1PV6
Crystal structure of lactose permease
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0005351 | molecular_function | carbohydrate:proton symporter activity |
A | 0005515 | molecular_function | protein binding |
A | 0005886 | cellular_component | plasma membrane |
A | 0008643 | biological_process | carbohydrate transport |
A | 0015293 | molecular_function | symporter activity |
A | 0015528 | molecular_function | lactose:proton symporter activity |
A | 0015767 | biological_process | lactose transport |
A | 0016020 | cellular_component | membrane |
A | 0022857 | molecular_function | transmembrane transporter activity |
A | 0030395 | molecular_function | lactose binding |
A | 0034219 | biological_process | carbohydrate transmembrane transport |
A | 0055085 | biological_process | transmembrane transport |
A | 1902600 | biological_process | proton transmembrane transport |
B | 0005351 | molecular_function | carbohydrate:proton symporter activity |
B | 0005515 | molecular_function | protein binding |
B | 0005886 | cellular_component | plasma membrane |
B | 0008643 | biological_process | carbohydrate transport |
B | 0015293 | molecular_function | symporter activity |
B | 0015528 | molecular_function | lactose:proton symporter activity |
B | 0015767 | biological_process | lactose transport |
B | 0016020 | cellular_component | membrane |
B | 0022857 | molecular_function | transmembrane transporter activity |
B | 0030395 | molecular_function | lactose binding |
B | 0034219 | biological_process | carbohydrate transmembrane transport |
B | 0055085 | biological_process | transmembrane transport |
B | 1902600 | biological_process | proton transmembrane transport |
Functional Information from PROSITE/UniProt
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 144 |
Details | TOPO_DOM: Cytoplasmic => ECO:0000269|PubMed:2164211 |
Chain | Residue | Details |
A | MET1-THR7 | |
B | ALA187-PRO220 | |
B | ALA279-GLY288 | |
B | LYS335-SER346 | |
A | GLY71-LYS74 | |
A | GLU130-PHE140 | |
A | ALA187-PRO220 | |
A | ALA279-GLY288 | |
A | LYS335-SER346 | |
B | MET1-THR7 | |
B | GLY71-LYS74 | |
B | GLU130-PHE140 |
site_id | SWS_FT_FI2 |
Number of Residues | 52 |
Details | TRANSMEM: Helical; Name=1 |
Chain | Residue | Details |
A | ASN8-LEU34 | |
B | ASN8-LEU34 |
site_id | SWS_FT_FI3 |
Number of Residues | 36 |
Details | TOPO_DOM: Periplasmic => ECO:0000269|PubMed:2164211 |
Chain | Residue | Details |
A | HIS35-SER41 | |
B | PHE250-THR253 | |
B | ALA309-SER311 | |
B | SER375-GLY377 | |
A | TYR101-LEU104 | |
A | ILE164-ASN166 | |
A | PHE250-THR253 | |
A | ALA309-SER311 | |
A | SER375-GLY377 | |
B | HIS35-SER41 | |
B | TYR101-LEU104 | |
B | ILE164-ASN166 |
site_id | SWS_FT_FI4 |
Number of Residues | 56 |
Details | TRANSMEM: Helical; Name=2 |
Chain | Residue | Details |
A | LYS42-LEU70 | |
B | LYS42-LEU70 |
site_id | SWS_FT_FI5 |
Number of Residues | 50 |
Details | TRANSMEM: Helical; Name=3 |
Chain | Residue | Details |
A | TYR75-GLN100 | |
B | TYR75-GLN100 |
site_id | SWS_FT_FI6 |
Number of Residues | 48 |
Details | TRANSMEM: Helical; Name=4 |
Chain | Residue | Details |
A | VAL105-ILE129 | |
B | VAL105-ILE129 |
site_id | SWS_FT_FI7 |
Number of Residues | 44 |
Details | TRANSMEM: Helical; Name=5 |
Chain | Residue | Details |
A | GLY141-THR163 | |
B | GLY141-THR163 |
site_id | SWS_FT_FI8 |
Number of Residues | 38 |
Details | TRANSMEM: Helical; Name=6 |
Chain | Residue | Details |
A | GLN167-PHE186 | |
B | GLN167-PHE186 |
site_id | SWS_FT_FI9 |
Number of Residues | 56 |
Details | TRANSMEM: Helical; Name=7 |
Chain | Residue | Details |
A | LYS221-SER249 | |
B | LYS221-SER249 |
site_id | SWS_FT_FI10 |
Number of Residues | 48 |
Details | TRANSMEM: Helical; Name=8 |
Chain | Residue | Details |
A | GLY254-PHE278 | |
B | GLY254-PHE278 |
site_id | SWS_FT_FI11 |
Number of Residues | 38 |
Details | TRANSMEM: Helical; Name=9 |
Chain | Residue | Details |
A | LYS289-PHE308 | |
B | LYS289-PHE308 |
site_id | SWS_FT_FI12 |
Number of Residues | 44 |
Details | TRANSMEM: Helical; Name=10 |
Chain | Residue | Details |
A | ALA312-PHE334 | |
B | ALA312-PHE334 |
site_id | SWS_FT_FI13 |
Number of Residues | 54 |
Details | TRANSMEM: Helical; Name=11 |
Chain | Residue | Details |
A | ALA347-GLU374 | |
B | ALA347-GLU374 |
site_id | SWS_FT_FI14 |
Number of Residues | 40 |
Details | TRANSMEM: Helical; Name=12 |
Chain | Residue | Details |
A | PHE378-PHE398 | |
B | PHE378-PHE398 |
site_id | SWS_FT_FI15 |
Number of Residues | 36 |
Details | TOPO_DOM: Cytoplasmic => ECO:0000269|PubMed:15919996, ECO:0000269|PubMed:2164211 |
Chain | Residue | Details |
A | THR399-ALA417 | |
B | THR399-ALA417 |
site_id | SWS_FT_FI16 |
Number of Residues | 4 |
Details | SITE: Substrate binding => ECO:0000305|PubMed:12893935 |
Chain | Residue | Details |
A | GLU126 | |
A | ARG144 | |
B | GLU126 | |
B | ARG144 |
site_id | SWS_FT_FI17 |
Number of Residues | 2 |
Details | SITE: Substrate binding and proton translocation => ECO:0000305|PubMed:12893935 |
Chain | Residue | Details |
A | GLU269 | |
B | GLU269 |
site_id | SWS_FT_FI18 |
Number of Residues | 6 |
Details | SITE: Proton translocation => ECO:0000305|PubMed:12893935 |
Chain | Residue | Details |
A | ARG302 | |
A | HIS322 | |
A | GLU325 | |
B | ARG302 | |
B | HIS322 | |
B | GLU325 |
site_id | SWS_FT_FI19 |
Number of Residues | 2 |
Details | MOD_RES: N-formylmethionine; partial => ECO:0000269|PubMed:10485888 |
Chain | Residue | Details |
A | MET1 | |
B | MET1 |