1P3Q

Mechanism of Ubiquitin Recognition by the CUE Domain of VPS9

Functional Information from GO Data

Chain	GOid	namespace	contents
Q	0043130	molecular_function	ubiquitin binding
R	0043130	molecular_function	ubiquitin binding

Functional Information from PROSITE/UniProt

site_id	PS00299
Number of Residues	26
Details	UBIQUITIN_1 Ubiquitin domain signature. KakIqDkegIPpdqQrLIFaGkqleD

Chain	Residue	Details
U	LYS27-ASP52

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	SITE: Interacts with activating enzyme

Chain	Residue	Details
U	ARG54
U	ARG72
V	ARG54
V	ARG72

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site_id	SWS_FT_FI2
Number of Residues	2
Details	SITE: Essential for function

Chain	Residue	Details
U	HIS68
V	HIS68

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site_id	SWS_FT_FI3
Number of Residues	2
Details	MOD_RES: Phosphoserine; by PINK1 => ECO:0000250|UniProtKB:P0CG48

Chain	Residue	Details
U	SER65
V	SER65

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site_id	SWS_FT_FI4
Number of Residues	2
Details	MOD_RES: ADP-ribosylglycine => ECO:0000250|UniProtKB:P0CG48

Chain	Residue	Details
U	GLY76
V	GLY76

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site_id	SWS_FT_FI5
Number of Residues	14
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000250|UniProtKB:P0CG48

Chain	Residue	Details
U	LYS6
V	LYS27
V	LYS29
V	LYS33
V	LYS48
V	LYS63
U	LYS11
U	LYS27
U	LYS29
U	LYS33
U	LYS48
U	LYS63
V	LYS6
V	LYS11

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site_id	SWS_FT_FI6
Number of Residues	4
Details	CROSSLNK: Glycyl lysine isopeptide (Gly-Lys) (interchain with K-? in acceptor proteins) => ECO:0000255|PROSITE-ProRule:PRU00214

Chain	Residue	Details
U	GLY76
V	GLY76

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