Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0004222 | molecular_function | metalloendopeptidase activity |
A | 0006508 | biological_process | proteolysis |
A | 0008237 | molecular_function | metallopeptidase activity |
A | 0008270 | molecular_function | zinc ion binding |
A | 0031012 | cellular_component | extracellular matrix |
B | 0004222 | molecular_function | metalloendopeptidase activity |
B | 0006508 | biological_process | proteolysis |
B | 0008237 | molecular_function | metallopeptidase activity |
B | 0008270 | molecular_function | zinc ion binding |
B | 0031012 | cellular_component | extracellular matrix |
C | 0004222 | molecular_function | metalloendopeptidase activity |
C | 0006508 | biological_process | proteolysis |
C | 0008237 | molecular_function | metallopeptidase activity |
C | 0008270 | molecular_function | zinc ion binding |
C | 0031012 | cellular_component | extracellular matrix |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE ZN A 464 |
Chain | Residue |
A | HIS217 |
A | HIS221 |
A | HIS227 |
A | NGH480 |
site_id | AC2 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE ZN A 465 |
Chain | Residue |
A | HIS167 |
A | ASP169 |
A | HIS182 |
A | HIS195 |
site_id | AC3 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE CA A 466 |
Chain | Residue |
A | GLY175 |
A | GLY177 |
A | SER179 |
A | ASP197 |
A | GLU200 |
A | ASP174 |
site_id | AC4 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE CA A 467 |
Chain | Residue |
A | ASP157 |
A | GLY189 |
A | TYR191 |
A | ASP193 |
site_id | AC5 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE CA A 468 |
Chain | Residue |
A | ASP123 |
A | ASP198 |
A | GLU200 |
A | HOH564 |
A | HOH597 |
site_id | AC6 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE ZN B 469 |
Chain | Residue |
B | HIS217 |
B | HIS221 |
B | HIS227 |
B | NGH479 |
site_id | AC7 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE ZN B 470 |
Chain | Residue |
B | HIS167 |
B | ASP169 |
B | HIS182 |
B | HIS195 |
site_id | AC8 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE CA B 471 |
Chain | Residue |
B | ASP174 |
B | GLY175 |
B | GLY177 |
B | SER179 |
B | ASP197 |
B | GLU200 |
site_id | AC9 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE CA B 472 |
Chain | Residue |
B | ASP157 |
B | GLY189 |
B | TYR191 |
B | ASP193 |
B | HOH513 |
site_id | BC1 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE CA B 473 |
Chain | Residue |
B | ASP123 |
B | ASP198 |
B | GLU200 |
B | HOH482 |
B | HOH500 |
site_id | BC2 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE ZN C 474 |
Chain | Residue |
C | HIS217 |
C | HIS221 |
C | HIS227 |
C | NGH481 |
C | HOH491 |
site_id | BC3 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE ZN C 475 |
Chain | Residue |
C | HIS167 |
C | ASP169 |
C | HIS182 |
C | HIS195 |
site_id | BC4 |
Number of Residues | 6 |
Details | BINDING SITE FOR RESIDUE CA C 476 |
Chain | Residue |
C | ASP174 |
C | GLY175 |
C | GLY177 |
C | SER179 |
C | ASP197 |
C | GLU200 |
site_id | BC5 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE CA C 477 |
Chain | Residue |
C | ASP157 |
C | GLY189 |
C | TYR191 |
C | ASP193 |
C | HOH498 |
site_id | BC6 |
Number of Residues | 3 |
Details | BINDING SITE FOR RESIDUE CA C 478 |
Chain | Residue |
C | ASP123 |
C | ASP198 |
C | GLU200 |
site_id | BC7 |
Number of Residues | 13 |
Details | BINDING SITE FOR RESIDUE NGH B 479 |
Chain | Residue |
B | SER179 |
B | LEU180 |
B | ALA181 |
B | LEU213 |
B | HIS217 |
B | GLU218 |
B | HIS221 |
B | HIS227 |
B | PRO237 |
B | TYR239 |
B | ZN469 |
B | HOH583 |
C | HIS178 |
site_id | BC8 |
Number of Residues | 15 |
Details | BINDING SITE FOR RESIDUE NGH A 480 |
Chain | Residue |
A | HIS178 |
A | SER179 |
A | LEU180 |
A | ALA181 |
A | LEU213 |
A | HIS217 |
A | GLU218 |
A | HIS221 |
A | HIS227 |
A | PRO237 |
A | SER241 |
A | ZN464 |
A | HOH485 |
A | HOH612 |
B | HIS178 |
site_id | BC9 |
Number of Residues | 21 |
Details | BINDING SITE FOR RESIDUE NGH C 481 |
Chain | Residue |
B | PHE242 |
B | HOH499 |
B | HOH535 |
B | HOH605 |
C | SER179 |
C | LEU180 |
C | ALA181 |
C | HIS217 |
C | GLU218 |
C | HIS221 |
C | HIS227 |
C | LEU234 |
C | LEU238 |
C | TYR239 |
C | ZN474 |
C | HOH491 |
C | HOH504 |
C | HOH517 |
C | HOH520 |
C | HOH544 |
B | ASN240 |
Functional Information from PROSITE/UniProt
site_id | PS00142 |
Number of Residues | 10 |
Details | ZINC_PROTEASE Neutral zinc metallopeptidases, zinc-binding region signature. VAAHELGHSL |
Chain | Residue | Details |
A | VAL214-LEU223 | |
Functional Information from SwissProt/UniProt
Chain | Residue | Details |
A | GLU218 | |
B | GLU218 | |
C | GLU218 | |
site_id | SWS_FT_FI2 |
Number of Residues | 21 |
Details | BINDING: |
Chain | Residue | Details |
A | HIS167 | |
B | HIS182 | |
B | HIS195 | |
B | HIS217 | |
B | HIS221 | |
B | HIS227 | |
C | HIS167 | |
C | ASP169 | |
C | HIS182 | |
C | HIS195 | |
C | HIS217 | |
A | ASP169 | |
C | HIS221 | |
C | HIS227 | |
A | HIS182 | |
A | HIS195 | |
A | HIS217 | |
A | HIS221 | |
A | HIS227 | |
B | HIS167 | |
B | ASP169 | |
Catalytic Information from CSA
site_id | CSA1 |
Number of Residues | 2 |
Details | Annotated By Reference To The Literature 1hfs |
Chain | Residue | Details |
A | GLU218 | |
A | MET235 | |
site_id | CSA2 |
Number of Residues | 2 |
Details | Annotated By Reference To The Literature 1hfs |
Chain | Residue | Details |
B | GLU218 | |
B | MET235 | |
site_id | CSA3 |
Number of Residues | 2 |
Details | Annotated By Reference To The Literature 1hfs |
Chain | Residue | Details |
C | GLU218 | |
C | MET235 | |
site_id | CSA4 |
Number of Residues | 1 |
Details | Annotated By Reference To The Literature 1hfs |
Chain | Residue | Details |
A | GLU218 | |
site_id | CSA5 |
Number of Residues | 1 |
Details | Annotated By Reference To The Literature 1hfs |
Chain | Residue | Details |
B | GLU218 | |
site_id | CSA6 |
Number of Residues | 1 |
Details | Annotated By Reference To The Literature 1hfs |
Chain | Residue | Details |
C | GLU218 | |