Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

1PQ3

Human Arginase II: Crystal Structure and Physiological Role in Male and Female Sexual Arousal

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004053	molecular_function	arginase activity
A	0006525	biological_process	arginine metabolic process
A	0016813	molecular_function	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines
A	0046872	molecular_function	metal ion binding
B	0004053	molecular_function	arginase activity
B	0006525	biological_process	arginine metabolic process
B	0016813	molecular_function	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines
B	0046872	molecular_function	metal ion binding
C	0004053	molecular_function	arginase activity
C	0006525	biological_process	arginine metabolic process
C	0016813	molecular_function	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines
C	0046872	molecular_function	metal ion binding
D	0004053	molecular_function	arginase activity
D	0006525	biological_process	arginine metabolic process
D	0016813	molecular_function	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines
D	0046872	molecular_function	metal ion binding
E	0004053	molecular_function	arginase activity
E	0006525	biological_process	arginine metabolic process
E	0016813	molecular_function	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines
E	0046872	molecular_function	metal ion binding
F	0004053	molecular_function	arginase activity
F	0006525	biological_process	arginine metabolic process
F	0016813	molecular_function	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines
F	0046872	molecular_function	metal ion binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	2
Details	BINDING SITE FOR RESIDUE SO4 A 3070

Chain	Residue
A	ARG220
A	ARG224

site_id	AC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 F 3071

Chain	Residue
F	ARG220
F	ASP221
F	ARG224
F	HOH973

site_id	AC3
Number of Residues	2
Details	BINDING SITE FOR RESIDUE SO4 D 3072

Chain	Residue
D	ARG220
D	ARG224

site_id	AC4
Number of Residues	2
Details	BINDING SITE FOR RESIDUE SO4 A 3073

Chain	Residue
A	ARG233
A	ARG224

site_id	AC5
Number of Residues	3
Details	BINDING SITE FOR RESIDUE SO4 F 3074

Chain	Residue
F	ARG224
F	LEU225
F	ARG233

site_id	AC6
Number of Residues	2
Details	BINDING SITE FOR RESIDUE SO4 C 3075

Chain	Residue
C	ARG220
C	ARG224

site_id	AC7
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 F 3077

Chain	Residue
F	PRO179
F	GLY180
F	PHE181
F	SER182

site_id	AC8
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 C 3078

Chain	Residue
C	PRO179
C	GLY180
C	PHE181
C	SER182

site_id	AC9
Number of Residues	3
Details	BINDING SITE FOR RESIDUE SO4 D 3079

Chain	Residue
D	GLY180
D	PHE181
D	SER182

site_id	BC1
Number of Residues	2
Details	BINDING SITE FOR RESIDUE SO4 D 3080

Chain	Residue
D	ARG90
D	PRO179

site_id	BC2
Number of Residues	2
Details	BINDING SITE FOR RESIDUE SO4 A 3081

Chain	Residue
A	ARG90
A	PRO179

site_id	BC3
Number of Residues	3
Details	BINDING SITE FOR RESIDUE SO4 A 3082

Chain	Residue
A	GLY180
A	PHE181
A	SER182

site_id	BC4
Number of Residues	3
Details	BINDING SITE FOR RESIDUE SO4 D 3083

Chain	Residue
D	ARG224
D	ARG233
D	HOH1050

site_id	BC5
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 F 3084

Chain	Residue
F	LYS241
F	ARG242
F	ARG244
F	HOH1175

site_id	BC6
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 B 3085

Chain	Residue
B	SER189
B	SER192
B	ARG242
B	ARG244

site_id	BC7
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MN A 500

Chain	Residue
A	HIS120
A	ASP143
A	ASP147
A	ASP251
A	MN501
A	S2C551

site_id	BC8
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MN A 501

Chain	Residue
A	ASP143
A	HIS145
A	ASP251
A	ASP253
A	MN500
A	S2C551

site_id	BC9
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MN B 502

Chain	Residue
B	HIS120
B	ASP143
B	ASP147
B	ASP251
B	MN503
B	S2C552

site_id	CC1
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MN B 503

Chain	Residue
B	ASP143
B	HIS145
B	ASP251
B	ASP253
B	MN502
B	S2C552

site_id	CC2
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MN C 504

Chain	Residue
C	ASP143
C	HIS145
C	ASP251
C	ASP253
C	MN505
C	S2C553

site_id	CC3
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MN C 505

Chain	Residue
C	HIS120
C	ASP143
C	ASP147
C	ASP251
C	MN504
C	S2C553

site_id	CC4
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MN D 506

Chain	Residue
D	HIS120
D	ASP143
D	ASP147
D	ASP251
D	MN507
D	S2C554

site_id	CC5
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MN D 507

Chain	Residue
D	ASP143
D	HIS145
D	ASP251
D	ASP253
D	MN506
D	S2C554

site_id	CC6
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MN E 508

Chain	Residue
E	HIS120
E	ASP143
E	ASP147
E	ASP251
E	MN509
E	S2C555

site_id	CC7
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MN E 509

Chain	Residue
E	HIS145
E	ASP251
E	ASP253
E	MN508
E	S2C555
E	ASP143

site_id	CC8
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MN F 510

Chain	Residue
F	ASP143
F	HIS145
F	ASP251
F	ASP253
F	MN511
F	S2C556

site_id	CC9
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MN F 511

Chain	Residue
F	HIS120
F	ASP143
F	ASP147
F	ASP251
F	MN510
F	S2C556

site_id	DC1
Number of Residues	1
Details	BINDING SITE FOR RESIDUE CL E 600

Chain	Residue
E	ARG242

site_id	DC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE CL A 601

Chain	Residue
C	ARG50
C	GLU51
C	GLY53
C	HOH939

site_id	DC3
Number of Residues	1
Details	BINDING SITE FOR RESIDUE CL C 602

Chain	Residue
C	GLN243

site_id	DC4
Number of Residues	1
Details	BINDING SITE FOR RESIDUE CL F 605

Chain	Residue
F	GLN243

site_id	DC5
Number of Residues	19
Details	BINDING SITE FOR RESIDUE S2C A 551

Chain	Residue
A	HIS120
A	ASP143
A	HIS145
A	ASP147
A	ASN149
A	SER156
A	HIS160
A	GLY161
A	ASP202
A	ASP251
A	ASP253
A	GLU296
A	MN500
A	MN501
A	HOH917
A	HOH918
A	HOH925
A	HOH1076
A	HOH1205

site_id	DC6
Number of Residues	18
Details	BINDING SITE FOR RESIDUE S2C B 552

Chain	Residue
B	HIS120
B	ASP143
B	HIS145
B	ASP147
B	ASN149
B	SER156
B	HIS160
B	GLY161
B	ASP202
B	ASP251
B	ASP253
B	THR265
B	GLU296
B	MN502
B	MN503
B	HOH920
B	HOH921
B	HOH999

site_id	DC7
Number of Residues	19
Details	BINDING SITE FOR RESIDUE S2C C 553

Chain	Residue
C	HIS120
C	ASP143
C	HIS145
C	ASP147
C	ASN149
C	THR154
C	SER156
C	HIS160
C	ASP202
C	ASP251
C	ASP253
C	THR265
C	GLU296
C	MN504
C	MN505
C	HOH922
C	HOH923
C	HOH1077
C	HOH1147

site_id	DC8
Number of Residues	18
Details	BINDING SITE FOR RESIDUE S2C D 554

Chain	Residue
D	HIS120
D	ASP143
D	HIS145
D	ASP147
D	ASN149
D	SER156
D	HIS160
D	GLY161
D	ASP202
D	ASP251
D	ASP253
D	GLU296
D	MN506
D	MN507
D	HOH924
D	HOH926
D	HOH927
D	HOH1078

site_id	DC9
Number of Residues	20
Details	BINDING SITE FOR RESIDUE S2C E 555

Chain	Residue
E	HIS120
E	ASP143
E	HIS145
E	ASP147
E	ASN149
E	SER156
E	HIS160
E	GLY161
E	ASP202
E	ASP251
E	ASP253
E	THR265
E	GLU296
E	MN508
E	MN509
E	HOH931
E	HOH932
E	HOH933
E	HOH1053
E	HOH1056

site_id	EC1
Number of Residues	19
Details	BINDING SITE FOR RESIDUE S2C F 556

Chain	Residue
F	HIS120
F	ASP143
F	HIS145
F	ASP147
F	ASN149
F	SER156
F	HIS160
F	ASP202
F	ASP251
F	ASP253
F	THR265
F	GLU296
F	MN510
F	MN511
F	HOH928
F	HOH929
F	HOH930
F	HOH1054
F	HOH1148

Functional Information from PROSITE/UniProt

site_id	PS01053
Number of Residues	22
Details	ARGINASE_1 Arginase family signature. SFDIDafdPtlaPAtgtpvvgG

Chain	Residue	Details
A	SER249-GLY270

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	84
Details	Binding site: {"evidences":[{"source":"PubMed","id":"12859189","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1PQ3","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4HZE","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4I06","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4IE2","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4IE3","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4IXU","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4IXV","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	6
Details	Binding site: {"evidences":[{"source":"UniProtKB","id":"P53608","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

Catalytic Information from CSA

site_id	CSA1
Number of Residues	2
Details	Annotated By Reference To The Literature 1cev

Chain	Residue	Details
A	GLU296
A	ASP147

site_id	CSA2
Number of Residues	2
Details	Annotated By Reference To The Literature 1cev

Chain	Residue	Details
B	GLU296
B	ASP147

site_id	CSA3
Number of Residues	2
Details	Annotated By Reference To The Literature 1cev

Chain	Residue	Details
C	GLU296
C	ASP147

site_id	CSA4
Number of Residues	2
Details	Annotated By Reference To The Literature 1cev

Chain	Residue	Details
D	GLU296
D	ASP147

site_id	CSA5
Number of Residues	2
Details	Annotated By Reference To The Literature 1cev

Chain	Residue	Details
E	GLU296
E	ASP147

site_id	CSA6
Number of Residues	2
Details	Annotated By Reference To The Literature 1cev

Chain	Residue	Details
F	GLU296
F	ASP147

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)