1PZ8
Modulation of agrin function by alternative splicing and Ca2+ binding
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE CA A 701 |
| Chain | Residue |
| A | ASP73 |
| A | LEU90 |
| A | GLN140 |
| A | ASP142 |
| site_id | AC2 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE CA B 702 |
| Chain | Residue |
| B | ASP73 |
| B | LEU90 |
| B | GLN140 |
| B | ASP142 |
| site_id | AC3 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE CA C 703 |
| Chain | Residue |
| C | LEU90 |
| C | GLN140 |
| C | ASP142 |
| C | ASP73 |
| site_id | AC4 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE CA D 704 |
| Chain | Residue |
| D | ASP73 |
| D | LEU90 |
| D | GLN140 |
| D | ASP142 |
| D | HOH764 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 4 |
| Details | BINDING: BINDING => ECO:0000250|UniProtKB:P25304 |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 4 |
| Details | SITE: Alternative splice site to produce 'A' isoform => ECO:0000250 |
| Chain | Residue | Details |
| A | ALA14 | |
| B | ALA14 | |
| C | ALA14 | |
| D | ALA14 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 4 |
| Details | SITE: Cleavage; by MMP1 |
| Chain | Residue | Details |
| A | GLU70 | |
| B | GLU70 | |
| C | GLU70 | |
| D | GLU70 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 4 |
| Details | SITE: Cleavage; by MMP7 |
| Chain | Residue | Details |
| A | ILE79 | |
| B | ILE79 | |
| C | ILE79 | |
| D | ILE79 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 4 |
| Details | SITE: Critical for cleavage by neurotrypsin => ECO:0000250 |
| Chain | Residue | Details |
| A | VAL124 | |
| B | VAL124 | |
| C | VAL124 | |
| D | VAL124 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 4 |
| Details | SITE: Cleavage, beta site; by neurotrypsin => ECO:0000250 |
| Chain | Residue | Details |
| A | GLY125 | |
| B | GLY125 | |
| C | GLY125 | |
| D | GLY125 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 4 |
| Details | SITE: Alternative splice site to produce 'B' isoforms => ECO:0000250 |
| Chain | Residue | Details |
| A | GLY150 | |
| B | GLY150 | |
| C | GLY150 | |
| D | GLY150 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 4 |
| Details | SITE: Highly important for the agrin receptor complex activity of the 'B8' insert => ECO:0000250 |
| Chain | Residue | Details |
| A | ARG154 | |
| B | ARG154 | |
| C | ARG154 | |
| D | ARG154 |
