1PX7

A folding mutant of human class pi glutathione transferase, created by mutating aspartate 153 of the wild-type protein to glutamate

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000122	biological_process	negative regulation of transcription by RNA polymerase II
A	0000302	biological_process	response to reactive oxygen species
A	0002674	biological_process	negative regulation of acute inflammatory response
A	0004364	molecular_function	glutathione transferase activity
A	0004602	molecular_function	glutathione peroxidase activity
A	0005504	molecular_function	fatty acid binding
A	0005515	molecular_function	protein binding
A	0005576	cellular_component	extracellular region
A	0005615	cellular_component	extracellular space
A	0005634	cellular_component	nucleus
A	0005737	cellular_component	cytoplasm
A	0005739	cellular_component	mitochondrion
A	0005829	cellular_component	cytosol
A	0006629	biological_process	lipid metabolic process
A	0006693	biological_process	prostaglandin metabolic process
A	0006749	biological_process	glutathione metabolic process
A	0006805	biological_process	xenobiotic metabolic process
A	0007417	biological_process	central nervous system development
A	0008432	molecular_function	JUN kinase binding
A	0009636	biological_process	response to toxic substance
A	0010804	biological_process	negative regulation of tumor necrosis factor-mediated signaling pathway
A	0014003	biological_process	oligodendrocyte development
A	0015643	molecular_function	toxic substance binding
A	0016740	molecular_function	transferase activity
A	0019901	molecular_function	protein kinase binding
A	0030291	molecular_function	protein serine/threonine kinase inhibitor activity
A	0031100	biological_process	animal organ regeneration
A	0031667	biological_process	response to nutrient levels
A	0031982	cellular_component	vesicle
A	0032355	biological_process	response to estradiol
A	0032691	biological_process	negative regulation of interleukin-1 beta production
A	0032720	biological_process	negative regulation of tumor necrosis factor production
A	0032869	biological_process	cellular response to insulin stimulus
A	0032872	biological_process	regulation of stress-activated MAPK cascade
A	0032873	biological_process	negative regulation of stress-activated MAPK cascade
A	0032930	biological_process	positive regulation of superoxide anion generation
A	0033591	biological_process	response to L-ascorbic acid
A	0034774	cellular_component	secretory granule lumen
A	0035726	biological_process	common myeloid progenitor cell proliferation
A	0035730	molecular_function	S-nitrosoglutathione binding
A	0035731	molecular_function	dinitrosyl-iron complex binding
A	0035732	biological_process	nitric oxide storage
A	0043066	biological_process	negative regulation of apoptotic process
A	0043124	biological_process	negative regulation of canonical NF-kappaB signal transduction
A	0043200	biological_process	response to amino acid
A	0043409	biological_process	negative regulation of MAPK cascade
A	0043651	biological_process	linoleic acid metabolic process
A	0045471	biological_process	response to ethanol
A	0046329	biological_process	negative regulation of JNK cascade
A	0048147	biological_process	negative regulation of fibroblast proliferation
A	0051122	biological_process	hepoxilin biosynthetic process
A	0070026	molecular_function	nitric oxide binding
A	0070062	cellular_component	extracellular exosome
A	0070372	biological_process	regulation of ERK1 and ERK2 cascade
A	0070373	biological_process	negative regulation of ERK1 and ERK2 cascade
A	0070664	biological_process	negative regulation of leukocyte proliferation
A	0071222	biological_process	cellular response to lipopolysaccharide
A	0071364	biological_process	cellular response to epidermal growth factor stimulus
A	0071385	biological_process	cellular response to glucocorticoid stimulus
A	0071460	biological_process	cellular response to cell-matrix adhesion
A	0071638	biological_process	negative regulation of monocyte chemotactic protein-1 production
A	0071672	biological_process	negative regulation of smooth muscle cell chemotaxis
A	0097057	cellular_component	TRAF2-GSTP1 complex
A	0098869	biological_process	cellular oxidant detoxification
A	0110076	biological_process	negative regulation of ferroptosis
A	1901687	biological_process	glutathione derivative biosynthetic process
A	1904706	biological_process	negative regulation of vascular associated smooth muscle cell proliferation
A	1904813	cellular_component	ficolin-1-rich granule lumen
A	2001237	biological_process	negative regulation of extrinsic apoptotic signaling pathway
B	0000122	biological_process	negative regulation of transcription by RNA polymerase II
B	0000302	biological_process	response to reactive oxygen species
B	0002674	biological_process	negative regulation of acute inflammatory response
B	0004364	molecular_function	glutathione transferase activity
B	0004602	molecular_function	glutathione peroxidase activity
B	0005504	molecular_function	fatty acid binding
B	0005515	molecular_function	protein binding
B	0005576	cellular_component	extracellular region
B	0005615	cellular_component	extracellular space
B	0005634	cellular_component	nucleus
B	0005737	cellular_component	cytoplasm
B	0005739	cellular_component	mitochondrion
B	0005829	cellular_component	cytosol
B	0006629	biological_process	lipid metabolic process
B	0006693	biological_process	prostaglandin metabolic process
B	0006749	biological_process	glutathione metabolic process
B	0006805	biological_process	xenobiotic metabolic process
B	0007417	biological_process	central nervous system development
B	0008432	molecular_function	JUN kinase binding
B	0009636	biological_process	response to toxic substance
B	0010804	biological_process	negative regulation of tumor necrosis factor-mediated signaling pathway
B	0014003	biological_process	oligodendrocyte development
B	0015643	molecular_function	toxic substance binding
B	0016740	molecular_function	transferase activity
B	0019901	molecular_function	protein kinase binding
B	0030291	molecular_function	protein serine/threonine kinase inhibitor activity
B	0031100	biological_process	animal organ regeneration
B	0031667	biological_process	response to nutrient levels
B	0031982	cellular_component	vesicle
B	0032355	biological_process	response to estradiol
B	0032691	biological_process	negative regulation of interleukin-1 beta production
B	0032720	biological_process	negative regulation of tumor necrosis factor production
B	0032869	biological_process	cellular response to insulin stimulus
B	0032872	biological_process	regulation of stress-activated MAPK cascade
B	0032873	biological_process	negative regulation of stress-activated MAPK cascade
B	0032930	biological_process	positive regulation of superoxide anion generation
B	0033591	biological_process	response to L-ascorbic acid
B	0034774	cellular_component	secretory granule lumen
B	0035726	biological_process	common myeloid progenitor cell proliferation
B	0035730	molecular_function	S-nitrosoglutathione binding
B	0035731	molecular_function	dinitrosyl-iron complex binding
B	0035732	biological_process	nitric oxide storage
B	0043066	biological_process	negative regulation of apoptotic process
B	0043124	biological_process	negative regulation of canonical NF-kappaB signal transduction
B	0043200	biological_process	response to amino acid
B	0043409	biological_process	negative regulation of MAPK cascade
B	0043651	biological_process	linoleic acid metabolic process
B	0045471	biological_process	response to ethanol
B	0046329	biological_process	negative regulation of JNK cascade
B	0048147	biological_process	negative regulation of fibroblast proliferation
B	0051122	biological_process	hepoxilin biosynthetic process
B	0070026	molecular_function	nitric oxide binding
B	0070062	cellular_component	extracellular exosome
B	0070372	biological_process	regulation of ERK1 and ERK2 cascade
B	0070373	biological_process	negative regulation of ERK1 and ERK2 cascade
B	0070664	biological_process	negative regulation of leukocyte proliferation
B	0071222	biological_process	cellular response to lipopolysaccharide
B	0071364	biological_process	cellular response to epidermal growth factor stimulus
B	0071385	biological_process	cellular response to glucocorticoid stimulus
B	0071460	biological_process	cellular response to cell-matrix adhesion
B	0071638	biological_process	negative regulation of monocyte chemotactic protein-1 production
B	0071672	biological_process	negative regulation of smooth muscle cell chemotaxis
B	0097057	cellular_component	TRAF2-GSTP1 complex
B	0098869	biological_process	cellular oxidant detoxification
B	0110076	biological_process	negative regulation of ferroptosis
B	1901687	biological_process	glutathione derivative biosynthetic process
B	1904706	biological_process	negative regulation of vascular associated smooth muscle cell proliferation
B	1904813	cellular_component	ficolin-1-rich granule lumen
B	2001237	biological_process	negative regulation of extrinsic apoptotic signaling pathway

Functional Information from PDB Data

site_id	AC1
Number of Residues	10
Details	BINDING SITE FOR RESIDUE CA B 3001

Chain	Residue
B	LYS81
B	HOH3201
B	LYS81
B	HOH3094
B	HOH3094
B	HOH3144
B	HOH3144
B	HOH3195
B	HOH3195
B	HOH3201

---

site_id	AC2
Number of Residues	5
Details	BINDING SITE FOR RESIDUE MES A 1001

Chain	Residue
A	ALA22
A	TRP28
A	GLU30
A	GLU197
B	ASP171

---

site_id	AC3
Number of Residues	5
Details	BINDING SITE FOR RESIDUE MES B 1002

Chain	Residue
A	HOH2099
A	HOH2165
B	ALA22
B	TRP28
B	GLU197

---

site_id	AC4
Number of Residues	17
Details	BINDING SITE FOR RESIDUE GSH A 2001

Chain	Residue
A	TYR7
A	PHE8
A	ARG13
A	TRP38
A	LYS44
A	GLN51
A	LEU52
A	PRO53
A	GLN64
A	SER65
A	HOH2022
A	HOH2036
A	HOH2050
A	HOH2159
A	HOH2162
A	HOH2170
B	ASP98

---

site_id	AC5
Number of Residues	15
Details	BINDING SITE FOR RESIDUE GSH B 2002

Chain	Residue
A	ASP98
B	TYR7
B	PHE8
B	ARG13
B	TRP38
B	LYS44
B	GLN51
B	LEU52
B	PRO53
B	GLN64
B	SER65
B	HOH3014
B	HOH3018
B	HOH3182
B	HOH3190

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	79
Details	Domain: {"description":"GST N-terminal"}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	242
Details	Domain: {"description":"GST C-terminal"}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	12
Details	Binding site: {"evidences":[{"source":"PubMed","id":"1522586","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19396894","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19808963","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"9012673","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"9245401","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"9351803","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"9398518","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	4
Details	Modified residue: {"description":"Phosphotyrosine; by EGFR","evidences":[{"source":"PubMed","id":"19254954","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	2
Details	Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	4
Details	Modified residue: {"description":"N6-succinyllysine","evidences":[{"source":"UniProtKB","id":"P19157","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	2
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"19608861","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

Catalytic Information from CSA

site_id	CSA1
Number of Residues	1
Details	Annotated By Reference To The Literature 1oe8

Chain	Residue	Details
A	TYR7

---

site_id	CSA2
Number of Residues	1
Details	Annotated By Reference To The Literature 1oe8

Chain	Residue	Details
B	TYR7

---