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1PMA

PROTEASOME FROM THERMOPLASMA ACIDOPHILUM

Functional Information from GO Data
ChainGOidnamespacecontents
10000502cellular_componentproteasome complex
10004175molecular_functionendopeptidase activity
10004298molecular_functionthreonine-type endopeptidase activity
10005737cellular_componentcytoplasm
10005839cellular_componentproteasome core complex
10006508biological_processproteolysis
10008233molecular_functionpeptidase activity
10010498biological_processproteasomal protein catabolic process
10016787molecular_functionhydrolase activity
10019774cellular_componentproteasome core complex, beta-subunit complex
10051603biological_processproteolysis involved in protein catabolic process
20000502cellular_componentproteasome complex
20004175molecular_functionendopeptidase activity
20004298molecular_functionthreonine-type endopeptidase activity
20005737cellular_componentcytoplasm
20005839cellular_componentproteasome core complex
20006508biological_processproteolysis
20008233molecular_functionpeptidase activity
20010498biological_processproteasomal protein catabolic process
20016787molecular_functionhydrolase activity
20019774cellular_componentproteasome core complex, beta-subunit complex
20051603biological_processproteolysis involved in protein catabolic process
A0000502cellular_componentproteasome complex
A0004175molecular_functionendopeptidase activity
A0004298molecular_functionthreonine-type endopeptidase activity
A0005737cellular_componentcytoplasm
A0005839cellular_componentproteasome core complex
A0006511biological_processubiquitin-dependent protein catabolic process
A0010498biological_processproteasomal protein catabolic process
A0019773cellular_componentproteasome core complex, alpha-subunit complex
A0051603biological_processproteolysis involved in protein catabolic process
B0000502cellular_componentproteasome complex
B0004175molecular_functionendopeptidase activity
B0004298molecular_functionthreonine-type endopeptidase activity
B0005737cellular_componentcytoplasm
B0005839cellular_componentproteasome core complex
B0006508biological_processproteolysis
B0008233molecular_functionpeptidase activity
B0010498biological_processproteasomal protein catabolic process
B0016787molecular_functionhydrolase activity
B0019774cellular_componentproteasome core complex, beta-subunit complex
B0051603biological_processproteolysis involved in protein catabolic process
C0000502cellular_componentproteasome complex
C0004175molecular_functionendopeptidase activity
C0004298molecular_functionthreonine-type endopeptidase activity
C0005737cellular_componentcytoplasm
C0005839cellular_componentproteasome core complex
C0006511biological_processubiquitin-dependent protein catabolic process
C0010498biological_processproteasomal protein catabolic process
C0019773cellular_componentproteasome core complex, alpha-subunit complex
C0051603biological_processproteolysis involved in protein catabolic process
D0000502cellular_componentproteasome complex
D0004175molecular_functionendopeptidase activity
D0004298molecular_functionthreonine-type endopeptidase activity
D0005737cellular_componentcytoplasm
D0005839cellular_componentproteasome core complex
D0006511biological_processubiquitin-dependent protein catabolic process
D0010498biological_processproteasomal protein catabolic process
D0019773cellular_componentproteasome core complex, alpha-subunit complex
D0051603biological_processproteolysis involved in protein catabolic process
E0000502cellular_componentproteasome complex
E0004175molecular_functionendopeptidase activity
E0004298molecular_functionthreonine-type endopeptidase activity
E0005737cellular_componentcytoplasm
E0005839cellular_componentproteasome core complex
E0006511biological_processubiquitin-dependent protein catabolic process
E0010498biological_processproteasomal protein catabolic process
E0019773cellular_componentproteasome core complex, alpha-subunit complex
E0051603biological_processproteolysis involved in protein catabolic process
F0000502cellular_componentproteasome complex
F0004175molecular_functionendopeptidase activity
F0004298molecular_functionthreonine-type endopeptidase activity
F0005737cellular_componentcytoplasm
F0005839cellular_componentproteasome core complex
F0006511biological_processubiquitin-dependent protein catabolic process
F0010498biological_processproteasomal protein catabolic process
F0019773cellular_componentproteasome core complex, alpha-subunit complex
F0051603biological_processproteolysis involved in protein catabolic process
G0000502cellular_componentproteasome complex
G0004175molecular_functionendopeptidase activity
G0004298molecular_functionthreonine-type endopeptidase activity
G0005737cellular_componentcytoplasm
G0005839cellular_componentproteasome core complex
G0006511biological_processubiquitin-dependent protein catabolic process
G0010498biological_processproteasomal protein catabolic process
G0019773cellular_componentproteasome core complex, alpha-subunit complex
G0051603biological_processproteolysis involved in protein catabolic process
H0000502cellular_componentproteasome complex
H0004175molecular_functionendopeptidase activity
H0004298molecular_functionthreonine-type endopeptidase activity
H0005737cellular_componentcytoplasm
H0005839cellular_componentproteasome core complex
H0006511biological_processubiquitin-dependent protein catabolic process
H0010498biological_processproteasomal protein catabolic process
H0019773cellular_componentproteasome core complex, alpha-subunit complex
H0051603biological_processproteolysis involved in protein catabolic process
I0000502cellular_componentproteasome complex
I0004175molecular_functionendopeptidase activity
I0004298molecular_functionthreonine-type endopeptidase activity
I0005737cellular_componentcytoplasm
I0005839cellular_componentproteasome core complex
I0006511biological_processubiquitin-dependent protein catabolic process
I0010498biological_processproteasomal protein catabolic process
I0019773cellular_componentproteasome core complex, alpha-subunit complex
I0051603biological_processproteolysis involved in protein catabolic process
J0000502cellular_componentproteasome complex
J0004175molecular_functionendopeptidase activity
J0004298molecular_functionthreonine-type endopeptidase activity
J0005737cellular_componentcytoplasm
J0005839cellular_componentproteasome core complex
J0006511biological_processubiquitin-dependent protein catabolic process
J0010498biological_processproteasomal protein catabolic process
J0019773cellular_componentproteasome core complex, alpha-subunit complex
J0051603biological_processproteolysis involved in protein catabolic process
K0000502cellular_componentproteasome complex
K0004175molecular_functionendopeptidase activity
K0004298molecular_functionthreonine-type endopeptidase activity
K0005737cellular_componentcytoplasm
K0005839cellular_componentproteasome core complex
K0006511biological_processubiquitin-dependent protein catabolic process
K0010498biological_processproteasomal protein catabolic process
K0019773cellular_componentproteasome core complex, alpha-subunit complex
K0051603biological_processproteolysis involved in protein catabolic process
L0000502cellular_componentproteasome complex
L0004175molecular_functionendopeptidase activity
L0004298molecular_functionthreonine-type endopeptidase activity
L0005737cellular_componentcytoplasm
L0005839cellular_componentproteasome core complex
L0006511biological_processubiquitin-dependent protein catabolic process
L0010498biological_processproteasomal protein catabolic process
L0019773cellular_componentproteasome core complex, alpha-subunit complex
L0051603biological_processproteolysis involved in protein catabolic process
M0000502cellular_componentproteasome complex
M0004175molecular_functionendopeptidase activity
M0004298molecular_functionthreonine-type endopeptidase activity
M0005737cellular_componentcytoplasm
M0005839cellular_componentproteasome core complex
M0006511biological_processubiquitin-dependent protein catabolic process
M0010498biological_processproteasomal protein catabolic process
M0019773cellular_componentproteasome core complex, alpha-subunit complex
M0051603biological_processproteolysis involved in protein catabolic process
N0000502cellular_componentproteasome complex
N0004175molecular_functionendopeptidase activity
N0004298molecular_functionthreonine-type endopeptidase activity
N0005737cellular_componentcytoplasm
N0005839cellular_componentproteasome core complex
N0006511biological_processubiquitin-dependent protein catabolic process
N0010498biological_processproteasomal protein catabolic process
N0019773cellular_componentproteasome core complex, alpha-subunit complex
N0051603biological_processproteolysis involved in protein catabolic process
O0000502cellular_componentproteasome complex
O0004175molecular_functionendopeptidase activity
O0004298molecular_functionthreonine-type endopeptidase activity
O0005737cellular_componentcytoplasm
O0005839cellular_componentproteasome core complex
O0006511biological_processubiquitin-dependent protein catabolic process
O0010498biological_processproteasomal protein catabolic process
O0019773cellular_componentproteasome core complex, alpha-subunit complex
O0051603biological_processproteolysis involved in protein catabolic process
P0000502cellular_componentproteasome complex
P0004175molecular_functionendopeptidase activity
P0004298molecular_functionthreonine-type endopeptidase activity
P0005737cellular_componentcytoplasm
P0005839cellular_componentproteasome core complex
P0006508biological_processproteolysis
P0008233molecular_functionpeptidase activity
P0010498biological_processproteasomal protein catabolic process
P0016787molecular_functionhydrolase activity
P0019774cellular_componentproteasome core complex, beta-subunit complex
P0051603biological_processproteolysis involved in protein catabolic process
Q0000502cellular_componentproteasome complex
Q0004175molecular_functionendopeptidase activity
Q0004298molecular_functionthreonine-type endopeptidase activity
Q0005737cellular_componentcytoplasm
Q0005839cellular_componentproteasome core complex
Q0006508biological_processproteolysis
Q0008233molecular_functionpeptidase activity
Q0010498biological_processproteasomal protein catabolic process
Q0016787molecular_functionhydrolase activity
Q0019774cellular_componentproteasome core complex, beta-subunit complex
Q0051603biological_processproteolysis involved in protein catabolic process
R0000502cellular_componentproteasome complex
R0004175molecular_functionendopeptidase activity
R0004298molecular_functionthreonine-type endopeptidase activity
R0005737cellular_componentcytoplasm
R0005839cellular_componentproteasome core complex
R0006508biological_processproteolysis
R0008233molecular_functionpeptidase activity
R0010498biological_processproteasomal protein catabolic process
R0016787molecular_functionhydrolase activity
R0019774cellular_componentproteasome core complex, beta-subunit complex
R0051603biological_processproteolysis involved in protein catabolic process
S0000502cellular_componentproteasome complex
S0004175molecular_functionendopeptidase activity
S0004298molecular_functionthreonine-type endopeptidase activity
S0005737cellular_componentcytoplasm
S0005839cellular_componentproteasome core complex
S0006508biological_processproteolysis
S0008233molecular_functionpeptidase activity
S0010498biological_processproteasomal protein catabolic process
S0016787molecular_functionhydrolase activity
S0019774cellular_componentproteasome core complex, beta-subunit complex
S0051603biological_processproteolysis involved in protein catabolic process
T0000502cellular_componentproteasome complex
T0004175molecular_functionendopeptidase activity
T0004298molecular_functionthreonine-type endopeptidase activity
T0005737cellular_componentcytoplasm
T0005839cellular_componentproteasome core complex
T0006508biological_processproteolysis
T0008233molecular_functionpeptidase activity
T0010498biological_processproteasomal protein catabolic process
T0016787molecular_functionhydrolase activity
T0019774cellular_componentproteasome core complex, beta-subunit complex
T0051603biological_processproteolysis involved in protein catabolic process
U0000502cellular_componentproteasome complex
U0004175molecular_functionendopeptidase activity
U0004298molecular_functionthreonine-type endopeptidase activity
U0005737cellular_componentcytoplasm
U0005839cellular_componentproteasome core complex
U0006508biological_processproteolysis
U0008233molecular_functionpeptidase activity
U0010498biological_processproteasomal protein catabolic process
U0016787molecular_functionhydrolase activity
U0019774cellular_componentproteasome core complex, beta-subunit complex
U0051603biological_processproteolysis involved in protein catabolic process
V0000502cellular_componentproteasome complex
V0004175molecular_functionendopeptidase activity
V0004298molecular_functionthreonine-type endopeptidase activity
V0005737cellular_componentcytoplasm
V0005839cellular_componentproteasome core complex
V0006508biological_processproteolysis
V0008233molecular_functionpeptidase activity
V0010498biological_processproteasomal protein catabolic process
V0016787molecular_functionhydrolase activity
V0019774cellular_componentproteasome core complex, beta-subunit complex
V0051603biological_processproteolysis involved in protein catabolic process
W0000502cellular_componentproteasome complex
W0004175molecular_functionendopeptidase activity
W0004298molecular_functionthreonine-type endopeptidase activity
W0005737cellular_componentcytoplasm
W0005839cellular_componentproteasome core complex
W0006508biological_processproteolysis
W0008233molecular_functionpeptidase activity
W0010498biological_processproteasomal protein catabolic process
W0016787molecular_functionhydrolase activity
W0019774cellular_componentproteasome core complex, beta-subunit complex
W0051603biological_processproteolysis involved in protein catabolic process
X0000502cellular_componentproteasome complex
X0004175molecular_functionendopeptidase activity
X0004298molecular_functionthreonine-type endopeptidase activity
X0005737cellular_componentcytoplasm
X0005839cellular_componentproteasome core complex
X0006508biological_processproteolysis
X0008233molecular_functionpeptidase activity
X0010498biological_processproteasomal protein catabolic process
X0016787molecular_functionhydrolase activity
X0019774cellular_componentproteasome core complex, beta-subunit complex
X0051603biological_processproteolysis involved in protein catabolic process
Y0000502cellular_componentproteasome complex
Y0004175molecular_functionendopeptidase activity
Y0004298molecular_functionthreonine-type endopeptidase activity
Y0005737cellular_componentcytoplasm
Y0005839cellular_componentproteasome core complex
Y0006508biological_processproteolysis
Y0008233molecular_functionpeptidase activity
Y0010498biological_processproteasomal protein catabolic process
Y0016787molecular_functionhydrolase activity
Y0019774cellular_componentproteasome core complex, beta-subunit complex
Y0051603biological_processproteolysis involved in protein catabolic process
Z0000502cellular_componentproteasome complex
Z0004175molecular_functionendopeptidase activity
Z0004298molecular_functionthreonine-type endopeptidase activity
Z0005737cellular_componentcytoplasm
Z0005839cellular_componentproteasome core complex
Z0006508biological_processproteolysis
Z0008233molecular_functionpeptidase activity
Z0010498biological_processproteasomal protein catabolic process
Z0016787molecular_functionhydrolase activity
Z0019774cellular_componentproteasome core complex, beta-subunit complex
Z0051603biological_processproteolysis involved in protein catabolic process
Functional Information from PROSITE/UniProt
site_idPS00388
Number of Residues23
DetailsPROTEASOME_ALPHA_1 Proteasome alpha-type subunits signature. YdraiTvFSPdGRlfQVEYAreA
ChainResidueDetails
ATYR8-ALA30

site_idPS00854
Number of Residues48
DetailsPROTEASOME_BETA_1 Proteasome beta-type subunits signature. VGItLkdAVIMATErrvtmenfimhkngk.KlfqidtytgmtiaGlvGD
ChainResidueDetails
1VAL4-ASP51

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues14
DetailsActive site: {"description":"Nucleophile","evidences":[{"source":"HAMAP-Rule","id":"MF_02113","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"7725107","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails

Catalytic Information from CSA
site_idCSA1
Number of Residues6
Detailsa catalytic site defined by CSA, PubMed 7725097, 7725107, 8684489, 12614609, 9642094, 9087403, 10500111, 15678420
ChainResidueDetails
BGLY47
BLYS33
BTHR1
BTHR1
BSER129
BSER129

site_idCSA10
Number of Residues6
Detailsa catalytic site defined by CSA, PubMed 7725097, 7725107, 8684489, 12614609, 9642094, 9087403, 10500111, 15678420
ChainResidueDetails
XGLY47
XLYS33
XTHR1
XTHR1
XSER129
XSER129

site_idCSA11
Number of Residues6
Detailsa catalytic site defined by CSA, PubMed 7725097, 7725107, 8684489, 12614609, 9642094, 9087403, 10500111, 15678420
ChainResidueDetails
YGLY47
YLYS33
YTHR1
YTHR1
YSER129
YSER129

site_idCSA12
Number of Residues6
Detailsa catalytic site defined by CSA, PubMed 7725097, 7725107, 8684489, 12614609, 9642094, 9087403, 10500111, 15678420
ChainResidueDetails
ZGLY47
ZLYS33
ZTHR1
ZTHR1
ZSER129
ZSER129

site_idCSA13
Number of Residues6
Detailsa catalytic site defined by CSA, PubMed 7725097, 7725107, 8684489, 12614609, 9642094, 9087403, 10500111, 15678420
ChainResidueDetails
1GLY47
1LYS33
1THR1
1THR1
1SER129
1SER129

site_idCSA14
Number of Residues6
Detailsa catalytic site defined by CSA, PubMed 7725097, 7725107, 8684489, 12614609, 9642094, 9087403, 10500111, 15678420
ChainResidueDetails
2GLY47
2LYS33
2THR1
2THR1
2SER129
2SER129

site_idCSA15
Number of Residues6
Detailsa catalytic site defined by CSA, PubMed 7725097, 7725107, 8684489, 12614609, 9642094, 9087403, 10500111, 15678420
ChainResidueDetails
AGLY80
ASER35
ASER35
ASER167
ASER167
ALYS66

site_idCSA16
Number of Residues6
Detailsa catalytic site defined by CSA, PubMed 7725097, 7725107, 8684489, 12614609, 9642094, 9087403, 10500111, 15678420
ChainResidueDetails
CGLY80
CSER35
CSER35
CSER167
CSER167
CLYS66

site_idCSA17
Number of Residues6
Detailsa catalytic site defined by CSA, PubMed 7725097, 7725107, 8684489, 12614609, 9642094, 9087403, 10500111, 15678420
ChainResidueDetails
DGLY80
DSER35
DSER35
DSER167
DSER167
DLYS66

site_idCSA18
Number of Residues6
Detailsa catalytic site defined by CSA, PubMed 7725097, 7725107, 8684489, 12614609, 9642094, 9087403, 10500111, 15678420
ChainResidueDetails
EGLY80
ESER35
ESER35
ESER167
ESER167
ELYS66

site_idCSA19
Number of Residues6
Detailsa catalytic site defined by CSA, PubMed 7725097, 7725107, 8684489, 12614609, 9642094, 9087403, 10500111, 15678420
ChainResidueDetails
FGLY80
FSER35
FSER35
FSER167
FSER167
FLYS66

site_idCSA2
Number of Residues6
Detailsa catalytic site defined by CSA, PubMed 7725097, 7725107, 8684489, 12614609, 9642094, 9087403, 10500111, 15678420
ChainResidueDetails
PGLY47
PLYS33
PTHR1
PTHR1
PSER129
PSER129

site_idCSA20
Number of Residues6
Detailsa catalytic site defined by CSA, PubMed 7725097, 7725107, 8684489, 12614609, 9642094, 9087403, 10500111, 15678420
ChainResidueDetails
GGLY80
GSER35
GSER35
GSER167
GSER167
GLYS66

site_idCSA21
Number of Residues6
Detailsa catalytic site defined by CSA, PubMed 7725097, 7725107, 8684489, 12614609, 9642094, 9087403, 10500111, 15678420
ChainResidueDetails
HGLY80
HSER35
HSER35
HSER167
HSER167
HLYS66

site_idCSA22
Number of Residues6
Detailsa catalytic site defined by CSA, PubMed 7725097, 7725107, 8684489, 12614609, 9642094, 9087403, 10500111, 15678420
ChainResidueDetails
IGLY80
ISER35
ISER35
ISER167
ISER167
ILYS66

site_idCSA23
Number of Residues6
Detailsa catalytic site defined by CSA, PubMed 7725097, 7725107, 8684489, 12614609, 9642094, 9087403, 10500111, 15678420
ChainResidueDetails
JGLY80
JSER35
JSER35
JSER167
JSER167
JLYS66

site_idCSA24
Number of Residues6
Detailsa catalytic site defined by CSA, PubMed 7725097, 7725107, 8684489, 12614609, 9642094, 9087403, 10500111, 15678420
ChainResidueDetails
KGLY80
KSER35
KSER35
KSER167
KSER167
KLYS66

site_idCSA25
Number of Residues6
Detailsa catalytic site defined by CSA, PubMed 7725097, 7725107, 8684489, 12614609, 9642094, 9087403, 10500111, 15678420
ChainResidueDetails
LGLY80
LSER35
LSER35
LSER167
LSER167
LLYS66

site_idCSA26
Number of Residues6
Detailsa catalytic site defined by CSA, PubMed 7725097, 7725107, 8684489, 12614609, 9642094, 9087403, 10500111, 15678420
ChainResidueDetails
MGLY80
MSER35
MSER35
MSER167
MSER167
MLYS66

site_idCSA27
Number of Residues6
Detailsa catalytic site defined by CSA, PubMed 7725097, 7725107, 8684489, 12614609, 9642094, 9087403, 10500111, 15678420
ChainResidueDetails
NGLY80
NSER35
NSER35
NSER167
NSER167
NLYS66

site_idCSA28
Number of Residues6
Detailsa catalytic site defined by CSA, PubMed 7725097, 7725107, 8684489, 12614609, 9642094, 9087403, 10500111, 15678420
ChainResidueDetails
OGLY80
OSER35
OSER35
OSER167
OSER167
OLYS66

site_idCSA3
Number of Residues6
Detailsa catalytic site defined by CSA, PubMed 7725097, 7725107, 8684489, 12614609, 9642094, 9087403, 10500111, 15678420
ChainResidueDetails
QGLY47
QLYS33
QTHR1
QTHR1
QSER129
QSER129

site_idCSA4
Number of Residues6
Detailsa catalytic site defined by CSA, PubMed 7725097, 7725107, 8684489, 12614609, 9642094, 9087403, 10500111, 15678420
ChainResidueDetails
RGLY47
RLYS33
RTHR1
RTHR1
RSER129
RSER129

site_idCSA5
Number of Residues6
Detailsa catalytic site defined by CSA, PubMed 7725097, 7725107, 8684489, 12614609, 9642094, 9087403, 10500111, 15678420
ChainResidueDetails
SGLY47
SLYS33
STHR1
STHR1
SSER129
SSER129

site_idCSA6
Number of Residues6
Detailsa catalytic site defined by CSA, PubMed 7725097, 7725107, 8684489, 12614609, 9642094, 9087403, 10500111, 15678420
ChainResidueDetails
TGLY47
TLYS33
TTHR1
TTHR1
TSER129
TSER129

site_idCSA7
Number of Residues6
Detailsa catalytic site defined by CSA, PubMed 7725097, 7725107, 8684489, 12614609, 9642094, 9087403, 10500111, 15678420
ChainResidueDetails
UGLY47
ULYS33
UTHR1
UTHR1
USER129
USER129

site_idCSA8
Number of Residues6
Detailsa catalytic site defined by CSA, PubMed 7725097, 7725107, 8684489, 12614609, 9642094, 9087403, 10500111, 15678420
ChainResidueDetails
VGLY47
VLYS33
VTHR1
VTHR1
VSER129
VSER129

site_idCSA9
Number of Residues6
Detailsa catalytic site defined by CSA, PubMed 7725097, 7725107, 8684489, 12614609, 9642094, 9087403, 10500111, 15678420
ChainResidueDetails
WGLY47
WLYS33
WTHR1
WTHR1
WSER129
WSER129

246704

PDB entries from 2025-12-24

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