1PEX

COLLAGENASE-3 (MMP-13) C-TERMINAL HEMOPEXIN-LIKE DOMAIN

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004222	molecular_function	metalloendopeptidase activity
A	0005576	cellular_component	extracellular region
A	0006508	biological_process	proteolysis
A	0030574	biological_process	collagen catabolic process

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 A 500

Chain	Residue
A	ASN326
A	ARG327
A	ARG344
A	ARG346

---

site_id	AC2
Number of Residues	5
Details	BINDING SITE FOR RESIDUE CL A 501

Chain	Residue
A	ILE287
A	ALA331
A	ALA380
A	VAL429
A	CA503

---

site_id	AC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE CA A 502

Chain	Residue
A	ASP285
A	ASP329
A	SER378
A	ASP427

---

site_id	AC4
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA A 503

Chain	Residue
A	ILE287
A	ALA331
A	ALA380
A	VAL429
A	CL501
A	CL504

---

site_id	AC5
Number of Residues	1
Details	BINDING SITE FOR RESIDUE CL A 504

Chain	Residue
A	CA503

---

Functional Information from PROSITE/UniProt

site_id	PS00024
Number of Residues	16
Details	HEMOPEXIN Hemopexin domain signature. TKsfWpelPnRIDAAY

Chain	Residue	Details
A	THR317-TYR332

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	8
Details	BINDING: BINDING => ECO:0000269|PubMed:10926524, ECO:0000269|PubMed:10986126, ECO:0000269|PubMed:15734645, ECO:0000269|PubMed:15780611, ECO:0000269|PubMed:17196980, ECO:0000269|PubMed:17623656, ECO:0000269|PubMed:19422229, ECO:0000269|PubMed:20005097, ECO:0000269|PubMed:20726512, ECO:0000269|PubMed:22689580, ECO:0000269|PubMed:23810497, ECO:0000269|PubMed:23913860, ECO:0000269|PubMed:8969305

Chain	Residue	Details
A	ASP285
A	ILE287
A	ASP329
A	ALA331
A	SER378
A	ALA380
A	ASP427
A	VAL429

---

site_id	SWS_FT_FI2
Number of Residues	1
Details	MOD_RES: Phosphotyrosine; by PKDCC => ECO:0000303|PubMed:25171405

Chain	Residue	Details
A	TYR360

---