1P49
Structure of Human Placental Estrone/DHEA Sulfatase
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004065 | molecular_function | arylsulfatase activity |
| A | 0004773 | molecular_function | steryl-sulfatase activity |
| A | 0005764 | cellular_component | lysosome |
| A | 0005768 | cellular_component | endosome |
| A | 0005783 | cellular_component | endoplasmic reticulum |
| A | 0005788 | cellular_component | endoplasmic reticulum lumen |
| A | 0005789 | cellular_component | endoplasmic reticulum membrane |
| A | 0005794 | cellular_component | Golgi apparatus |
| A | 0005886 | cellular_component | plasma membrane |
| A | 0006706 | biological_process | steroid catabolic process |
| A | 0007565 | biological_process | female pregnancy |
| A | 0008202 | biological_process | steroid metabolic process |
| A | 0008484 | molecular_function | sulfuric ester hydrolase activity |
| A | 0008544 | biological_process | epidermis development |
| A | 0016020 | cellular_component | membrane |
| A | 0016787 | molecular_function | hydrolase activity |
| A | 0031410 | cellular_component | cytoplasmic vesicle |
| A | 0033163 | cellular_component | microneme membrane |
| A | 0043231 | cellular_component | intracellular membrane-bounded organelle |
| A | 0046872 | molecular_function | metal ion binding |
Functional Information from PROSITE/UniProt
| site_id | PS00149 |
| Number of Residues | 11 |
| Details | SULFATASE_2 Sulfatases signature 2. GYsTalIGK.WH |
| Chain | Residue | Details |
| A | GLY126-HIS136 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 510 |
| Details | TOPO_DOM: Lumenal => ECO:0000269|PubMed:2668275 |
| Chain | Residue | Details |
| A | HIS22-ARG184 | |
| A | HIS235-ARG583 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 44 |
| Details | TRANSMEM: Helical => ECO:0000269|PubMed:2668275 |
| Chain | Residue | Details |
| A | LEU185-LEU208 | |
| A | LEU213-LEU234 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 3 |
| Details | TOPO_DOM: Cytoplasmic => ECO:0000269|PubMed:2668275 |
| Chain | Residue | Details |
| A | LEU209-PRO212 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 1 |
| Details | ACT_SITE: Nucleophile => ECO:0000269|PubMed:12657638 |
| Chain | Residue | Details |
| A | ALS75 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 1 |
| Details | ACT_SITE: ACT_SITE => ECO:0000269|PubMed:12657638 |
| Chain | Residue | Details |
| A | HIS136 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 4 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:12657638 |
| Chain | Residue | Details |
| A | ASP35 | |
| A | ASP36 | |
| A | ASP342 | |
| A | GLN343 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 1 |
| Details | BINDING: via 3-oxoalanine => ECO:0000269|PubMed:12657638 |
| Chain | Residue | Details |
| A | ALS75 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 2 |
| Details | SITE: Not glycosylated => ECO:0000269|PubMed:2668275 |
| Chain | Residue | Details |
| A | ASN333 | |
| A | ASN459 |
| site_id | SWS_FT_FI9 |
| Number of Residues | 1 |
| Details | MOD_RES: 3-oxoalanine (Cys) => ECO:0000269|PubMed:12657638 |
| Chain | Residue | Details |
| A | ALS75 |
| site_id | SWS_FT_FI10 |
| Number of Residues | 2 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:12657638, ECO:0000269|PubMed:2668275 |
| Chain | Residue | Details |
| A | ASN47 | |
| A | ASN259 |
