1OIP
The Molecular Basis of Vitamin E Retention: Structure of Human Alpha-Tocopherol Transfer Protein
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0001890 | biological_process | placenta development |
| A | 0001892 | biological_process | embryonic placenta development |
| A | 0005515 | molecular_function | protein binding |
| A | 0005546 | molecular_function | phosphatidylinositol-4,5-bisphosphate binding |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005770 | cellular_component | late endosome |
| A | 0005829 | cellular_component | cytosol |
| A | 0006629 | biological_process | lipid metabolic process |
| A | 0008289 | molecular_function | lipid binding |
| A | 0008431 | molecular_function | vitamin E binding |
| A | 0009636 | biological_process | response to toxic substance |
| A | 0042360 | biological_process | vitamin E metabolic process |
| A | 0043325 | molecular_function | phosphatidylinositol-3,4-bisphosphate binding |
| A | 0051180 | biological_process | vitamin transport |
| A | 0090212 | biological_process | negative regulation of establishment of blood-brain barrier |
| A | 0120009 | biological_process | intermembrane lipid transfer |
| A | 0120013 | molecular_function | lipid transfer activity |
| A | 1900223 | biological_process | positive regulation of amyloid-beta clearance |
| A | 1902936 | molecular_function | phosphatidylinositol bisphosphate binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE SO4 A1276 |
| Chain | Residue |
| A | LYS190 |
| A | ARG192 |
| A | LYS217 |
| A | ARG221 |
| A | HOH2124 |
| site_id | AC2 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE SO4 A1277 |
| Chain | Residue |
| A | HIS223 |
| A | HIS225 |
| A | SER232 |
| A | HIS236 |
| site_id | AC3 |
| Number of Residues | 10 |
| Details | BINDING SITE FOR RESIDUE VIV A1278 |
| Chain | Residue |
| A | SER136 |
| A | SER140 |
| A | ILE154 |
| A | PHE158 |
| A | VAL182 |
| A | LEU183 |
| A | PHE187 |
| A | VAL191 |
| A | HOH2050 |
| A | HOH2125 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 165 |
| Details | Domain: {"description":"CRAL-TRIO","evidences":[{"source":"PROSITE-ProRule","id":"PRU00056","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 9 |
| Details | Binding site: {"evidences":[{"source":"UniProtKB","id":"Q8BWP5","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
