1POA
INTERFACIAL CATALYSIS: THE MECHANISM OF PHOSPHOLIPASE A2
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004623 | molecular_function | phospholipase A2 activity |
| A | 0005102 | molecular_function | signaling receptor binding |
| A | 0005509 | molecular_function | calcium ion binding |
| A | 0005543 | molecular_function | phospholipid binding |
| A | 0005576 | cellular_component | extracellular region |
| A | 0006629 | biological_process | lipid metabolic process |
| A | 0006633 | biological_process | fatty acid biosynthetic process |
| A | 0006644 | biological_process | phospholipid metabolic process |
| A | 0016042 | biological_process | lipid catabolic process |
| A | 0016787 | molecular_function | hydrolase activity |
| A | 0035821 | biological_process | modulation of process of another organism |
| A | 0046872 | molecular_function | metal ion binding |
| A | 0047498 | molecular_function | calcium-dependent phospholipase A2 activity |
| A | 0048146 | biological_process | positive regulation of fibroblast proliferation |
| A | 0050482 | biological_process | arachidonate secretion |
| A | 0090729 | molecular_function | toxin activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE CA A 201 |
| Chain | Residue |
| A | ASP48 |
| A | HOH202 |
| A | HOH203 |
| A | TYR27 |
| A | GLY29 |
| A | GLY31 |
| site_id | AC2 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE CA A 401 |
| Chain | Residue |
| A | ASP23 |
| A | ASN111 |
| A | HOH238 |
| A | HOH239 |
| A | HOH240 |
| A | HOH247 |
| site_id | CA1 |
| Number of Residues | 4 |
| Details |
| Chain | Residue |
| A | CYS28 |
| A | ARG30 |
| A | GLY32 |
| A | ASN49 |
| site_id | CA2 |
| Number of Residues | 2 |
| Details |
| Chain | Residue |
| A | ASP23 |
| A | ASN111 |
Functional Information from PROSITE/UniProt
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | Active site: {"evidences":[{"source":"PubMed","id":"2274785","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 4 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"2274785","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"2274787","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1POA","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1POB","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1n29 |
| Chain | Residue | Details |
| A | HIS47 | |
| A | ASP93 | |
| A | GLY29 |
