1Q78

Crystal structure of poly(A) polymerase in complex with 3'-dATP and magnesium chloride

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003723	molecular_function	RNA binding
A	0005634	cellular_component	nucleus
A	0016779	molecular_function	nucleotidyltransferase activity
A	0031123	biological_process	RNA 3'-end processing
A	1990817	molecular_function	poly(A) RNA polymerase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	3
Details	BINDING SITE FOR RESIDUE MG A 1002

Chain	Residue
A	ASP113
A	ASP115
A	3AT1000

---

site_id	AC2
Number of Residues	18
Details	BINDING SITE FOR RESIDUE 3AT A 1000

Chain	Residue
A	LYS228
A	TYR237
A	GLY246
A	VAL247
A	THR317
A	MG1002
A	HOH2043
A	HOH2050
A	HOH2060
A	HOH2069
A	HOH2108
A	HOH2117
A	PHE100
A	GLY101
A	SER102
A	ASP115
A	ASN202
A	VAL206

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"PubMed","id":"10944102","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"15328606","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"1F5A","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1Q78","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1Q79","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"10944102","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"1F5A","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	3
Details	Binding site: {"evidences":[{"source":"PubMed","id":"10944102","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15328606","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1F5A","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1Q79","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"10944102","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"15328606","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"1F5A","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1Q79","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	4
Details	Site: {"description":"Interaction with RNA","evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	1
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"P51003","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	2
Details	Modified residue: {"description":"Cysteine sulfinic acid (-SO2H)","evidences":[{"source":"PubMed","id":"15328606","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1Q78","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1Q79","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	1
Details	Modified residue: {"description":"Cysteine sulfenic acid (-SOH)","evidences":[{"source":"PubMed","id":"15328606","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1Q79","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

Catalytic Information from CSA

site_id	CSA1
Number of Residues	1
Details	Annotated By Reference To The Literature 1fa0

Chain	Residue	Details
A	LYS228

---