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Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

1OKC

structure of mitochondrial ADP/ATP carrier in complex with carboxyatractyloside

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005471	molecular_function	ATP:ADP antiporter activity
A	0005739	cellular_component	mitochondrion
A	0005743	cellular_component	mitochondrial inner membrane
A	0005757	cellular_component	mitochondrial permeability transition pore complex
A	0015297	molecular_function	antiporter activity
A	0015866	biological_process	ADP transport
A	0017077	molecular_function	oxidative phosphorylation uncoupler activity
A	0031966	cellular_component	mitochondrial membrane
A	0046902	biological_process	regulation of mitochondrial membrane permeability
A	0055085	biological_process	transmembrane transport
A	0140021	biological_process	mitochondrial ADP transmembrane transport
A	1901029	biological_process	negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway
A	1901526	biological_process	positive regulation of mitophagy
A	1902600	biological_process	proton transmembrane transport
A	1990544	biological_process	mitochondrial ATP transmembrane transport
A	1990845	biological_process	adaptive thermogenesis

Functional Information from PDB Data

site_id	AC1
Number of Residues	18
Details	BINDING SITE FOR RESIDUE CXT A 401

Chain	Residue
A	ARG79
A	PHE230
A	ASP231
A	ARG234
A	HOH2004
A	HOH2038
A	HOH2076
A	HOH2077
A	HOH2078
A	HOH2079
A	ASN87
A	LYS91
A	GLY123
A	LEU127
A	GLY182
A	ILE183
A	ARG187
A	SER227

site_id	AC2
Number of Residues	10
Details	BINDING SITE FOR RESIDUE CDL A 800

Chain	Residue
A	TRP70
A	ARG71
A	GLY72
A	ASN73
A	LEU74
A	TRP109
A	LEU140
A	PC1980
A	HOH2024
A	HOH2080

site_id	AC3
Number of Residues	9
Details	BINDING SITE FOR RESIDUE CDL A 801

Chain	Residue
A	ILE53
A	ILE54
A	PHE270
A	GLY272
A	ALA273
A	TRP274
A	SER275
A	PC1983
A	HOH2083

site_id	AC4
Number of Residues	5
Details	BINDING SITE FOR RESIDUE CDL A 802

Chain	Residue
A	CYS128
A	PHE176
A	ASN177
A	GLN181
A	LEU289

site_id	AC5
Number of Residues	4
Details	BINDING SITE FOR RESIDUE LDM A 903

Chain	Residue
A	PRO266
A	PHE269
A	PHE270
A	LDM904

site_id	AC6
Number of Residues	5
Details	BINDING SITE FOR RESIDUE LDM A 904

Chain	Residue
A	VAL226
A	PRO229
A	PHE230
A	TRP257
A	LDM903

site_id	AC7
Number of Residues	12
Details	BINDING SITE FOR RESIDUE PC1 A 980

Chain	Residue
A	LEU74
A	PHE108
A	TRP109
A	THR154
A	GLY155
A	LEU156
A	GLY157
A	ASN158
A	GLY192
A	ASP195
A	THR196
A	CDL800

site_id	AC8
Number of Residues	8
Details	BINDING SITE FOR RESIDUE PC1 A 981

Chain	Residue
A	LYS106
A	GLN107
A	PHE108
A	TRP109
A	ARG110
A	ALA113
A	PC1982
A	PC1982

site_id	AC9
Number of Residues	7
Details	BINDING SITE FOR RESIDUE PC1 A 982

Chain	Residue
A	PHE66
A	LEU67
A	ARG110
A	ALA113
A	PC1981
A	PC1981
A	HOH2082

site_id	BC1
Number of Residues	2
Details	BINDING SITE FOR RESIDUE PC1 A 983

Chain	Residue
A	CDL801
A	HOH2083

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	25
Details	TOPO_DOM: Mitochondrial intermembrane => ECO:0000305

Chain	Residue	Details
A	SER1-PHE7
A	GLY100-TRP109
A	MET200-ILE210

site_id	SWS_FT_FI2
Number of Residues	29
Details	TRANSMEM: Helical; Name=1 => ECO:0000269\|PubMed:14603310, ECO:0000269\|PubMed:16226253

Chain	Residue	Details
A	LEU8-VAL37

site_id	SWS_FT_FI3
Number of Residues	124
Details	TOPO_DOM: Mitochondrial matrix => ECO:0000305

Chain	Residue	Details
A	GLN38-LEU74
A	TYR131-VAL178
A	THR232-ALA273

site_id	SWS_FT_FI4
Number of Residues	24
Details	TRANSMEM: Helical; Name=2 => ECO:0000269\|PubMed:14603310, ECO:0000269\|PubMed:16226253

Chain	Residue	Details
A	ALA75-LEU99

site_id	SWS_FT_FI5
Number of Residues	20
Details	TRANSMEM: Helical; Name=3 => ECO:0000269\|PubMed:14603310, ECO:0000269\|PubMed:16226253

Chain	Residue	Details
A	ARG110-VAL130

site_id	SWS_FT_FI6
Number of Residues	20
Details	TRANSMEM: Helical; Name=4 => ECO:0000269\|PubMed:14603310, ECO:0000269\|PubMed:16226253

Chain	Residue	Details
A	SER179-GLY199

site_id	SWS_FT_FI7
Number of Residues	20
Details	TRANSMEM: Helical; Name=5 => ECO:0000269\|PubMed:14603310, ECO:0000269\|PubMed:16226253

Chain	Residue	Details
A	VAL211-ASP231

site_id	SWS_FT_FI8
Number of Residues	17
Details	TRANSMEM: Helical; Name=6 => ECO:0000269\|PubMed:14603310, ECO:0000269\|PubMed:16226253

Chain	Residue	Details
A	TRP274-ASP291

site_id	SWS_FT_FI9
Number of Residues	3
Details	BINDING: BINDING => ECO:0000305\|PubMed:14603310

Chain	Residue	Details
A	TYR80
A	ASP92
A	ARG235

site_id	SWS_FT_FI10
Number of Residues	1
Details	MOD_RES: N-acetylserine => ECO:0000269\|PubMed:7076130

Chain	Residue	Details
A	ASP2

site_id	SWS_FT_FI11
Number of Residues	1
Details	MOD_RES: Phosphoserine => ECO:0000250\|UniProtKB:Q05962

Chain	Residue	Details
A	PHE7

site_id	SWS_FT_FI12
Number of Residues	1
Details	MOD_RES: N6-methyllysine => ECO:0000255

Chain	Residue	Details
A	GLY52

site_id	SWS_FT_FI13
Number of Residues	3
Details	MOD_RES: N6-succinyllysine => ECO:0000250\|UniProtKB:P48962

Chain	Residue	Details
A	GLY147
A	GLY245
A	GLY272

site_id	SWS_FT_FI14
Number of Residues	1
Details	MOD_RES: S-nitrosocysteine => ECO:0000250\|UniProtKB:Q05962

Chain	Residue	Details
A	ILE160

222036

PDB entries from 2024-07-03

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