1OTX
Purine Nucleoside Phosphorylase M64V mutant
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0003824 | molecular_function | catalytic activity |
A | 0004731 | molecular_function | purine-nucleoside phosphorylase activity |
A | 0005829 | cellular_component | cytosol |
A | 0006139 | biological_process | nucleobase-containing compound metabolic process |
A | 0006152 | biological_process | purine nucleoside catabolic process |
A | 0006974 | biological_process | DNA damage response |
A | 0009116 | biological_process | nucleoside metabolic process |
A | 0009164 | biological_process | nucleoside catabolic process |
A | 0016020 | cellular_component | membrane |
A | 0016740 | molecular_function | transferase activity |
A | 0016757 | molecular_function | glycosyltransferase activity |
A | 0016763 | molecular_function | pentosyltransferase activity |
A | 0019686 | biological_process | purine nucleoside interconversion |
A | 0042278 | biological_process | purine nucleoside metabolic process |
A | 0042802 | molecular_function | identical protein binding |
A | 0047975 | molecular_function | guanosine phosphorylase activity |
B | 0003824 | molecular_function | catalytic activity |
B | 0004731 | molecular_function | purine-nucleoside phosphorylase activity |
B | 0005829 | cellular_component | cytosol |
B | 0006139 | biological_process | nucleobase-containing compound metabolic process |
B | 0006152 | biological_process | purine nucleoside catabolic process |
B | 0006974 | biological_process | DNA damage response |
B | 0009116 | biological_process | nucleoside metabolic process |
B | 0009164 | biological_process | nucleoside catabolic process |
B | 0016020 | cellular_component | membrane |
B | 0016740 | molecular_function | transferase activity |
B | 0016757 | molecular_function | glycosyltransferase activity |
B | 0016763 | molecular_function | pentosyltransferase activity |
B | 0019686 | biological_process | purine nucleoside interconversion |
B | 0042278 | biological_process | purine nucleoside metabolic process |
B | 0042802 | molecular_function | identical protein binding |
B | 0047975 | molecular_function | guanosine phosphorylase activity |
C | 0003824 | molecular_function | catalytic activity |
C | 0004731 | molecular_function | purine-nucleoside phosphorylase activity |
C | 0005829 | cellular_component | cytosol |
C | 0006139 | biological_process | nucleobase-containing compound metabolic process |
C | 0006152 | biological_process | purine nucleoside catabolic process |
C | 0006974 | biological_process | DNA damage response |
C | 0009116 | biological_process | nucleoside metabolic process |
C | 0009164 | biological_process | nucleoside catabolic process |
C | 0016020 | cellular_component | membrane |
C | 0016740 | molecular_function | transferase activity |
C | 0016757 | molecular_function | glycosyltransferase activity |
C | 0016763 | molecular_function | pentosyltransferase activity |
C | 0019686 | biological_process | purine nucleoside interconversion |
C | 0042278 | biological_process | purine nucleoside metabolic process |
C | 0042802 | molecular_function | identical protein binding |
C | 0047975 | molecular_function | guanosine phosphorylase activity |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 7 |
Details | BINDING SITE FOR RESIDUE PO4 A 247 |
Chain | Residue |
A | GLY20 |
A | ARG24 |
A | ARG43 |
A | ARG87 |
A | GLY89 |
A | SER90 |
A | HOH288 |
site_id | AC2 |
Number of Residues | 7 |
Details | BINDING SITE FOR RESIDUE PO4 B 248 |
Chain | Residue |
B | GLY89 |
B | SER90 |
B | HOH251 |
B | HOH274 |
C | ARG43 |
B | GLY20 |
B | ARG87 |
site_id | AC3 |
Number of Residues | 7 |
Details | BINDING SITE FOR RESIDUE PO4 C 249 |
Chain | Residue |
B | ARG43 |
C | PRO19 |
C | GLY20 |
C | ARG87 |
C | GLY89 |
C | SER90 |
C | HOH274 |
Functional Information from PROSITE/UniProt
site_id | PS01232 |
Number of Residues | 16 |
Details | PNP_UDP_1 Purine and other phosphorylases family 1 signature. GhGVGiPScSIytkEL |
Chain | Residue | Details |
A | GLY61-LEU76 |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 3 |
Details | ACT_SITE: Proton donor => ECO:0000255|HAMAP-Rule:MF_01627, ECO:0000269|PubMed:30337572 |
Chain | Residue | Details |
A | HIS205 | |
B | HIS205 | |
C | HIS205 |
site_id | SWS_FT_FI2 |
Number of Residues | 3 |
Details | BINDING: BINDING => ECO:0000305|PubMed:30337572, ECO:0007744|PDB:4TS3, ECO:0007744|PDB:4TS9, ECO:0007744|PDB:4TTA, ECO:0007744|PDB:4TTI, ECO:0007744|PDB:4TTJ |
Chain | Residue | Details |
A | ILE5 | |
B | ILE5 | |
C | ILE5 |
site_id | SWS_FT_FI3 |
Number of Residues | 9 |
Details | BINDING: in other chain => ECO:0000269|PubMed:11786017, ECO:0000269|PubMed:21672603, ECO:0000269|PubMed:30337572, ECO:0007744|PDB:1K9S, ECO:0007744|PDB:3ONV, ECO:0007744|PDB:3OOE, ECO:0007744|PDB:3OOH, ECO:0007744|PDB:3OPV, ECO:0007744|PDB:4TS3, ECO:0007744|PDB:4TS9, ECO:0007744|PDB:4TTA, ECO:0007744|PDB:4TTI, ECO:0007744|PDB:4TTJ |
Chain | Residue | Details |
A | ASP21 | |
A | ALA25 | |
A | VAL88 | |
B | ASP21 | |
B | ALA25 | |
B | VAL88 | |
C | ASP21 | |
C | ALA25 | |
C | VAL88 |
site_id | SWS_FT_FI4 |
Number of Residues | 3 |
Details | BINDING: BINDING => ECO:0000269|PubMed:11786017, ECO:0000269|PubMed:21672603, ECO:0000269|PubMed:30337572, ECO:0007744|PDB:1K9S, ECO:0007744|PDB:3ONV, ECO:0007744|PDB:3OOE, ECO:0007744|PDB:3OOH, ECO:0007744|PDB:3OPV, ECO:0007744|PDB:4TS3, ECO:0007744|PDB:4TS9, ECO:0007744|PDB:4TTA, ECO:0007744|PDB:4TTI, ECO:0007744|PDB:4TTJ |
Chain | Residue | Details |
A | GLY44 | |
B | GLY44 | |
C | GLY44 |
site_id | SWS_FT_FI5 |
Number of Residues | 6 |
Details | BINDING: in other chain => ECO:0000305|PubMed:30337572, ECO:0007744|PDB:4TS3, ECO:0007744|PDB:4TS9, ECO:0007744|PDB:4TTA, ECO:0007744|PDB:4TTI, ECO:0007744|PDB:4TTJ |
Chain | Residue | Details |
A | MET180 | |
A | ASP204 | |
B | MET180 | |
B | ASP204 | |
C | MET180 | |
C | ASP204 |
site_id | SWS_FT_FI6 |
Number of Residues | 3 |
Details | SITE: Important for catalytic activity => ECO:0000255|HAMAP-Rule:MF_01627, ECO:0000269|PubMed:21672603, ECO:0000269|PubMed:30337572 |
Chain | Residue | Details |
A | GLN218 | |
B | GLN218 | |
C | GLN218 |
site_id | SWS_FT_FI7 |
Number of Residues | 3 |
Details | MOD_RES: N6-acetyllysine => ECO:0000269|PubMed:18723842 |
Chain | Residue | Details |
A | TYR27 | |
B | TYR27 | |
C | TYR27 |
Catalytic Information from CSA
site_id | MCSA1 |
Number of Residues | 7 |
Details | M-CSA 375 |
Chain | Residue | Details |
A | ASP21 | electrostatic stabiliser |
A | ALA25 | electrostatic stabiliser |
A | GLY44 | electrostatic stabiliser |
A | VAL88 | electrostatic stabiliser |
A | CYS91 | electrostatic stabiliser |
A | HIS205 | proton shuttle (general acid/base) |
A | GLN218 | enhance reactivity |
site_id | MCSA2 |
Number of Residues | 7 |
Details | M-CSA 375 |
Chain | Residue | Details |
B | ASP21 | electrostatic stabiliser |
B | ALA25 | electrostatic stabiliser |
B | GLY44 | electrostatic stabiliser |
B | VAL88 | electrostatic stabiliser |
B | CYS91 | electrostatic stabiliser |
B | HIS205 | proton shuttle (general acid/base) |
B | GLN218 | enhance reactivity |
site_id | MCSA3 |
Number of Residues | 7 |
Details | M-CSA 375 |
Chain | Residue | Details |
C | ASP21 | electrostatic stabiliser |
C | ALA25 | electrostatic stabiliser |
C | GLY44 | electrostatic stabiliser |
C | VAL88 | electrostatic stabiliser |
C | CYS91 | electrostatic stabiliser |
C | HIS205 | proton shuttle (general acid/base) |
C | GLN218 | enhance reactivity |