1Q8H
Crystal structure of porcine osteocalcin
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0001649 | biological_process | osteoblast differentiation |
| A | 0001956 | biological_process | positive regulation of neurotransmitter secretion |
| A | 0005179 | molecular_function | hormone activity |
| A | 0005509 | molecular_function | calcium ion binding |
| A | 0005576 | cellular_component | extracellular region |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0007165 | biological_process | signal transduction |
| A | 0007420 | biological_process | brain development |
| A | 0007611 | biological_process | learning or memory |
| A | 0008147 | molecular_function | structural constituent of bone |
| A | 0030500 | biological_process | regulation of bone mineralization |
| A | 0031214 | biological_process | biomineral tissue development |
| A | 0032571 | biological_process | response to vitamin K |
| A | 0032869 | biological_process | cellular response to insulin stimulus |
| A | 0042593 | biological_process | glucose homeostasis |
| A | 0044342 | biological_process | type B pancreatic cell proliferation |
| A | 0046848 | molecular_function | hydroxyapatite binding |
| A | 0046872 | molecular_function | metal ion binding |
| A | 0050890 | biological_process | cognition |
| A | 0060348 | biological_process | bone development |
| A | 1900076 | biological_process | regulation of cellular response to insulin stimulus |
| A | 1903011 | biological_process | negative regulation of bone development |
| A | 2000224 | biological_process | regulation of testosterone biosynthetic process |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE CA A 71 |
| Chain | Residue |
| A | CGU17 |
| A | CGU21 |
| A | CGU24 |
| A | HOH87 |
| site_id | AC2 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE CA A 72 |
| Chain | Residue |
| A | HOH118 |
| A | CGU17 |
| A | CGU24 |
| A | ASP30 |
| A | HOH88 |
| A | HOH97 |
| site_id | AC3 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE CA A 73 |
| Chain | Residue |
| A | CGU21 |
| A | CGU21 |
| A | CGU24 |
| A | CGU24 |
| A | HOH93 |
| A | HOH93 |
Functional Information from PROSITE/UniProt
| site_id | PS00011 |
| Number of Residues | 26 |
| Details | GLA_1 Vitamin K-dependent carboxylation domain. EprREvCelnpdcDeladhigfqe.AY |
| Chain | Residue | Details |
| A | CGU17-TYR42 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 4 |
| Details | BINDING: BINDING => ECO:0000250|UniProtKB:P02820 |
| Chain | Residue | Details |
| A | CGU17 | |
| A | CGU21 | |
| A | CGU24 | |
| A | ASP30 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 1 |
| Details | MOD_RES: Hydroxyproline => ECO:0000269|PubMed:6332627 |
| Chain | Residue | Details |
| A | PRO9 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 3 |
| Details | MOD_RES: 4-carboxyglutamate => ECO:0000255|PROSITE-ProRule:PRU00463, ECO:0000269|PubMed:14586470, ECO:0000269|PubMed:6332627 |
| Chain | Residue | Details |
| A | CGU17 | |
| A | CGU21 | |
| A | CGU24 |
