1Q56
NMR structure of the B0 isoform of the agrin G3 domain in its Ca2+ bound state
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 4 |
| Details | BINDING: BINDING => ECO:0000250|UniProtKB:P25304 |
| Chain | Residue | Details |
| A | SER86 | |
| A | THR103 | |
| A | HIS153 | |
| A | LEU155 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 1 |
| Details | SITE: Critical for cleavage by neurotrypsin => ECO:0000250 |
| Chain | Residue | Details |
| A | GLU8 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 1 |
| Details | SITE: Cleavage, beta site; by neurotrypsin => ECO:0000250 |
| Chain | Residue | Details |
| A | LYS9 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 1 |
| Details | SITE: Alternative splice site to produce 'B' isoforms => ECO:0000250 |
| Chain | Residue | Details |
| A | SER34 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 1 |
| Details | SITE: Highly important for the agrin receptor complex activity of the 'B8' insert => ECO:0000250 |
| Chain | Residue | Details |
| A | LEU38 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 1 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255 |
| Chain | Residue | Details |
| A | LYS154 |
