1PL6

Human SDH/NADH/inhibitor complex

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000721	molecular_function	(R,R)-butanediol dehydrogenase activity
A	0003939	molecular_function	L-iditol 2-dehydrogenase (NAD+) activity
A	0005615	cellular_component	extracellular space
A	0005739	cellular_component	mitochondrion
A	0005829	cellular_component	cytosol
A	0006006	biological_process	glucose metabolic process
A	0006060	biological_process	sorbitol metabolic process
A	0006062	biological_process	sorbitol catabolic process
A	0008270	molecular_function	zinc ion binding
A	0016020	cellular_component	membrane
A	0016491	molecular_function	oxidoreductase activity
A	0016616	molecular_function	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
A	0019640	biological_process	glucuronate catabolic process to xylulose 5-phosphate
A	0030246	molecular_function	carbohydrate binding
A	0030317	biological_process	flagellated sperm motility
A	0031514	cellular_component	motile cilium
A	0031966	cellular_component	mitochondrial membrane
A	0042802	molecular_function	identical protein binding
A	0046370	biological_process	fructose biosynthetic process
A	0046526	molecular_function	D-xylulose reductase activity
A	0046872	molecular_function	metal ion binding
A	0047833	molecular_function	D-sorbitol dehydrogenase (acceptor) activity
A	0050255	molecular_function	ribitol 2-dehydrogenase (NAD+) activity
A	0051160	biological_process	L-xylitol catabolic process
A	0051164	biological_process	L-xylitol metabolic process
A	0051287	molecular_function	NAD binding
A	0070062	cellular_component	extracellular exosome
B	0000721	molecular_function	(R,R)-butanediol dehydrogenase activity
B	0003939	molecular_function	L-iditol 2-dehydrogenase (NAD+) activity
B	0005615	cellular_component	extracellular space
B	0005739	cellular_component	mitochondrion
B	0005829	cellular_component	cytosol
B	0006006	biological_process	glucose metabolic process
B	0006060	biological_process	sorbitol metabolic process
B	0006062	biological_process	sorbitol catabolic process
B	0008270	molecular_function	zinc ion binding
B	0016020	cellular_component	membrane
B	0016491	molecular_function	oxidoreductase activity
B	0016616	molecular_function	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
B	0019640	biological_process	glucuronate catabolic process to xylulose 5-phosphate
B	0030246	molecular_function	carbohydrate binding
B	0030317	biological_process	flagellated sperm motility
B	0031514	cellular_component	motile cilium
B	0031966	cellular_component	mitochondrial membrane
B	0042802	molecular_function	identical protein binding
B	0046370	biological_process	fructose biosynthetic process
B	0046526	molecular_function	D-xylulose reductase activity
B	0046872	molecular_function	metal ion binding
B	0047833	molecular_function	D-sorbitol dehydrogenase (acceptor) activity
B	0050255	molecular_function	ribitol 2-dehydrogenase (NAD+) activity
B	0051160	biological_process	L-xylitol catabolic process
B	0051164	biological_process	L-xylitol metabolic process
B	0051287	molecular_function	NAD binding
B	0070062	cellular_component	extracellular exosome
C	0000721	molecular_function	(R,R)-butanediol dehydrogenase activity
C	0003939	molecular_function	L-iditol 2-dehydrogenase (NAD+) activity
C	0005615	cellular_component	extracellular space
C	0005739	cellular_component	mitochondrion
C	0005829	cellular_component	cytosol
C	0006006	biological_process	glucose metabolic process
C	0006060	biological_process	sorbitol metabolic process
C	0006062	biological_process	sorbitol catabolic process
C	0008270	molecular_function	zinc ion binding
C	0016020	cellular_component	membrane
C	0016491	molecular_function	oxidoreductase activity
C	0016616	molecular_function	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
C	0019640	biological_process	glucuronate catabolic process to xylulose 5-phosphate
C	0030246	molecular_function	carbohydrate binding
C	0030317	biological_process	flagellated sperm motility
C	0031514	cellular_component	motile cilium
C	0031966	cellular_component	mitochondrial membrane
C	0042802	molecular_function	identical protein binding
C	0046370	biological_process	fructose biosynthetic process
C	0046526	molecular_function	D-xylulose reductase activity
C	0046872	molecular_function	metal ion binding
C	0047833	molecular_function	D-sorbitol dehydrogenase (acceptor) activity
C	0050255	molecular_function	ribitol 2-dehydrogenase (NAD+) activity
C	0051160	biological_process	L-xylitol catabolic process
C	0051164	biological_process	L-xylitol metabolic process
C	0051287	molecular_function	NAD binding
C	0070062	cellular_component	extracellular exosome
D	0000721	molecular_function	(R,R)-butanediol dehydrogenase activity
D	0003939	molecular_function	L-iditol 2-dehydrogenase (NAD+) activity
D	0005615	cellular_component	extracellular space
D	0005739	cellular_component	mitochondrion
D	0005829	cellular_component	cytosol
D	0006006	biological_process	glucose metabolic process
D	0006060	biological_process	sorbitol metabolic process
D	0006062	biological_process	sorbitol catabolic process
D	0008270	molecular_function	zinc ion binding
D	0016020	cellular_component	membrane
D	0016491	molecular_function	oxidoreductase activity
D	0016616	molecular_function	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
D	0019640	biological_process	glucuronate catabolic process to xylulose 5-phosphate
D	0030246	molecular_function	carbohydrate binding
D	0030317	biological_process	flagellated sperm motility
D	0031514	cellular_component	motile cilium
D	0031966	cellular_component	mitochondrial membrane
D	0042802	molecular_function	identical protein binding
D	0046370	biological_process	fructose biosynthetic process
D	0046526	molecular_function	D-xylulose reductase activity
D	0046872	molecular_function	metal ion binding
D	0047833	molecular_function	D-sorbitol dehydrogenase (acceptor) activity
D	0050255	molecular_function	ribitol 2-dehydrogenase (NAD+) activity
D	0051160	biological_process	L-xylitol catabolic process
D	0051164	biological_process	L-xylitol metabolic process
D	0051287	molecular_function	NAD binding
D	0070062	cellular_component	extracellular exosome

Functional Information from PDB Data

site_id	AC1
Number of Residues	5
Details	BINDING SITE FOR RESIDUE ZN A 402

Chain	Residue
A	CYS44
A	SER46
A	HIS69
A	572405
A	HOH1064

---

site_id	AC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN B 402

Chain	Residue
B	CYS44
B	HIS69
B	572407
B	HOH1543

---

site_id	AC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN C 402

Chain	Residue
C	CYS44
C	HIS69
C	572409
C	HOH1055

---

site_id	AC4
Number of Residues	5
Details	BINDING SITE FOR RESIDUE ZN D 402

Chain	Residue
D	CYS44
D	SER46
D	HIS69
D	572411
D	HOH1042

---

site_id	AC5
Number of Residues	25
Details	BINDING SITE FOR RESIDUE NAD A 404

Chain	Residue
A	GLY181
A	PRO182
A	ILE183
A	ASP203
A	ARG208
A	CYS249
A	THR250
A	VAL272
A	GLY273
A	LEU274
A	VAL296
A	PHE297
A	ARG298
A	572405
A	HOH1069
A	HOH1330
A	HOH1363
A	HOH1431
A	HOH1501
A	HOH1514
A	HOH1526
A	HOH1579
A	HOH1764
A	HOH2038
A	HOH2205

---

site_id	AC6
Number of Residues	16
Details	BINDING SITE FOR RESIDUE 572 A 405

Chain	Residue
A	CYS44
A	SER46
A	TYR50
A	ILE56
A	PHE59
A	HIS69
A	THR121
A	GLU155
A	LEU274
A	PHE297
A	ZN402
A	NAD404
A	HOH1064
A	HOH1200
A	HOH1645
A	HOH2007

---

site_id	AC7
Number of Residues	26
Details	BINDING SITE FOR RESIDUE NAD B 406

Chain	Residue
B	GLY181
B	PRO182
B	ILE183
B	ASP203
B	LEU204
B	ARG208
B	CYS249
B	THR250
B	VAL272
B	GLY273
B	LEU274
B	VAL296
B	PHE297
B	ARG298
B	572407
B	HOH1034
B	HOH1236
B	HOH1344
B	HOH1358
B	HOH1458
B	HOH1638
B	HOH1666
B	HOH1780
B	HOH1811
B	HOH2061
B	HOH2117

---

site_id	AC8
Number of Residues	15
Details	BINDING SITE FOR RESIDUE 572 B 407

Chain	Residue
B	HOH2005
B	CYS44
B	SER46
B	TYR50
B	ILE56
B	PHE59
B	HIS69
B	THR121
B	GLU155
B	LEU274
B	PHE297
B	ZN402
B	NAD406
B	HOH1490
B	HOH1543

---

site_id	AC9
Number of Residues	25
Details	BINDING SITE FOR RESIDUE NAD C 408

Chain	Residue
C	GLY181
C	PRO182
C	ILE183
C	ASP203
C	LEU204
C	ARG208
C	CYS249
C	THR250
C	VAL272
C	GLY273
C	LEU274
C	VAL296
C	PHE297
C	ARG298
C	572409
C	HOH1174
C	HOH1270
C	HOH1357
C	HOH1420
C	HOH1468
C	HOH1469
C	HOH1681
C	HOH2073
C	HOH2112
C	HOH2187

---

site_id	BC1
Number of Residues	14
Details	BINDING SITE FOR RESIDUE 572 C 409

Chain	Residue
C	CYS44
C	SER46
C	TYR50
C	ILE56
C	PHE59
C	HIS69
C	THR121
C	GLU155
C	LEU274
C	PHE297
C	ZN402
C	NAD408
C	HOH1055
C	HOH1796

---

site_id	BC2
Number of Residues	27
Details	BINDING SITE FOR RESIDUE NAD D 410

Chain	Residue
D	GLY181
D	PRO182
D	ILE183
D	ASP203
D	LEU204
D	ARG208
D	CYS249
D	THR250
D	VAL272
D	GLY273
D	LEU274
D	VAL296
D	PHE297
D	ARG298
D	572411
D	HOH1079
D	HOH1413
D	HOH1447
D	HOH1456
D	HOH1464
D	HOH1484
D	HOH1537
D	HOH1632
D	HOH1737
D	HOH1855
D	HOH1940
D	HOH2208

---

site_id	BC3
Number of Residues	16
Details	BINDING SITE FOR RESIDUE 572 D 411

Chain	Residue
D	CYS44
D	SER46
D	TYR50
D	ILE56
D	PHE59
D	HIS69
D	THR121
D	GLU155
D	LEU274
D	PHE297
D	ZN402
D	NAD410
D	HOH1042
D	HOH1507
D	HOH1976
D	HOH2029

---

Functional Information from PROSITE/UniProt

site_id	PS00059
Number of Residues	15
Details	ADH_ZINC Zinc-containing alcohol dehydrogenases signature. GHEaSGTvekvGssV

Chain	Residue	Details
A	GLY68-VAL82

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	12
Details	BINDING: BINDING => ECO:0000269|PubMed:12962626, ECO:0007744|PDB:1PL7, ECO:0007744|PDB:1PL8

Chain	Residue	Details
A	GLY45
D	GLY45
D	GLU70
D	ALA71
A	GLU70
A	ALA71
B	GLY45
B	GLU70
B	ALA71
C	GLY45
C	GLU70
C	ALA71

---

site_id	SWS_FT_FI2
Number of Residues	16
Details	BINDING: BINDING => ECO:0000250|UniProtKB:P07846

Chain	Residue	Details
A	TRP51
C	PRO156
C	TYR299
C	CYS300
D	TRP51
D	PRO156
D	TYR299
D	CYS300
A	PRO156
A	TYR299
A	CYS300
B	TRP51
B	PRO156
B	TYR299
B	CYS300
C	TRP51

---

site_id	SWS_FT_FI3
Number of Residues	20
Details	BINDING: BINDING => ECO:0000269|PubMed:12962626, ECO:0007744|PDB:1PL6, ECO:0007744|PDB:1PL8

Chain	Residue	Details
A	GLY184
B	PHE297
C	GLY184
C	LEU204
C	LEU209
C	GLY273
C	PHE297
D	GLY184
D	LEU204
D	LEU209
D	GLY273
A	LEU204
D	PHE297
A	LEU209
A	GLY273
A	PHE297
B	GLY184
B	LEU204
B	LEU209
B	GLY273

---

site_id	SWS_FT_FI4
Number of Residues	4
Details	MOD_RES: N-acetylalanine => ECO:0007744|PubMed:19413330, ECO:0007744|PubMed:25944712

Chain	Residue	Details
A	ALA2
B	ALA2
C	ALA2
D	ALA2

---

site_id	SWS_FT_FI5
Number of Residues	8
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:24275569

Chain	Residue	Details
A	LYS211
A	LYS225
B	LYS211
B	LYS225
C	LYS211
C	LYS225
D	LYS211
D	LYS225

---

Catalytic Information from CSA

site_id	CSA1
Number of Residues	2
Details	Annotated By Reference To The Literature 1qlh

Chain	Residue	Details
A	SER46
A	HIS49

---

site_id	CSA2
Number of Residues	2
Details	Annotated By Reference To The Literature 1qlh

Chain	Residue	Details
B	SER46
B	HIS49

---

site_id	CSA3
Number of Residues	2
Details	Annotated By Reference To The Literature 1qlh

Chain	Residue	Details
C	SER46
C	HIS49

---

site_id	CSA4
Number of Residues	2
Details	Annotated By Reference To The Literature 1qlh

Chain	Residue	Details
D	SER46
D	HIS49

---