Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0006729 | biological_process | tetrahydrobiopterin biosynthetic process |
| A | 0016491 | molecular_function | oxidoreductase activity |
| A | 0031427 | biological_process | response to methotrexate |
| A | 0047040 | molecular_function | pteridine reductase activity |
| B | 0006729 | biological_process | tetrahydrobiopterin biosynthetic process |
| B | 0016491 | molecular_function | oxidoreductase activity |
| B | 0031427 | biological_process | response to methotrexate |
| B | 0047040 | molecular_function | pteridine reductase activity |
| C | 0006729 | biological_process | tetrahydrobiopterin biosynthetic process |
| C | 0016491 | molecular_function | oxidoreductase activity |
| C | 0031427 | biological_process | response to methotrexate |
| C | 0047040 | molecular_function | pteridine reductase activity |
| D | 0006729 | biological_process | tetrahydrobiopterin biosynthetic process |
| D | 0016491 | molecular_function | oxidoreductase activity |
| D | 0031427 | biological_process | response to methotrexate |
| D | 0047040 | molecular_function | pteridine reductase activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 28 |
| Details | BINDING SITE FOR RESIDUE NDP A 300 |
| Chain | Residue |
| A | GLY13 |
| A | SER67 |
| A | ASN109 |
| A | ALA110 |
| A | SER111 |
| A | SER112 |
| A | ASP142 |
| A | MET179 |
| A | VAL180 |
| A | ASP181 |
| A | TYR194 |
| A | ARG17 |
| A | LYS198 |
| A | PRO224 |
| A | GLY225 |
| A | LEU226 |
| A | SER227 |
| A | MTX351 |
| A | HOH400 |
| A | HOH473 |
| A | HOH541 |
| A | LEU18 |
| A | HIS38 |
| A | ARG39 |
| A | SER40 |
| A | ALA64 |
| A | ASP65 |
| A | LEU66 |
| site_id | AC2 |
| Number of Residues | 27 |
| Details | BINDING SITE FOR RESIDUE NDP B 301 |
| Chain | Residue |
| B | GLY13 |
| B | LYS16 |
| B | ARG17 |
| B | LEU18 |
| B | HIS36 |
| B | HIS38 |
| B | ARG39 |
| B | SER40 |
| B | ALA64 |
| B | ASP65 |
| B | LEU66 |
| B | SER67 |
| B | ASN109 |
| B | ALA110 |
| B | SER111 |
| B | SER112 |
| B | ASP142 |
| B | MET179 |
| B | VAL180 |
| B | TYR194 |
| B | LYS198 |
| B | PRO224 |
| B | GLY225 |
| B | SER227 |
| B | VAL228 |
| B | MTX352 |
| B | HOH412 |
| site_id | AC3 |
| Number of Residues | 27 |
| Details | BINDING SITE FOR RESIDUE NDP C 302 |
| Chain | Residue |
| C | GLY13 |
| C | ALA15 |
| C | ARG17 |
| C | LEU18 |
| C | TYR37 |
| C | HIS38 |
| C | ARG39 |
| C | SER40 |
| C | ASP65 |
| C | LEU66 |
| C | SER67 |
| C | ASN109 |
| C | ALA110 |
| C | SER111 |
| C | SER112 |
| C | ASP142 |
| C | SER146 |
| C | MET179 |
| C | VAL180 |
| C | TYR194 |
| C | LYS198 |
| C | PRO224 |
| C | GLY225 |
| C | LEU226 |
| C | SER227 |
| C | VAL228 |
| C | MTX353 |
| site_id | AC4 |
| Number of Residues | 24 |
| Details | BINDING SITE FOR RESIDUE NDP D 303 |
| Chain | Residue |
| D | LYS198 |
| D | PRO224 |
| D | GLY225 |
| D | SER227 |
| D | VAL228 |
| D | MTX354 |
| D | HOH428 |
| D | GLY13 |
| D | ALA15 |
| D | ARG17 |
| D | LEU18 |
| D | HIS38 |
| D | ARG39 |
| D | SER40 |
| D | LEU66 |
| D | SER67 |
| D | ASN109 |
| D | ALA110 |
| D | SER111 |
| D | SER112 |
| D | ASP142 |
| D | MET179 |
| D | VAL180 |
| D | TYR194 |
| site_id | AC5 |
| Number of Residues | 14 |
| Details | BINDING SITE FOR RESIDUE MTX A 351 |
| Chain | Residue |
| A | ARG17 |
| A | SER111 |
| A | PHE113 |
| A | PRO115 |
| A | ASP181 |
| A | LEU188 |
| A | TYR191 |
| A | TYR194 |
| A | LEU226 |
| A | LEU229 |
| A | PRO230 |
| A | TYR241 |
| A | NDP300 |
| A | HOH484 |
| site_id | AC6 |
| Number of Residues | 13 |
| Details | BINDING SITE FOR RESIDUE MTX B 352 |
| Chain | Residue |
| B | ARG17 |
| B | SER111 |
| B | PHE113 |
| B | PRO115 |
| B | ASP181 |
| B | LEU188 |
| B | TYR191 |
| B | TYR194 |
| B | LEU226 |
| B | PRO230 |
| B | MET233 |
| B | TYR241 |
| B | NDP301 |
| site_id | AC7 |
| Number of Residues | 14 |
| Details | BINDING SITE FOR RESIDUE MTX C 353 |
| Chain | Residue |
| C | ARG17 |
| C | SER111 |
| C | PHE113 |
| C | PRO115 |
| C | ASP181 |
| C | LEU188 |
| C | TYR191 |
| C | TYR194 |
| C | LEU226 |
| C | LEU229 |
| C | PRO230 |
| C | MET233 |
| C | TYR241 |
| C | NDP302 |
| site_id | AC8 |
| Number of Residues | 13 |
| Details | BINDING SITE FOR RESIDUE MTX D 354 |
| Chain | Residue |
| D | ARG17 |
| D | SER111 |
| D | PHE113 |
| D | PRO115 |
| D | ASP181 |
| D | TYR191 |
| D | TYR194 |
| D | LEU229 |
| D | PRO230 |
| D | MET233 |
| D | TYR241 |
| D | NDP303 |
| D | HOH509 |
Functional Information from PROSITE/UniProt
| site_id | PS00061 |
| Number of Residues | 29 |
| Details | ADH_SHORT Short-chain dehydrogenases/reductases family signature. DamtsqpllgYtmYTMAKEALeGLTrSAA |
| Chain | Residue | Details |
| A | ASP181-ALA209 | |
Functional Information from SwissProt/UniProt
| Chain | Residue | Details |
| A | TYR194 | |
| B | TYR194 | |
| C | TYR194 | |
| D | TYR194 | |
| Chain | Residue | Details |
| C | GLY13 | |
| C | TYR194 | |
| D | GLY13 | |
| D | TYR194 | |
| A | GLY13 | |
| A | TYR194 | |
| B | GLY13 | |
| B | TYR194 | |
| site_id | SWS_FT_FI3 |
| Number of Residues | 4 |
| Details | BINDING: BINDING => ECO:0000250 |
| Chain | Residue | Details |
| A | SER175 | |
| B | SER175 | |
| C | SER175 | |
| D | SER175 | |
