1Q7L

Zn-binding domain of the T347G mutant of human aminoacylase-I

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004046	molecular_function	aminoacylase activity
A	0005737	cellular_component	cytoplasm
A	0006520	biological_process	amino acid metabolic process
A	0016787	molecular_function	hydrolase activity
B	0016787	molecular_function	hydrolase activity
C	0004046	molecular_function	aminoacylase activity
C	0005737	cellular_component	cytoplasm
C	0006520	biological_process	amino acid metabolic process
C	0016787	molecular_function	hydrolase activity
D	0016787	molecular_function	hydrolase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	8
Details	BINDING SITE FOR RESIDUE ZN A 1002

Chain	Residue
A	HIS80
A	ASP113
A	GLU147
A	GLU148
A	GLU175
A	ZN1001
C	HOH701
C	GLY901

---

site_id	AC2
Number of Residues	7
Details	BINDING SITE FOR RESIDUE ZN A 1001

Chain	Residue
A	GLU148
A	ZN1002
B	HIS373
C	HOH701
C	HOH703
C	GLY901
A	ASP113

---

site_id	AC3
Number of Residues	8
Details	BINDING SITE FOR RESIDUE ZN C 1012

Chain	Residue
C	HIS80
C	ASP113
C	GLU147
C	GLU148
C	GLU175
C	HOH702
C	GLY902
C	ZN1011

---

site_id	AC4
Number of Residues	7
Details	BINDING SITE FOR RESIDUE ZN C 1011

Chain	Residue
C	ASP113
C	GLU148
C	HOH702
C	HOH704
C	GLY902
C	ZN1012
D	HIS373

---

site_id	AC5
Number of Residues	12
Details	BINDING SITE FOR RESIDUE GLY C 901

Chain	Residue
A	HIS80
A	ASP113
A	GLU147
A	GLU148
A	GLU175
A	ZN1001
A	ZN1002
B	HIS373
C	HOH701
C	HOH703
C	HOH1230
C	HOH1564

---

site_id	AC6
Number of Residues	11
Details	BINDING SITE FOR RESIDUE GLY C 902

Chain	Residue
C	HIS80
C	ASP113
C	GLU147
C	GLU148
C	GLU175
C	HOH702
C	HOH704
C	ZN1011
C	ZN1012
C	HOH1318
D	HIS373

---

Functional Information from PROSITE/UniProt

site_id	PS00758
Number of Residues	10
Details	ARGE_DAPE_CPG2_1 ArgE / dapE / ACY1 / CPG2 / yscS family signature 1. ILLNSHtDVV

Chain	Residue	Details
A	ILE75-VAL84

---

site_id	PS00759
Number of Residues	40
Details	ARGE_DAPE_CPG2_2 ArgE / dapE / ACY1 / CPG2 / yscS family signature 2. AQDmKCvsIqyLeavrrlkveghrfprt.IhMTFvpDEEvG

Chain	Residue	Details
A	ALA111-GLY150

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	BINDING: BINDING => ECO:0000269|PubMed:12933810

Chain	Residue	Details
B	HIS373
D	HIS373

---

site_id	SWS_FT_FI2
Number of Residues	2
Details	ACT_SITE: Proton acceptor => ECO:0000269|PubMed:12933810

Chain	Residue	Details
A	GLU147
C	GLU147

---

site_id	SWS_FT_FI3
Number of Residues	8
Details	BINDING: BINDING => ECO:0000269|PubMed:12933810

Chain	Residue	Details
A	HIS80
A	ASP113
A	GLU148
A	GLU175
C	HIS80
C	ASP113
C	GLU148
C	GLU175

---

Catalytic Information from CSA

site_id	CSA1
Number of Residues	1
Details	Annotated By Reference To The Literature 1amp

Chain	Residue	Details
A	GLU147

---

site_id	CSA2
Number of Residues	1
Details	Annotated By Reference To The Literature 1amp

Chain	Residue	Details
C	GLU147

---