1PEX

COLLAGENASE-3 (MMP-13) C-TERMINAL HEMOPEXIN-LIKE DOMAIN

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004222	molecular_function	metalloendopeptidase activity
A	0005576	cellular_component	extracellular region
A	0006508	biological_process	proteolysis
A	0030574	biological_process	collagen catabolic process

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 A 500

Chain	Residue
A	ASN326
A	ARG327
A	ARG344
A	ARG346

---

site_id	AC2
Number of Residues	5
Details	BINDING SITE FOR RESIDUE CL A 501

Chain	Residue
A	ILE287
A	ALA331
A	ALA380
A	VAL429
A	CA503

---

site_id	AC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE CA A 502

Chain	Residue
A	ASP285
A	ASP329
A	SER378
A	ASP427

---

site_id	AC4
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA A 503

Chain	Residue
A	ILE287
A	ALA331
A	ALA380
A	VAL429
A	CL501
A	CL504

---

site_id	AC5
Number of Residues	1
Details	BINDING SITE FOR RESIDUE CL A 504

Chain	Residue
A	CA503

---

Functional Information from PROSITE/UniProt

site_id	PS00024
Number of Residues	16
Details	HEMOPEXIN Hemopexin domain signature. TKsfWpelPnRIDAAY

Chain	Residue	Details
A	THR317-TYR332

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	49
Details	Repeat: {"description":"Hemopexin 1"}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	46
Details	Repeat: {"description":"Hemopexin 2"}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	48
Details	Repeat: {"description":"Hemopexin 3"}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	43
Details	Repeat: {"description":"Hemopexin 4"}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	8
Details	Binding site: {"evidences":[{"source":"PubMed","id":"10926524","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"10986126","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15734645","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15780611","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"17196980","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"17623656","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19422229","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"20005097","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"20726512","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"22689580","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"23810497","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"23913860","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"8969305","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	1
Details	Modified residue: {"description":"Phosphotyrosine; by PKDCC","evidences":[{"source":"PubMed","id":"25171405","evidenceCode":"ECO:0000303"}]}

Chain

Residue

Details

---