0035556 | biological_process | intracellular signal transduction |
| B | 0004435 | molecular_function | phosphatidylinositol phospholipase C activity |
| B | 0005509 | molecular_function | calcium ion binding |
| B | 0006629 | biological_process | lipid metabolic process |
| B | 0007165 | biological_process | signal transduction |
| B | 0008081 | molecular_function | phosphoric diester hydrolase activity |
| B | 0035556 | biological_process | intracellular signal transduction |
Functional Information from PROSITE/UniProt
| site_id | PS00018 |
| Number of Residues | 13 |
| Details | EF_HAND_1 EF-hand calcium-binding domain. DKNKDNKMNfkEL |
| Chain | Residue | Details |
| A | ASP153-LEU165 | |
| A | ASP189-ILE201 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 4 |
| Details | ACT_SITE: |
| Chain | Residue | Details |
| B | HIS311 | |
| B | HIS356 | |
| A | HIS311 | |
| A | HIS356 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 20 |
| Details | BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00448 |
| Chain | Residue | Details |
| A | ASP157 | |
| A | LYS159 | |
| A | GLU164 | |
| A | ASP153 | |
| A | ASN155 | |
| B | ASP153 | |
| B | ASN155 | |
| B | ASP157 | |
| B | LYS159 | |
| B | GLU164 | |
| B | ASP189 | |
| B | SER191 | |
| B | THR193 | |
| B | SER195 | |
| B | GLU200 | |
| A | ASP189 | |
| A | SER191 | |
| A | THR193 | |
| A | SER195 | |
| A | GLU200 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 28 |
| Details | BINDING: |
| Chain | Residue | Details |
| A | ASN677 | |
| A | ASP706 | |
| A | TYR707 | |
| A | ASP708 | |
| B | ASN312 | |
| B | GLU341 | |
| B | ASP343 | |
| B | GLU390 | |
| B | LYS438 | |
| B | LYS440 | |
| B | SER522 | |
| B | ARG549 | |
| B | ILE651 | |
| B | ASP653 | |
| B | ASN677 | |
| B | ASP706 | |
| B | TYR707 | |
| B | ASP708 | |
| A | ASN312 | |
| A | GLU341 | |
| A | ASP343 | |
| A | GLU390 | |
| A | LYS438 | |
| A | LYS440 | |
| A | SER522 | |
| A | ARG549 | |
| A | ILE651 | |
| A | ASP653 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphothreonine => ECO:0000250|UniProtKB:Q8R3B1 |
| Chain | Residue | Details |
| A | THR457 | |
| B | THR457 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:P51178 |
| Chain | Residue | Details |
| A | SER460 | |
| B | SER460 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 2 |
| Details | CARBOHYD: O-linked (GlcNAc) serine => ECO:0000269|PubMed:24098488 |
| Chain | Residue | Details |
| A | SER191 | |
| B | SER191 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 2 |
| Details | CARBOHYD: O-linked (GlcNAc) threonine => ECO:0000269|PubMed:24098488 |
| Chain | Residue | Details |
| A | THR193 | |
| B | THR193 |
Catalytic Information from CSA
| site_id | MCSA1 |
| Number of Residues | 6 |
| Details | M-CSA 28 |
| Chain | Residue | Details |
| A | HIS311 | electrostatic stabiliser, hydrogen bond donor |
| A | ASN312 | metal ligand |
| A | GLU341 | electrostatic stabiliser, hydrogen bond acceptor, increase acidity, metal ligand |
| A | ASP343 | metal ligand |
| A | HIS356 | hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor |
| A | GLU390 | hydrogen bond acceptor, hydrogen bond donor, increase acidity, metal ligand, proton acceptor, proton donor |
| site_id | MCSA2 |
| Number of Residues | 6 |
| Details | M-CSA 28 |
| Chain | Residue | Details |
| B | HIS311 | electrostatic stabiliser, hydrogen bond donor |
| B | ASN312 | metal ligand |
| B | GLU341 | electrostatic stabiliser, hydrogen bond acceptor, increase acidity, metal ligand |
| B | ASP343 | metal ligand |
| B | HIS356 | hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor |
| B | GLU390 | hydrogen bond acceptor, hydrogen bond donor, increase acidity, metal ligand, proton acceptor, proton donor |
