1Q32

Crystal Structure Analysis of the Yeast Tyrosyl-DNA Phosphodiesterase

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003690	molecular_function	double-stranded DNA binding
A	0003697	molecular_function	single-stranded DNA binding
A	0004518	molecular_function	nuclease activity
A	0004527	molecular_function	exonuclease activity
A	0005515	molecular_function	protein binding
A	0005634	cellular_component	nucleus
A	0005739	cellular_component	mitochondrion
A	0006281	biological_process	DNA repair
A	0006974	biological_process	DNA damage response
A	0008081	molecular_function	phosphoric diester hydrolase activity
A	0016787	molecular_function	hydrolase activity
A	0017005	molecular_function	3'-tyrosyl-DNA phosphodiesterase activity
A	0070260	molecular_function	5'-tyrosyl-DNA phosphodiesterase activity
B	0003690	molecular_function	double-stranded DNA binding
B	0003697	molecular_function	single-stranded DNA binding
B	0004518	molecular_function	nuclease activity
B	0004527	molecular_function	exonuclease activity
B	0005515	molecular_function	protein binding
B	0005634	cellular_component	nucleus
B	0005739	cellular_component	mitochondrion
B	0006281	biological_process	DNA repair
B	0006974	biological_process	DNA damage response
B	0008081	molecular_function	phosphoric diester hydrolase activity
B	0016787	molecular_function	hydrolase activity
B	0017005	molecular_function	3'-tyrosyl-DNA phosphodiesterase activity
B	0070260	molecular_function	5'-tyrosyl-DNA phosphodiesterase activity
C	0003690	molecular_function	double-stranded DNA binding
C	0003697	molecular_function	single-stranded DNA binding
C	0004518	molecular_function	nuclease activity
C	0004527	molecular_function	exonuclease activity
C	0005515	molecular_function	protein binding
C	0005634	cellular_component	nucleus
C	0005739	cellular_component	mitochondrion
C	0006281	biological_process	DNA repair
C	0006974	biological_process	DNA damage response
C	0008081	molecular_function	phosphoric diester hydrolase activity
C	0016787	molecular_function	hydrolase activity
C	0017005	molecular_function	3'-tyrosyl-DNA phosphodiesterase activity
C	0070260	molecular_function	5'-tyrosyl-DNA phosphodiesterase activity
D	0003690	molecular_function	double-stranded DNA binding
D	0003697	molecular_function	single-stranded DNA binding
D	0004518	molecular_function	nuclease activity
D	0004527	molecular_function	exonuclease activity
D	0005515	molecular_function	protein binding
D	0005634	cellular_component	nucleus
D	0005739	cellular_component	mitochondrion
D	0006281	biological_process	DNA repair
D	0006974	biological_process	DNA damage response
D	0008081	molecular_function	phosphoric diester hydrolase activity
D	0016787	molecular_function	hydrolase activity
D	0017005	molecular_function	3'-tyrosyl-DNA phosphodiesterase activity
D	0070260	molecular_function	5'-tyrosyl-DNA phosphodiesterase activity

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	16
Details	Region: {"description":"Interaction with DNA","evidences":[{"source":"UniProtKB","id":"Q9NUW8","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	4
Details	Active site: {"description":"Nucleophile","evidences":[{"source":"PubMed","id":"16751265","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	4
Details	Active site: {"description":"Proton donor/acceptor","evidences":[{"source":"PubMed","id":"17707402","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	8
Details	Binding site: {"evidences":[{"source":"UniProtKB","id":"Q9NUW8","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	4
Details	Site: {"description":"Interaction with DNA","evidences":[{"source":"UniProtKB","id":"Q9NUW8","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---