1PN0
Phenol hydroxylase from Trichosporon cutaneum
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004497 | molecular_function | monooxygenase activity |
| A | 0016491 | molecular_function | oxidoreductase activity |
| A | 0016709 | molecular_function | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen |
| A | 0018662 | molecular_function | phenol 2-monooxygenase activity |
| A | 0019336 | biological_process | phenol-containing compound catabolic process |
| A | 0019439 | biological_process | obsolete aromatic compound catabolic process |
| A | 0071949 | molecular_function | FAD binding |
| B | 0004497 | molecular_function | monooxygenase activity |
| B | 0016491 | molecular_function | oxidoreductase activity |
| B | 0016709 | molecular_function | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen |
| B | 0018662 | molecular_function | phenol 2-monooxygenase activity |
| B | 0019336 | biological_process | phenol-containing compound catabolic process |
| B | 0019439 | biological_process | obsolete aromatic compound catabolic process |
| B | 0071949 | molecular_function | FAD binding |
| C | 0004497 | molecular_function | monooxygenase activity |
| C | 0016491 | molecular_function | oxidoreductase activity |
| C | 0016709 | molecular_function | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen |
| C | 0018662 | molecular_function | phenol 2-monooxygenase activity |
| C | 0019336 | biological_process | phenol-containing compound catabolic process |
| C | 0019439 | biological_process | obsolete aromatic compound catabolic process |
| C | 0071949 | molecular_function | FAD binding |
| D | 0004497 | molecular_function | monooxygenase activity |
| D | 0016491 | molecular_function | oxidoreductase activity |
| D | 0016709 | molecular_function | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen |
| D | 0018662 | molecular_function | phenol 2-monooxygenase activity |
| D | 0019336 | biological_process | phenol-containing compound catabolic process |
| D | 0019439 | biological_process | obsolete aromatic compound catabolic process |
| D | 0071949 | molecular_function | FAD binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE CL A 6001 |
| Chain | Residue |
| A | LYS65 |
| A | GLY68 |
| A | LEU69 |
| A | ALA70 |
| A | ASP71 |
| A | HOH6561 |
| A | HOH6576 |
| site_id | AC2 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE CL B 6002 |
| Chain | Residue |
| B | LEU69 |
| B | ALA70 |
| B | ASP71 |
| B | HOH1245 |
| B | LYS65 |
| B | GLY68 |
| site_id | AC3 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE CL C 6003 |
| Chain | Residue |
| C | LYS65 |
| C | GLY68 |
| C | LEU69 |
| C | ALA70 |
| C | ASP71 |
| C | HOH6600 |
| C | HOH6615 |
| site_id | AC4 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE CL D 6004 |
| Chain | Residue |
| D | LYS65 |
| D | GLY68 |
| D | LEU69 |
| D | ALA70 |
| D | ASP71 |
| D | HOH6602 |
| D | HOH6617 |
| site_id | AC5 |
| Number of Residues | 37 |
| Details | BINDING SITE FOR RESIDUE FAD A 6011 |
| Chain | Residue |
| A | VAL13 |
| A | GLY14 |
| A | GLY16 |
| A | PRO17 |
| A | ALA18 |
| A | ASP42 |
| A | LYS43 |
| A | ARG44 |
| A | ALA53 |
| A | GLN117 |
| A | LEU142 |
| A | PRO144 |
| A | CYS224 |
| A | ASP225 |
| A | GLY226 |
| A | ARG287 |
| A | TYR289 |
| A | TRP332 |
| A | GLY356 |
| A | ASP357 |
| A | PRO364 |
| A | GLY369 |
| A | MET370 |
| A | SER373 |
| A | HOH6022 |
| A | HOH6030 |
| A | HOH6051 |
| A | HOH6067 |
| A | HOH6093 |
| A | HOH6103 |
| A | HOH6120 |
| A | HOH6403 |
| A | HOH6408 |
| A | HOH6415 |
| A | HOH6542 |
| A | HOH6585 |
| A | HOH6586 |
| site_id | AC6 |
| Number of Residues | 10 |
| Details | BINDING SITE FOR RESIDUE IPH A 6012 |
| Chain | Residue |
| A | ASP54 |
| A | GLN112 |
| A | VAL114 |
| A | MET277 |
| A | ILE279 |
| A | TYR289 |
| A | PRO364 |
| A | LYS365 |
| A | ALA366 |
| A | GLY367 |
| site_id | AC7 |
| Number of Residues | 35 |
| Details | BINDING SITE FOR RESIDUE FAD B 6021 |
| Chain | Residue |
| B | HOH706 |
| B | HOH722 |
| B | HOH748 |
| B | HOH758 |
| B | HOH1057 |
| B | HOH1062 |
| B | HOH1069 |
| B | HOH1215 |
| B | HOH1254 |
| B | HOH1255 |
| B | GLY14 |
| B | GLY16 |
| B | PRO17 |
| B | ALA18 |
| B | ASP42 |
| B | LYS43 |
| B | ARG44 |
| B | ALA53 |
| B | GLN117 |
| B | LEU142 |
| B | PRO144 |
| B | CYS224 |
| B | ASP225 |
| B | GLY226 |
| B | ARG287 |
| B | TYR289 |
| B | TRP332 |
| B | GLY356 |
| B | ASP357 |
| B | PRO364 |
| B | GLY369 |
| B | MET370 |
| B | SER373 |
| B | HOH677 |
| B | HOH685 |
| site_id | AC8 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE IPH B 6022 |
| Chain | Residue |
| B | ASP54 |
| B | GLN112 |
| B | VAL114 |
| B | MET277 |
| B | ILE279 |
| B | TYR289 |
| B | PRO364 |
| B | ALA366 |
| B | GLY367 |
| site_id | AC9 |
| Number of Residues | 38 |
| Details | BINDING SITE FOR RESIDUE FAD C 6031 |
| Chain | Residue |
| C | GLY14 |
| C | GLY16 |
| C | PRO17 |
| C | ALA18 |
| C | ASP42 |
| C | LYS43 |
| C | ARG44 |
| C | ASN50 |
| C | GLN52 |
| C | ALA53 |
| C | ASP54 |
| C | GLY55 |
| C | LEU142 |
| C | PRO144 |
| C | ARG189 |
| C | CYS224 |
| C | ASP225 |
| C | GLY226 |
| C | ARG287 |
| C | TYR289 |
| C | GLY356 |
| C | ASP357 |
| C | PRO364 |
| C | GLY367 |
| C | GLN368 |
| C | GLY369 |
| C | MET370 |
| C | ASN371 |
| C | SER373 |
| C | IPH6032 |
| C | HOH6044 |
| C | HOH6052 |
| C | HOH6073 |
| C | HOH6099 |
| C | HOH6102 |
| C | HOH6149 |
| C | HOH6438 |
| C | HOH6443 |
| site_id | BC1 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE IPH C 6032 |
| Chain | Residue |
| C | ASP54 |
| C | GLN112 |
| C | VAL114 |
| C | MET277 |
| C | TYR289 |
| C | PRO364 |
| C | ALA366 |
| C | GLY367 |
| C | FAD6031 |
| site_id | BC2 |
| Number of Residues | 39 |
| Details | BINDING SITE FOR RESIDUE FAD D 6041 |
| Chain | Residue |
| D | GLY14 |
| D | GLY16 |
| D | PRO17 |
| D | ALA18 |
| D | ASP42 |
| D | LYS43 |
| D | ARG44 |
| D | ASN50 |
| D | GLN52 |
| D | ALA53 |
| D | ASP54 |
| D | GLY55 |
| D | LEU142 |
| D | ILE143 |
| D | PRO144 |
| D | ARG189 |
| D | CYS224 |
| D | ASP225 |
| D | GLY226 |
| D | ARG287 |
| D | TYR289 |
| D | GLY356 |
| D | ASP357 |
| D | PRO364 |
| D | GLY367 |
| D | GLN368 |
| D | GLY369 |
| D | MET370 |
| D | ASN371 |
| D | SER373 |
| D | IPH6042 |
| D | HOH6062 |
| D | HOH6070 |
| D | HOH6091 |
| D | HOH6117 |
| D | HOH6120 |
| D | HOH6160 |
| D | HOH6462 |
| D | HOH6467 |
| site_id | BC3 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE IPH D 6042 |
| Chain | Residue |
| D | ASP54 |
| D | GLN112 |
| D | MET277 |
| D | ILE279 |
| D | TYR289 |
| D | PRO364 |
| D | ALA366 |
| D | GLY367 |
| D | FAD6041 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 28 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:12925790, ECO:0000269|PubMed:9634698, ECO:0007744|PDB:1FOH, ECO:0007744|PDB:1PN0 |
| Chain | Residue | Details |
| A | ALA18 | |
| B | GLY51 | |
| B | GLY55 | |
| B | GLY118 | |
| B | VAL290 | |
| B | GLN368 | |
| C | ALA18 | |
| C | LYS43 | |
| C | GLY51 | |
| C | GLY55 | |
| C | GLY118 | |
| A | LYS43 | |
| C | VAL290 | |
| C | GLN368 | |
| D | ALA18 | |
| D | LYS43 | |
| D | GLY51 | |
| D | GLY55 | |
| D | GLY118 | |
| D | VAL290 | |
| D | GLN368 | |
| A | GLY51 | |
| A | GLY55 | |
| A | GLY118 | |
| A | VAL290 | |
| A | GLN368 | |
| B | ALA18 | |
| B | LYS43 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 4 |
| Details | BINDING: BINDING => ECO:0007744|PDB:1FOH, ECO:0007744|PDB:1PN0 |
| Chain | Residue | Details |
| A | ALA358 | |
| B | ALA358 | |
| C | ALA358 | |
| D | ALA358 |
Catalytic Information from CSA
| site_id | MCSA1 |
| Number of Residues | 4 |
| Details | M-CSA 551 |
| Chain | Residue | Details |
| A | GLY55 | electrostatic stabiliser |
| A | GLU282 | electrostatic stabiliser |
| A | VAL290 | steric role |
| A | LYS365 | activator, electrostatic stabiliser |
| site_id | MCSA2 |
| Number of Residues | 4 |
| Details | M-CSA 551 |
| Chain | Residue | Details |
| B | GLY55 | electrostatic stabiliser |
| B | GLU282 | electrostatic stabiliser |
| B | VAL290 | steric role |
| B | LYS365 | activator, electrostatic stabiliser |
| site_id | MCSA3 |
| Number of Residues | 4 |
| Details | M-CSA 551 |
| Chain | Residue | Details |
| C | GLY55 | electrostatic stabiliser |
| C | GLU282 | electrostatic stabiliser |
| C | VAL290 | steric role |
| C | LYS365 | activator, electrostatic stabiliser |
| site_id | MCSA4 |
| Number of Residues | 4 |
| Details | M-CSA 551 |
| Chain | Residue | Details |
| D | GLY55 | electrostatic stabiliser |
| D | GLU282 | electrostatic stabiliser |
| D | VAL290 | steric role |
| D | LYS365 | activator, electrostatic stabiliser |
