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1Q3A

Crystal structure of the catalytic domain of human matrix metalloproteinase 10

Functional Information from GO Data
ChainGOidnamespacecontents
A0004222molecular_functionmetalloendopeptidase activity
A0006508biological_processproteolysis
A0008237molecular_functionmetallopeptidase activity
A0008270molecular_functionzinc ion binding
A0031012cellular_componentextracellular matrix
B0004222molecular_functionmetalloendopeptidase activity
B0006508biological_processproteolysis
B0008237molecular_functionmetallopeptidase activity
B0008270molecular_functionzinc ion binding
B0031012cellular_componentextracellular matrix
C0004222molecular_functionmetalloendopeptidase activity
C0006508biological_processproteolysis
C0008237molecular_functionmetallopeptidase activity
C0008270molecular_functionzinc ion binding
C0031012cellular_componentextracellular matrix
Functional Information from PDB Data
site_idAC1
Number of Residues4
DetailsBINDING SITE FOR RESIDUE ZN A 464
ChainResidue
AHIS217
AHIS221
AHIS227
ANGH480

site_idAC2
Number of Residues4
DetailsBINDING SITE FOR RESIDUE ZN A 465
ChainResidue
AHIS167
AASP169
AHIS182
AHIS195

site_idAC3
Number of Residues6
DetailsBINDING SITE FOR RESIDUE CA A 466
ChainResidue
AGLY175
AGLY177
ASER179
AASP197
AGLU200
AASP174

site_idAC4
Number of Residues4
DetailsBINDING SITE FOR RESIDUE CA A 467
ChainResidue
AASP157
AGLY189
ATYR191
AASP193

site_idAC5
Number of Residues5
DetailsBINDING SITE FOR RESIDUE CA A 468
ChainResidue
AASP123
AASP198
AGLU200
AHOH564
AHOH597

site_idAC6
Number of Residues4
DetailsBINDING SITE FOR RESIDUE ZN B 469
ChainResidue
BHIS217
BHIS221
BHIS227
BNGH479

site_idAC7
Number of Residues4
DetailsBINDING SITE FOR RESIDUE ZN B 470
ChainResidue
BHIS167
BASP169
BHIS182
BHIS195

site_idAC8
Number of Residues6
DetailsBINDING SITE FOR RESIDUE CA B 471
ChainResidue
BASP174
BGLY175
BGLY177
BSER179
BASP197
BGLU200

site_idAC9
Number of Residues5
DetailsBINDING SITE FOR RESIDUE CA B 472
ChainResidue
BASP157
BGLY189
BTYR191
BASP193
BHOH513

site_idBC1
Number of Residues5
DetailsBINDING SITE FOR RESIDUE CA B 473
ChainResidue
BASP123
BASP198
BGLU200
BHOH482
BHOH500

site_idBC2
Number of Residues5
DetailsBINDING SITE FOR RESIDUE ZN C 474
ChainResidue
CHIS217
CHIS221
CHIS227
CNGH481
CHOH491

site_idBC3
Number of Residues4
DetailsBINDING SITE FOR RESIDUE ZN C 475
ChainResidue
CHIS167
CASP169
CHIS182
CHIS195

site_idBC4
Number of Residues6
DetailsBINDING SITE FOR RESIDUE CA C 476
ChainResidue
CASP174
CGLY175
CGLY177
CSER179
CASP197
CGLU200

site_idBC5
Number of Residues5
DetailsBINDING SITE FOR RESIDUE CA C 477
ChainResidue
CASP157
CGLY189
CTYR191
CASP193
CHOH498

site_idBC6
Number of Residues3
DetailsBINDING SITE FOR RESIDUE CA C 478
ChainResidue
CASP123
CASP198
CGLU200

site_idBC7
Number of Residues13
DetailsBINDING SITE FOR RESIDUE NGH B 479
ChainResidue
BSER179
BLEU180
BALA181
BLEU213
BHIS217
BGLU218
BHIS221
BHIS227
BPRO237
BTYR239
BZN469
BHOH583
CHIS178

site_idBC8
Number of Residues15
DetailsBINDING SITE FOR RESIDUE NGH A 480
ChainResidue
AHIS178
ASER179
ALEU180
AALA181
ALEU213
AHIS217
AGLU218
AHIS221
AHIS227
APRO237
ASER241
AZN464
AHOH485
AHOH612
BHIS178

site_idBC9
Number of Residues21
DetailsBINDING SITE FOR RESIDUE NGH C 481
ChainResidue
BPHE242
BHOH499
BHOH535
BHOH605
CSER179
CLEU180
CALA181
CHIS217
CGLU218
CHIS221
CHIS227
CLEU234
CLEU238
CTYR239
CZN474
CHOH491
CHOH504
CHOH517
CHOH520
CHOH544
BASN240

Functional Information from PROSITE/UniProt
site_idPS00142
Number of Residues10
DetailsZINC_PROTEASE Neutral zinc metallopeptidases, zinc-binding region signature. VAAHELGHSL
ChainResidueDetails
AVAL214-LEU223

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues3
DetailsACT_SITE: ACT_SITE => ECO:0000255|PROSITE-ProRule:PRU10095, ECO:0000269|PubMed:15095982
ChainResidueDetails
AGLU218
BGLU218
CGLU218

site_idSWS_FT_FI2
Number of Residues21
DetailsBINDING:
ChainResidueDetails
AHIS167
AASP169
AHIS182
AHIS195
BHIS221
BHIS227
CHIS167
CASP169
CHIS182
CHIS195
CHIS217
CHIS221
CHIS227
AHIS217
AHIS221
AHIS227
BHIS167
BASP169
BHIS182
BHIS195
BHIS217

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PDB entries from 2024-06-12

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