1PRX

HORF6 A NOVEL HUMAN PEROXIDASE ENZYME

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003824	molecular_function	catalytic activity
A	0004601	molecular_function	peroxidase activity
A	0004602	molecular_function	glutathione peroxidase activity
A	0004623	molecular_function	A2-type glycerophospholipase activity
A	0005515	molecular_function	protein binding
A	0005576	cellular_component	extracellular region
A	0005615	cellular_component	extracellular space
A	0005634	cellular_component	nucleus
A	0005737	cellular_component	cytoplasm
A	0005764	cellular_component	lysosome
A	0005829	cellular_component	cytosol
A	0006629	biological_process	lipid metabolic process
A	0006979	biological_process	response to oxidative stress
A	0016020	cellular_component	membrane
A	0016042	biological_process	lipid catabolic process
A	0016209	molecular_function	antioxidant activity
A	0016491	molecular_function	oxidoreductase activity
A	0016740	molecular_function	transferase activity
A	0016787	molecular_function	hydrolase activity
A	0031625	molecular_function	ubiquitin protein ligase binding
A	0035578	cellular_component	azurophil granule lumen
A	0042744	biological_process	hydrogen peroxide catabolic process
A	0042802	molecular_function	identical protein binding
A	0045296	molecular_function	cadherin binding
A	0045454	biological_process	cell redox homeostasis
A	0046475	biological_process	glycerophospholipid catabolic process
A	0047184	molecular_function	1-acylglycerophosphocholine O-acyltransferase activity
A	0048026	biological_process	positive regulation of mRNA splicing, via spliceosome
A	0048471	cellular_component	perinuclear region of cytoplasm
A	0051920	molecular_function	peroxiredoxin activity
A	0070062	cellular_component	extracellular exosome
A	0098869	biological_process	cellular oxidant detoxification
B	0003824	molecular_function	catalytic activity
B	0004601	molecular_function	peroxidase activity
B	0004602	molecular_function	glutathione peroxidase activity
B	0004623	molecular_function	A2-type glycerophospholipase activity
B	0005515	molecular_function	protein binding
B	0005576	cellular_component	extracellular region
B	0005615	cellular_component	extracellular space
B	0005634	cellular_component	nucleus
B	0005737	cellular_component	cytoplasm
B	0005764	cellular_component	lysosome
B	0005829	cellular_component	cytosol
B	0006629	biological_process	lipid metabolic process
B	0006979	biological_process	response to oxidative stress
B	0016020	cellular_component	membrane
B	0016042	biological_process	lipid catabolic process
B	0016209	molecular_function	antioxidant activity
B	0016491	molecular_function	oxidoreductase activity
B	0016740	molecular_function	transferase activity
B	0016787	molecular_function	hydrolase activity
B	0031625	molecular_function	ubiquitin protein ligase binding
B	0035578	cellular_component	azurophil granule lumen
B	0042744	biological_process	hydrogen peroxide catabolic process
B	0042802	molecular_function	identical protein binding
B	0045296	molecular_function	cadherin binding
B	0045454	biological_process	cell redox homeostasis
B	0046475	biological_process	glycerophospholipid catabolic process
B	0047184	molecular_function	1-acylglycerophosphocholine O-acyltransferase activity
B	0048026	biological_process	positive regulation of mRNA splicing, via spliceosome
B	0048471	cellular_component	perinuclear region of cytoplasm
B	0051920	molecular_function	peroxiredoxin activity
B	0070062	cellular_component	extracellular exosome
B	0098869	biological_process	cellular oxidant detoxification

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	18
Details	Region: {"description":"Required and sufficient for targeting to lysosomes and lamellar bodies","evidences":[{"source":"UniProtKB","id":"O35244","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	2
Details	Active site: {"description":"Cysteine sulfenic acid (-SOH) intermediate; for peroxidase activity","evidences":[{"source":"PubMed","id":"10893423","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"9497358","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"9587003","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	2
Details	Active site: {"description":"For phospholipase activity","evidences":[{"source":"UniProtKB","id":"O35244","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	2
Details	Site: {"description":"Important for phospholipase activity","evidences":[{"source":"PubMed","id":"10893423","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	2
Details	Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"PubMed","id":"18669648","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"20068231","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	2
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"19608861","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	2
Details	Modified residue: {"description":"Phosphotyrosine","evidences":[{"source":"PubMed","id":"15592455","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	2
Details	Modified residue: {"description":"Phosphothreonine; by MAPK","evidences":[{"source":"UniProtKB","id":"O35244","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI9
Number of Residues	2
Details	Modified residue: {"description":"N6-succinyllysine; alternate","evidences":[{"source":"UniProtKB","id":"O08709","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---