Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0006729 | biological_process | tetrahydrobiopterin biosynthetic process |
A | 0016491 | molecular_function | oxidoreductase activity |
A | 0031427 | biological_process | response to methotrexate |
A | 0047040 | molecular_function | pteridine reductase activity |
B | 0006729 | biological_process | tetrahydrobiopterin biosynthetic process |
B | 0016491 | molecular_function | oxidoreductase activity |
B | 0031427 | biological_process | response to methotrexate |
B | 0047040 | molecular_function | pteridine reductase activity |
C | 0006729 | biological_process | tetrahydrobiopterin biosynthetic process |
C | 0016491 | molecular_function | oxidoreductase activity |
C | 0031427 | biological_process | response to methotrexate |
C | 0047040 | molecular_function | pteridine reductase activity |
D | 0006729 | biological_process | tetrahydrobiopterin biosynthetic process |
D | 0016491 | molecular_function | oxidoreductase activity |
D | 0031427 | biological_process | response to methotrexate |
D | 0047040 | molecular_function | pteridine reductase activity |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 28 |
Details | BINDING SITE FOR RESIDUE NDP A 300 |
Chain | Residue |
A | GLY13 |
A | SER67 |
A | ASN109 |
A | ALA110 |
A | SER111 |
A | SER112 |
A | ASP142 |
A | MET179 |
A | VAL180 |
A | ASP181 |
A | TYR194 |
A | ARG17 |
A | LYS198 |
A | PRO224 |
A | GLY225 |
A | LEU226 |
A | SER227 |
A | MTX351 |
A | HOH400 |
A | HOH473 |
A | HOH541 |
A | LEU18 |
A | HIS38 |
A | ARG39 |
A | SER40 |
A | ALA64 |
A | ASP65 |
A | LEU66 |
site_id | AC2 |
Number of Residues | 27 |
Details | BINDING SITE FOR RESIDUE NDP B 301 |
Chain | Residue |
B | GLY13 |
B | LYS16 |
B | ARG17 |
B | LEU18 |
B | HIS36 |
B | HIS38 |
B | ARG39 |
B | SER40 |
B | ALA64 |
B | ASP65 |
B | LEU66 |
B | SER67 |
B | ASN109 |
B | ALA110 |
B | SER111 |
B | SER112 |
B | ASP142 |
B | MET179 |
B | VAL180 |
B | TYR194 |
B | LYS198 |
B | PRO224 |
B | GLY225 |
B | SER227 |
B | VAL228 |
B | MTX352 |
B | HOH412 |
site_id | AC3 |
Number of Residues | 27 |
Details | BINDING SITE FOR RESIDUE NDP C 302 |
Chain | Residue |
C | GLY13 |
C | ALA15 |
C | ARG17 |
C | LEU18 |
C | TYR37 |
C | HIS38 |
C | ARG39 |
C | SER40 |
C | ASP65 |
C | LEU66 |
C | SER67 |
C | ASN109 |
C | ALA110 |
C | SER111 |
C | SER112 |
C | ASP142 |
C | SER146 |
C | MET179 |
C | VAL180 |
C | TYR194 |
C | LYS198 |
C | PRO224 |
C | GLY225 |
C | LEU226 |
C | SER227 |
C | VAL228 |
C | MTX353 |
site_id | AC4 |
Number of Residues | 24 |
Details | BINDING SITE FOR RESIDUE NDP D 303 |
Chain | Residue |
D | LYS198 |
D | PRO224 |
D | GLY225 |
D | SER227 |
D | VAL228 |
D | MTX354 |
D | HOH428 |
D | GLY13 |
D | ALA15 |
D | ARG17 |
D | LEU18 |
D | HIS38 |
D | ARG39 |
D | SER40 |
D | LEU66 |
D | SER67 |
D | ASN109 |
D | ALA110 |
D | SER111 |
D | SER112 |
D | ASP142 |
D | MET179 |
D | VAL180 |
D | TYR194 |
site_id | AC5 |
Number of Residues | 14 |
Details | BINDING SITE FOR RESIDUE MTX A 351 |
Chain | Residue |
A | ARG17 |
A | SER111 |
A | PHE113 |
A | PRO115 |
A | ASP181 |
A | LEU188 |
A | TYR191 |
A | TYR194 |
A | LEU226 |
A | LEU229 |
A | PRO230 |
A | TYR241 |
A | NDP300 |
A | HOH484 |
site_id | AC6 |
Number of Residues | 13 |
Details | BINDING SITE FOR RESIDUE MTX B 352 |
Chain | Residue |
B | ARG17 |
B | SER111 |
B | PHE113 |
B | PRO115 |
B | ASP181 |
B | LEU188 |
B | TYR191 |
B | TYR194 |
B | LEU226 |
B | PRO230 |
B | MET233 |
B | TYR241 |
B | NDP301 |
site_id | AC7 |
Number of Residues | 14 |
Details | BINDING SITE FOR RESIDUE MTX C 353 |
Chain | Residue |
C | ARG17 |
C | SER111 |
C | PHE113 |
C | PRO115 |
C | ASP181 |
C | LEU188 |
C | TYR191 |
C | TYR194 |
C | LEU226 |
C | LEU229 |
C | PRO230 |
C | MET233 |
C | TYR241 |
C | NDP302 |
site_id | AC8 |
Number of Residues | 13 |
Details | BINDING SITE FOR RESIDUE MTX D 354 |
Chain | Residue |
D | ARG17 |
D | SER111 |
D | PHE113 |
D | PRO115 |
D | ASP181 |
D | TYR191 |
D | TYR194 |
D | LEU229 |
D | PRO230 |
D | MET233 |
D | TYR241 |
D | NDP303 |
D | HOH509 |
Functional Information from PROSITE/UniProt
site_id | PS00061 |
Number of Residues | 29 |
Details | ADH_SHORT Short-chain dehydrogenases/reductases family signature. DamtsqpllgYtmYTMAKEALeGLTrSAA |
Chain | Residue | Details |
A | ASP181-ALA209 | |
Functional Information from SwissProt/UniProt
Chain | Residue | Details |
A | TYR194 | |
B | TYR194 | |
C | TYR194 | |
D | TYR194 | |
Chain | Residue | Details |
A | GLY13 | |
A | TYR194 | |
B | GLY13 | |
B | TYR194 | |
C | GLY13 | |
C | TYR194 | |
D | GLY13 | |
D | TYR194 | |
site_id | SWS_FT_FI3 |
Number of Residues | 4 |
Details | BINDING: BINDING => ECO:0000250 |
Chain | Residue | Details |
A | SER175 | |
B | SER175 | |
C | SER175 | |
D | SER175 | |
Catalytic Information from CSA
site_id | CSA1 |
Number of Residues | 3 |
Details | Annotated By Reference To The Literature 1eq2 |
Chain | Residue | Details |
A | THR172 | |
A | LYS198 | |
A | TYR194 | |
site_id | CSA10 |
Number of Residues | 2 |
Details | Annotated By Reference To The Literature 1eq2 |
Chain | Residue | Details |
B | LYS198 | |
B | TYR194 | |
site_id | CSA11 |
Number of Residues | 2 |
Details | Annotated By Reference To The Literature 1eq2 |
Chain | Residue | Details |
C | LYS198 | |
C | TYR194 | |
site_id | CSA12 |
Number of Residues | 2 |
Details | Annotated By Reference To The Literature 1eq2 |
Chain | Residue | Details |
D | LYS198 | |
D | TYR194 | |
site_id | CSA2 |
Number of Residues | 3 |
Details | Annotated By Reference To The Literature 1eq2 |
Chain | Residue | Details |
B | THR172 | |
B | LYS198 | |
B | TYR194 | |
site_id | CSA3 |
Number of Residues | 3 |
Details | Annotated By Reference To The Literature 1eq2 |
Chain | Residue | Details |
C | THR172 | |
C | LYS198 | |
C | TYR194 | |
site_id | CSA4 |
Number of Residues | 3 |
Details | Annotated By Reference To The Literature 1eq2 |
Chain | Residue | Details |
D | THR172 | |
D | LYS198 | |
D | TYR194 | |
site_id | CSA5 |
Number of Residues | 2 |
Details | Annotated By Reference To The Literature 1eq2 |
Chain | Residue | Details |
A | LYS198 | |
A | TYR191 | |
site_id | CSA6 |
Number of Residues | 2 |
Details | Annotated By Reference To The Literature 1eq2 |
Chain | Residue | Details |
B | LYS198 | |
B | TYR191 | |
site_id | CSA7 |
Number of Residues | 2 |
Details | Annotated By Reference To The Literature 1eq2 |
Chain | Residue | Details |
C | LYS198 | |
C | TYR191 | |
site_id | CSA8 |
Number of Residues | 2 |
Details | Annotated By Reference To The Literature 1eq2 |
Chain | Residue | Details |
D | LYS198 | |
D | TYR191 | |
site_id | CSA9 |
Number of Residues | 2 |
Details | Annotated By Reference To The Literature 1eq2 |
Chain | Residue | Details |
A | LYS198 | |
A | TYR194 | |