1PWW
Crystal structure of Anthrax Lethal Factor active site mutant protein complexed with an optimised peptide substrate in the presence of zinc.
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003824 | molecular_function | catalytic activity |
| A | 0004222 | molecular_function | metalloendopeptidase activity |
| A | 0005515 | molecular_function | protein binding |
| A | 0005576 | cellular_component | extracellular region |
| A | 0006508 | biological_process | proteolysis |
| A | 0008233 | molecular_function | peptidase activity |
| A | 0008237 | molecular_function | metallopeptidase activity |
| A | 0008270 | molecular_function | zinc ion binding |
| A | 0016787 | molecular_function | hydrolase activity |
| A | 0035821 | biological_process | modulation of process of another organism |
| A | 0044164 | cellular_component | host cell cytosol |
| A | 0046872 | molecular_function | metal ion binding |
| A | 0090729 | molecular_function | toxin activity |
| B | 0003824 | molecular_function | catalytic activity |
| B | 0004222 | molecular_function | metalloendopeptidase activity |
| B | 0005515 | molecular_function | protein binding |
| B | 0005576 | cellular_component | extracellular region |
| B | 0006508 | biological_process | proteolysis |
| B | 0008233 | molecular_function | peptidase activity |
| B | 0008237 | molecular_function | metallopeptidase activity |
| B | 0008270 | molecular_function | zinc ion binding |
| B | 0016787 | molecular_function | hydrolase activity |
| B | 0035821 | biological_process | modulation of process of another organism |
| B | 0044164 | cellular_component | host cell cytosol |
| B | 0046872 | molecular_function | metal ion binding |
| B | 0090729 | molecular_function | toxin activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE ZN A 9001 |
| Chain | Residue |
| A | HIS686 |
| A | HIS690 |
| A | TYR728 |
| A | GLU735 |
| C | PRO10 |
| site_id | AC2 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE ZN B 9002 |
| Chain | Residue |
| D | TYR9 |
| D | PRO10 |
| B | HIS686 |
| B | HIS690 |
| B | TYR728 |
| B | GLU735 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 424 |
| Details | Domain: {"description":"ATLF-like 1","evidences":[{"source":"PROSITE-ProRule","id":"PRU01339","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 36 |
| Details | Repeat: {"description":"1","evidences":[{"source":"PubMed","id":"11700563","evidenceCode":"ECO:0000303"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 30 |
| Details | Repeat: {"description":"2","evidences":[{"source":"PubMed","id":"11700563","evidenceCode":"ECO:0000303"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 36 |
| Details | Repeat: {"description":"3","evidences":[{"source":"PubMed","id":"11700563","evidenceCode":"ECO:0000303"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 390 |
| Details | Domain: {"description":"ATLF-like 2","evidences":[{"source":"PROSITE-ProRule","id":"PRU01339","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 68 |
| Details | Region: {"description":"IIA","evidences":[{"source":"PubMed","id":"11700563","evidenceCode":"ECO:0000303"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 326 |
| Details | Region: {"description":"IIB","evidences":[{"source":"PubMed","id":"11700563","evidenceCode":"ECO:0000303"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI8 |
| Number of Residues | 448 |
| Details | Region: {"description":"IV","evidences":[{"source":"PubMed","id":"11700563","evidenceCode":"ECO:0000303"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI9 |
| Number of Residues | 2 |
| Details | Active site: {"description":"Proton acceptor","evidences":[{"source":"PROSITE-ProRule","id":"PRU01339","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"19651869","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"9573135","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI10 |
| Number of Residues | 6 |
| Details | Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU01339","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"11700563","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"14718924","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"14718925","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15911756","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"22342144","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"25372673","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"26492514","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"26578066","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1J7N","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1PWP","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1PWQ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1PWU","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1PWW","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1YQY","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4DV8","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4PKQ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4PKR","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4PKS","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4PKT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4PKV","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4PKW","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4WF6","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4XM6","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4XM7","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5D1S","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5D1T","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI11 |
| Number of Residues | 2 |
| Details | Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU01339","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI12 |
| Number of Residues | 17 |
| Details | Repeat: {"description":"5","evidences":[{"source":"PubMed","id":"11700563","evidenceCode":"ECO:0000303"}]} |
| Chain | Residue | Details |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1pwv |
| Chain | Residue | Details |
| A | CYS687 | |
| A | TYR728 |
| site_id | CSA2 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1pwv |
| Chain | Residue | Details |
| B | CYS687 | |
| B | TYR728 |
| site_id | MCSA1 |
| Number of Residues | 5 |
| Details | M-CSA 641 |
| Chain | Residue | Details |
| A | HIS686 | metal ligand |
| A | CYS687 | proton acceptor, proton donor |
| A | HIS690 | metal ligand |
| A | TYR728 | electrostatic stabiliser |
| A | GLU735 | metal ligand |
| site_id | MCSA2 |
| Number of Residues | 5 |
| Details | M-CSA 641 |
| Chain | Residue | Details |
| B | HIS686 | metal ligand |
| B | CYS687 | proton acceptor, proton donor |
| B | HIS690 | metal ligand |
| B | TYR728 | electrostatic stabiliser |
| B | GLU735 | metal ligand |
