1OF6
crystal structure of the tyrosine-regulated 3-deoxy-d-arabino-heptulosonate-7-phosphate synthase from saccharomyces cerevisiae complexed with tyrosine and manganese
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0003849 | molecular_function | 3-deoxy-7-phosphoheptulonate synthase activity |
A | 0005634 | cellular_component | nucleus |
A | 0005737 | cellular_component | cytoplasm |
A | 0008652 | biological_process | amino acid biosynthetic process |
A | 0009058 | biological_process | biosynthetic process |
A | 0009073 | biological_process | aromatic amino acid family biosynthetic process |
A | 0009423 | biological_process | chorismate biosynthetic process |
A | 0016740 | molecular_function | transferase activity |
B | 0003849 | molecular_function | 3-deoxy-7-phosphoheptulonate synthase activity |
B | 0005634 | cellular_component | nucleus |
B | 0005737 | cellular_component | cytoplasm |
B | 0008652 | biological_process | amino acid biosynthetic process |
B | 0009058 | biological_process | biosynthetic process |
B | 0009073 | biological_process | aromatic amino acid family biosynthetic process |
B | 0009423 | biological_process | chorismate biosynthetic process |
B | 0016740 | molecular_function | transferase activity |
C | 0003849 | molecular_function | 3-deoxy-7-phosphoheptulonate synthase activity |
C | 0005634 | cellular_component | nucleus |
C | 0005737 | cellular_component | cytoplasm |
C | 0008652 | biological_process | amino acid biosynthetic process |
C | 0009058 | biological_process | biosynthetic process |
C | 0009073 | biological_process | aromatic amino acid family biosynthetic process |
C | 0009423 | biological_process | chorismate biosynthetic process |
C | 0016740 | molecular_function | transferase activity |
D | 0003849 | molecular_function | 3-deoxy-7-phosphoheptulonate synthase activity |
D | 0005634 | cellular_component | nucleus |
D | 0005737 | cellular_component | cytoplasm |
D | 0008652 | biological_process | amino acid biosynthetic process |
D | 0009058 | biological_process | biosynthetic process |
D | 0009073 | biological_process | aromatic amino acid family biosynthetic process |
D | 0009423 | biological_process | chorismate biosynthetic process |
D | 0016740 | molecular_function | transferase activity |
E | 0003849 | molecular_function | 3-deoxy-7-phosphoheptulonate synthase activity |
E | 0005634 | cellular_component | nucleus |
E | 0005737 | cellular_component | cytoplasm |
E | 0008652 | biological_process | amino acid biosynthetic process |
E | 0009058 | biological_process | biosynthetic process |
E | 0009073 | biological_process | aromatic amino acid family biosynthetic process |
E | 0009423 | biological_process | chorismate biosynthetic process |
E | 0016740 | molecular_function | transferase activity |
F | 0003849 | molecular_function | 3-deoxy-7-phosphoheptulonate synthase activity |
F | 0005634 | cellular_component | nucleus |
F | 0005737 | cellular_component | cytoplasm |
F | 0008652 | biological_process | amino acid biosynthetic process |
F | 0009058 | biological_process | biosynthetic process |
F | 0009073 | biological_process | aromatic amino acid family biosynthetic process |
F | 0009423 | biological_process | chorismate biosynthetic process |
F | 0016740 | molecular_function | transferase activity |
G | 0003849 | molecular_function | 3-deoxy-7-phosphoheptulonate synthase activity |
G | 0005634 | cellular_component | nucleus |
G | 0005737 | cellular_component | cytoplasm |
G | 0008652 | biological_process | amino acid biosynthetic process |
G | 0009058 | biological_process | biosynthetic process |
G | 0009073 | biological_process | aromatic amino acid family biosynthetic process |
G | 0009423 | biological_process | chorismate biosynthetic process |
G | 0016740 | molecular_function | transferase activity |
H | 0003849 | molecular_function | 3-deoxy-7-phosphoheptulonate synthase activity |
H | 0005634 | cellular_component | nucleus |
H | 0005737 | cellular_component | cytoplasm |
H | 0008652 | biological_process | amino acid biosynthetic process |
H | 0009058 | biological_process | biosynthetic process |
H | 0009073 | biological_process | aromatic amino acid family biosynthetic process |
H | 0009423 | biological_process | chorismate biosynthetic process |
H | 0016740 | molecular_function | transferase activity |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE MN A 1369 |
Chain | Residue |
A | CYS76 |
A | HIS282 |
A | GLU316 |
A | ASP342 |
site_id | AC2 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE MN B 1369 |
Chain | Residue |
B | CYS76 |
B | HIS282 |
B | GLU316 |
B | ASP342 |
B | HOH2091 |
site_id | AC3 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE MN C 1370 |
Chain | Residue |
C | CYS76 |
C | HIS282 |
C | GLU316 |
C | ASP342 |
site_id | AC4 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE MN D 1369 |
Chain | Residue |
D | CYS76 |
D | HIS282 |
D | GLU316 |
D | ASP342 |
site_id | AC5 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE MN E 1369 |
Chain | Residue |
E | CYS76 |
E | HIS282 |
E | GLU316 |
E | ASP342 |
site_id | AC6 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE MN F 1369 |
Chain | Residue |
F | CYS76 |
F | HIS282 |
F | GLU316 |
F | ASP342 |
F | HOH2088 |
site_id | AC7 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE MN G 1368 |
Chain | Residue |
G | CYS76 |
G | HIS282 |
G | GLU316 |
G | ASP342 |
site_id | AC8 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE MN H 1368 |
Chain | Residue |
H | CYS76 |
H | HIS282 |
H | GLU316 |
H | ASP342 |
site_id | AC9 |
Number of Residues | 11 |
Details | BINDING SITE FOR RESIDUE DTY A 1370 |
Chain | Residue |
A | THR162 |
A | GLN166 |
A | ALA169 |
A | GLY193 |
A | LEU194 |
A | SER195 |
A | GLY226 |
A | VAL227 |
B | GLU21 |
B | ASP22 |
B | TYR28 |
site_id | BC1 |
Number of Residues | 12 |
Details | BINDING SITE FOR RESIDUE DTY B 1370 |
Chain | Residue |
A | GLU21 |
A | ASP22 |
A | ILE25 |
A | TYR28 |
B | THR162 |
B | GLN166 |
B | ALA169 |
B | GLY193 |
B | LEU194 |
B | SER195 |
B | GLY226 |
B | VAL227 |
site_id | BC2 |
Number of Residues | 11 |
Details | BINDING SITE FOR RESIDUE DTY C 1371 |
Chain | Residue |
C | THR162 |
C | GLN166 |
C | ALA169 |
C | GLY193 |
C | LEU194 |
C | SER195 |
C | GLY226 |
C | VAL227 |
D | GLU21 |
D | ASP22 |
D | TYR28 |
site_id | BC3 |
Number of Residues | 11 |
Details | BINDING SITE FOR RESIDUE DTY D 1370 |
Chain | Residue |
C | GLU21 |
C | ASP22 |
C | TYR28 |
D | THR162 |
D | GLN166 |
D | ALA169 |
D | GLY193 |
D | LEU194 |
D | SER195 |
D | GLY226 |
D | VAL227 |
site_id | BC4 |
Number of Residues | 11 |
Details | BINDING SITE FOR RESIDUE DTY E 1370 |
Chain | Residue |
E | THR162 |
E | GLN166 |
E | ALA169 |
E | GLY193 |
E | LEU194 |
E | SER195 |
E | GLY226 |
E | VAL227 |
F | GLU21 |
F | ASP22 |
F | TYR28 |
site_id | BC5 |
Number of Residues | 11 |
Details | BINDING SITE FOR RESIDUE DTY F 1370 |
Chain | Residue |
F | SER195 |
F | VAL227 |
E | GLU21 |
E | ASP22 |
E | ILE25 |
E | TYR28 |
F | THR162 |
F | GLN166 |
F | ALA169 |
F | GLY193 |
F | LEU194 |
site_id | BC6 |
Number of Residues | 11 |
Details | BINDING SITE FOR RESIDUE DTY G 1369 |
Chain | Residue |
G | THR162 |
G | GLN166 |
G | ALA169 |
G | GLY193 |
G | LEU194 |
G | SER195 |
G | GLY226 |
G | VAL227 |
H | GLU21 |
H | ASP22 |
H | TYR28 |
site_id | BC7 |
Number of Residues | 11 |
Details | BINDING SITE FOR RESIDUE DTY H 1369 |
Chain | Residue |
G | GLU21 |
G | ASP22 |
G | TYR28 |
H | THR162 |
H | GLN166 |
H | ALA169 |
H | GLY193 |
H | LEU194 |
H | SER195 |
H | GLY226 |
H | VAL227 |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 8 |
Details | MOD_RES: N-acetylserine => ECO:0007744|PubMed:22814378 |
Chain | Residue | Details |
A | SER2 | |
B | SER2 | |
C | SER2 | |
D | SER2 | |
E | SER2 | |
F | SER2 | |
G | SER2 | |
H | SER2 |
Catalytic Information from CSA
site_id | CSA1 |
Number of Residues | 1 |
Details | Annotated By Reference To The Literature 1q3n |
Chain | Residue | Details |
A | HIS282 |
site_id | CSA2 |
Number of Residues | 1 |
Details | Annotated By Reference To The Literature 1q3n |
Chain | Residue | Details |
B | HIS282 |
site_id | CSA3 |
Number of Residues | 1 |
Details | Annotated By Reference To The Literature 1q3n |
Chain | Residue | Details |
C | HIS282 |
site_id | CSA4 |
Number of Residues | 1 |
Details | Annotated By Reference To The Literature 1q3n |
Chain | Residue | Details |
D | HIS282 |
site_id | CSA5 |
Number of Residues | 1 |
Details | Annotated By Reference To The Literature 1q3n |
Chain | Residue | Details |
E | HIS282 |
site_id | CSA6 |
Number of Residues | 1 |
Details | Annotated By Reference To The Literature 1q3n |
Chain | Residue | Details |
F | HIS282 |
site_id | CSA7 |
Number of Residues | 1 |
Details | Annotated By Reference To The Literature 1q3n |
Chain | Residue | Details |
G | HIS282 |
site_id | CSA8 |
Number of Residues | 1 |
Details | Annotated By Reference To The Literature 1q3n |
Chain | Residue | Details |
H | HIS282 |