Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004222 | molecular_function | metalloendopeptidase activity |
| A | 0006508 | biological_process | proteolysis |
| A | 0008237 | molecular_function | metallopeptidase activity |
| A | 0008270 | molecular_function | zinc ion binding |
| A | 0031012 | cellular_component | extracellular matrix |
| B | 0004222 | molecular_function | metalloendopeptidase activity |
| B | 0006508 | biological_process | proteolysis |
| B | 0008237 | molecular_function | metallopeptidase activity |
| B | 0008270 | molecular_function | zinc ion binding |
| B | 0031012 | cellular_component | extracellular matrix |
| C | 0004222 | molecular_function | metalloendopeptidase activity |
| C | 0006508 | biological_process | proteolysis |
| C | 0008237 | molecular_function | metallopeptidase activity |
| C | 0008270 | molecular_function | zinc ion binding |
| C | 0031012 | cellular_component | extracellular matrix |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN A 464 |
| Chain | Residue |
| A | HIS217 |
| A | HIS221 |
| A | HIS227 |
| A | NGH480 |
| site_id | AC2 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN A 465 |
| Chain | Residue |
| A | HIS167 |
| A | ASP169 |
| A | HIS182 |
| A | HIS195 |
| site_id | AC3 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE CA A 466 |
| Chain | Residue |
| A | GLY175 |
| A | GLY177 |
| A | SER179 |
| A | ASP197 |
| A | GLU200 |
| A | ASP174 |
| site_id | AC4 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE CA A 467 |
| Chain | Residue |
| A | ASP157 |
| A | GLY189 |
| A | TYR191 |
| A | ASP193 |
| site_id | AC5 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE CA A 468 |
| Chain | Residue |
| A | ASP123 |
| A | ASP198 |
| A | GLU200 |
| A | HOH564 |
| A | HOH597 |
| site_id | AC6 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN B 469 |
| Chain | Residue |
| B | HIS217 |
| B | HIS221 |
| B | HIS227 |
| B | NGH479 |
| site_id | AC7 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN B 470 |
| Chain | Residue |
| B | HIS167 |
| B | ASP169 |
| B | HIS182 |
| B | HIS195 |
| site_id | AC8 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE CA B 471 |
| Chain | Residue |
| B | ASP174 |
| B | GLY175 |
| B | GLY177 |
| B | SER179 |
| B | ASP197 |
| B | GLU200 |
| site_id | AC9 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE CA B 472 |
| Chain | Residue |
| B | ASP157 |
| B | GLY189 |
| B | TYR191 |
| B | ASP193 |
| B | HOH513 |
| site_id | BC1 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE CA B 473 |
| Chain | Residue |
| B | ASP123 |
| B | ASP198 |
| B | GLU200 |
| B | HOH482 |
| B | HOH500 |
| site_id | BC2 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE ZN C 474 |
| Chain | Residue |
| C | HIS217 |
| C | HIS221 |
| C | HIS227 |
| C | NGH481 |
| C | HOH491 |
| site_id | BC3 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN C 475 |
| Chain | Residue |
| C | HIS167 |
| C | ASP169 |
| C | HIS182 |
| C | HIS195 |
| site_id | BC4 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE CA C 476 |
| Chain | Residue |
| C | ASP174 |
| C | GLY175 |
| C | GLY177 |
| C | SER179 |
| C | ASP197 |
| C | GLU200 |
| site_id | BC5 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE CA C 477 |
| Chain | Residue |
| C | ASP157 |
| C | GLY189 |
| C | TYR191 |
| C | ASP193 |
| C | HOH498 |
| site_id | BC6 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE CA C 478 |
| Chain | Residue |
| C | ASP123 |
| C | ASP198 |
| C | GLU200 |
| site_id | BC7 |
| Number of Residues | 13 |
| Details | BINDING SITE FOR RESIDUE NGH B 479 |
| Chain | Residue |
| B | SER179 |
| B | LEU180 |
| B | ALA181 |
| B | LEU213 |
| B | HIS217 |
| B | GLU218 |
| B | HIS221 |
| B | HIS227 |
| B | PRO237 |
| B | TYR239 |
| B | ZN469 |
| B | HOH583 |
| C | HIS178 |
| site_id | BC8 |
| Number of Residues | 15 |
| Details | BINDING SITE FOR RESIDUE NGH A 480 |
| Chain | Residue |
| A | HIS178 |
| A | SER179 |
| A | LEU180 |
| A | ALA181 |
| A | LEU213 |
| A | HIS217 |
| A | GLU218 |
| A | HIS221 |
| A | HIS227 |
| A | PRO237 |
| A | SER241 |
| A | ZN464 |
| A | HOH485 |
| A | HOH612 |
| B | HIS178 |
| site_id | BC9 |
| Number of Residues | 21 |
| Details | BINDING SITE FOR RESIDUE NGH C 481 |
| Chain | Residue |
| B | PHE242 |
| B | HOH499 |
| B | HOH535 |
| B | HOH605 |
| C | SER179 |
| C | LEU180 |
| C | ALA181 |
| C | HIS217 |
| C | GLU218 |
| C | HIS221 |
| C | HIS227 |
| C | LEU234 |
| C | LEU238 |
| C | TYR239 |
| C | ZN474 |
| C | HOH491 |
| C | HOH504 |
| C | HOH517 |
| C | HOH520 |
| C | HOH544 |
| B | ASN240 |
Functional Information from PROSITE/UniProt
| site_id | PS00142 |
| Number of Residues | 10 |
| Details | ZINC_PROTEASE Neutral zinc metallopeptidases, zinc-binding region signature. VAAHELGHSL |
| Chain | Residue | Details |
| A | VAL214-LEU223 | |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 3 |
| Details | Active site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU10095","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"15095982","evidenceCode":"ECO:0000269"}]} |
| site_id | SWS_FT_FI2 |
| Number of Residues | 21 |
| Details | Binding site: {} |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1hfs |
| Chain | Residue | Details |
| A | GLU218 | |
| A | MET235 | |
| site_id | CSA2 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1hfs |
| Chain | Residue | Details |
| B | GLU218 | |
| B | MET235 | |
| site_id | CSA3 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1hfs |
| Chain | Residue | Details |
| C | GLU218 | |
| C | MET235 | |
| site_id | CSA4 |
| Number of Residues | 1 |
| Details | Annotated By Reference To The Literature 1hfs |
| Chain | Residue | Details |
| A | GLU218 | |
| site_id | CSA5 |
| Number of Residues | 1 |
| Details | Annotated By Reference To The Literature 1hfs |
| Chain | Residue | Details |
| B | GLU218 | |
| site_id | CSA6 |
| Number of Residues | 1 |
| Details | Annotated By Reference To The Literature 1hfs |
| Chain | Residue | Details |
| C | GLU218 | |
