1Q32

Crystal Structure Analysis of the Yeast Tyrosyl-DNA Phosphodiesterase

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003690	molecular_function	double-stranded DNA binding
A	0003697	molecular_function	single-stranded DNA binding
A	0004527	molecular_function	exonuclease activity
A	0005634	cellular_component	nucleus
A	0005739	cellular_component	mitochondrion
A	0006281	biological_process	DNA repair
A	0008081	molecular_function	phosphoric diester hydrolase activity
A	0017005	molecular_function	3'-tyrosyl-DNA phosphodiesterase activity
A	0070260	molecular_function	5'-tyrosyl-DNA phosphodiesterase activity
B	0003690	molecular_function	double-stranded DNA binding
B	0003697	molecular_function	single-stranded DNA binding
B	0004527	molecular_function	exonuclease activity
B	0005634	cellular_component	nucleus
B	0005739	cellular_component	mitochondrion
B	0006281	biological_process	DNA repair
B	0008081	molecular_function	phosphoric diester hydrolase activity
B	0017005	molecular_function	3'-tyrosyl-DNA phosphodiesterase activity
B	0070260	molecular_function	5'-tyrosyl-DNA phosphodiesterase activity
C	0003690	molecular_function	double-stranded DNA binding
C	0003697	molecular_function	single-stranded DNA binding
C	0004527	molecular_function	exonuclease activity
C	0005634	cellular_component	nucleus
C	0005739	cellular_component	mitochondrion
C	0006281	biological_process	DNA repair
C	0008081	molecular_function	phosphoric diester hydrolase activity
C	0017005	molecular_function	3'-tyrosyl-DNA phosphodiesterase activity
C	0070260	molecular_function	5'-tyrosyl-DNA phosphodiesterase activity
D	0003690	molecular_function	double-stranded DNA binding
D	0003697	molecular_function	single-stranded DNA binding
D	0004527	molecular_function	exonuclease activity
D	0005634	cellular_component	nucleus
D	0005739	cellular_component	mitochondrion
D	0006281	biological_process	DNA repair
D	0008081	molecular_function	phosphoric diester hydrolase activity
D	0017005	molecular_function	3'-tyrosyl-DNA phosphodiesterase activity
D	0070260	molecular_function	5'-tyrosyl-DNA phosphodiesterase activity

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	ACT_SITE: Nucleophile => ECO:0000269|PubMed:16751265

Chain	Residue	Details
A	HIS182
B	HIS182
C	HIS182
D	HIS182

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site_id	SWS_FT_FI2
Number of Residues	4
Details	ACT_SITE: Proton donor/acceptor => ECO:0000269|PubMed:17707402

Chain	Residue	Details
A	HIS432
B	HIS432
C	HIS432
D	HIS432

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site_id	SWS_FT_FI3
Number of Residues	8
Details	BINDING: BINDING => ECO:0000250|UniProtKB:Q9NUW8

Chain	Residue	Details
A	LYS184
A	LYS434
B	LYS184
B	LYS434
C	LYS184
C	LYS434
D	LYS184
D	LYS434

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site_id	SWS_FT_FI4
Number of Residues	4
Details	SITE: Interaction with DNA => ECO:0000250|UniProtKB:Q9NUW8

Chain	Residue	Details
A	SER467
B	SER467
C	SER467
D	SER467

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