1Q8K

Solution structure of alpha subunit of human eIF2

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000423	biological_process	mitophagy
A	0003676	molecular_function	nucleic acid binding
A	0003723	molecular_function	RNA binding
A	0003743	molecular_function	translation initiation factor activity
A	0005515	molecular_function	protein binding
A	0005634	cellular_component	nucleus
A	0005737	cellular_component	cytoplasm
A	0005739	cellular_component	mitochondrion
A	0005829	cellular_component	cytosol
A	0005850	cellular_component	eukaryotic translation initiation factor 2 complex
A	0006412	biological_process	translation
A	0006413	biological_process	translational initiation
A	0006417	biological_process	regulation of translation
A	0010494	cellular_component	cytoplasmic stress granule
A	0016020	cellular_component	membrane
A	0032057	biological_process	negative regulation of translational initiation in response to stress
A	0033290	cellular_component	eukaryotic 48S preinitiation complex
A	0034063	biological_process	stress granule assembly
A	0034198	biological_process	cellular response to amino acid starvation
A	0034599	biological_process	cellular response to oxidative stress
A	0034605	biological_process	cellular response to heat
A	0034644	biological_process	cellular response to UV
A	0034976	biological_process	response to endoplasmic reticulum stress
A	0036490	biological_process	regulation of translation in response to endoplasmic reticulum stress
A	0036499	biological_process	PERK-mediated unfolded protein response
A	0043022	molecular_function	ribosome binding
A	0043558	biological_process	regulation of translational initiation in response to stress
A	0044207	cellular_component	translation initiation ternary complex
A	0045202	cellular_component	synapse
A	0070062	cellular_component	extracellular exosome
A	0097250	biological_process	mitochondrial respirasome assembly
A	0097451	cellular_component	glial limiting end-foot
A	0140468	biological_process	HRI-mediated signaling
A	1904373	biological_process	response to kainic acid
A	1990737	biological_process	response to manganese-induced endoplasmic reticulum stress
A	2000676	biological_process	positive regulation of type B pancreatic cell apoptotic process

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	71
Details	Domain: {"description":"S1 motif","evidences":[{"source":"PROSITE-ProRule","id":"PRU00180","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	1
Details	Modified residue: {"description":"Phosphoserine; by HRI","evidences":[{"source":"UniProtKB","id":"P83268","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	1
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"38340717","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19690332","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"24275569","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	1
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"19608861","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	1
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	2
Details	Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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