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1ODO

1.85 A structure of CYP154A1 from Streptomyces coelicolor A3(2)

Functional Information from GO Data
ChainGOidnamespacecontents
A0004497molecular_functionmonooxygenase activity
A0005506molecular_functioniron ion binding
A0006707biological_processcholesterol catabolic process
A0008395molecular_functionsteroid hydroxylase activity
A0016491molecular_functionoxidoreductase activity
A0016705molecular_functionoxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
A0020037molecular_functionheme binding
A0036199molecular_functioncholest-4-en-3-one 26-monooxygenase activity
A0046872molecular_functionmetal ion binding
Functional Information from PDB Data
site_idAC1
Number of Residues19
DetailsBINDING SITE FOR RESIDUE HEM A 1407
ChainResidue
AMET87
AARG295
ATYR319
AALA346
APHE347
AHIS352
ACYS354
AGLY356
APIM1408
AHOH2409
AHOH2454
AHIS95
AARG99
APHE106
AMET239
AALA242
ATHR246
ATHR247
ALEU283

site_idAC2
Number of Residues8
DetailsBINDING SITE FOR RESIDUE PIM A 1408
ChainResidue
ATRP81
APHE88
ALEU238
ASER241
AALA242
ATHR246
AHEM1407
AHOH2314

Functional Information from PROSITE/UniProt
site_idPS00086
Number of Residues10
DetailsCYTOCHROME_P450 Cytochrome P450 cysteine heme-iron ligand signature. FGhGVHFCLG
ChainResidueDetails
APHE347-GLY356

218853

PDB entries from 2024-04-24

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