1OC4
Lactate dehydrogenase from Plasmodium berghei
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003824 | molecular_function | catalytic activity |
| A | 0004459 | molecular_function | L-lactate dehydrogenase activity |
| A | 0006089 | biological_process | lactate metabolic process |
| A | 0006090 | biological_process | pyruvate metabolic process |
| A | 0006096 | biological_process | glycolytic process |
| A | 0016491 | molecular_function | oxidoreductase activity |
| A | 0016616 | molecular_function | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor |
| A | 0019752 | biological_process | carboxylic acid metabolic process |
| A | 0042866 | biological_process | pyruvate biosynthetic process |
| A | 0051287 | molecular_function | NAD binding |
| B | 0003824 | molecular_function | catalytic activity |
| B | 0004459 | molecular_function | L-lactate dehydrogenase activity |
| B | 0006089 | biological_process | lactate metabolic process |
| B | 0006090 | biological_process | pyruvate metabolic process |
| B | 0006096 | biological_process | glycolytic process |
| B | 0016491 | molecular_function | oxidoreductase activity |
| B | 0016616 | molecular_function | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor |
| B | 0019752 | biological_process | carboxylic acid metabolic process |
| B | 0042866 | biological_process | pyruvate biosynthetic process |
| B | 0051287 | molecular_function | NAD binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 21 |
| Details | BINDING SITE FOR RESIDUE NAD A1330 |
| Chain | Residue |
| A | GLY27 |
| A | ALA98 |
| A | GLY99 |
| A | PHE100 |
| A | THR101 |
| A | ILE119 |
| A | ILE123 |
| A | VAL138 |
| A | ASN140 |
| A | LEU163 |
| A | LEU167 |
| A | GLY29 |
| A | HIS195 |
| A | OXM1331 |
| A | MET30 |
| A | ILE31 |
| A | PHE52 |
| A | ASP53 |
| A | ILE54 |
| A | TYR85 |
| A | THR97 |
| site_id | AC2 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE OXM A1331 |
| Chain | Residue |
| A | ARG109 |
| A | LEU167 |
| A | ARG171 |
| A | HIS195 |
| A | PRO246 |
| A | NAD1330 |
| site_id | AC3 |
| Number of Residues | 24 |
| Details | BINDING SITE FOR RESIDUE NAD B1330 |
| Chain | Residue |
| B | GLY27 |
| B | GLY29 |
| B | MET30 |
| B | ILE31 |
| B | PHE52 |
| B | ASP53 |
| B | ILE54 |
| B | VAL55 |
| B | TYR85 |
| B | THR97 |
| B | ALA98 |
| B | GLY99 |
| B | PHE100 |
| B | THR101 |
| B | ILE119 |
| B | VAL138 |
| B | ASN140 |
| B | LEU163 |
| B | LEU167 |
| B | HIS195 |
| B | OXM1331 |
| B | HOH2097 |
| B | HOH2127 |
| B | HOH2128 |
| site_id | AC4 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE OXM B1331 |
| Chain | Residue |
| B | TRP107 |
| B | ARG109 |
| B | ASN140 |
| B | LEU167 |
| B | ARG171 |
| B | HIS195 |
| B | ALA236 |
| B | PRO246 |
| B | NAD1330 |
| site_id | AC5 |
| Number of Residues | 10 |
| Details | BINDING SITE FOR RESIDUE GOL A1332 |
| Chain | Residue |
| A | THR169 |
| A | LYS173 |
| A | ASN188 |
| A | ALA189 |
| A | VAL268 |
| A | ILE270 |
| A | HOH2062 |
| A | HOH2063 |
| A | HOH2064 |
| B | GLY209 |
| site_id | AC6 |
| Number of Residues | 10 |
| Details | BINDING SITE FOR RESIDUE GOL B1332 |
| Chain | Residue |
| A | GLY209 |
| B | THR169 |
| B | LYS173 |
| B | ASN188 |
| B | ALA189 |
| B | VAL268 |
| B | ILE270 |
| B | HOH2129 |
| B | HOH2130 |
| B | HOH2131 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | ACT_SITE: Proton acceptor => ECO:0000269|PubMed:12967707 |
| Chain | Residue | Details |
| A | HIS195 | |
| B | HIS195 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 16 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:12967707 |
| Chain | Residue | Details |
| A | GLY29 | |
| B | PHE52 | |
| B | TYR85 | |
| B | THR97 | |
| B | ARG109 | |
| B | VAL138 | |
| B | ARG171 | |
| B | HIS195 | |
| A | PHE52 | |
| A | TYR85 | |
| A | THR97 | |
| A | ARG109 | |
| A | VAL138 | |
| A | ARG171 | |
| A | HIS195 | |
| B | GLY29 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 4 |
| Details | BINDING: |
| Chain | Residue | Details |
| A | LEU163 | |
| A | LEU167 | |
| B | LEU163 | |
| B | LEU167 |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1emd |
| Chain | Residue | Details |
| A | HIS195 | |
| A | ASP168 |
| site_id | CSA2 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1emd |
| Chain | Residue | Details |
| B | HIS195 | |
| B | ASP168 |
| site_id | CSA3 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1emd |
| Chain | Residue | Details |
| A | HIS195 | |
| A | ARG171 | |
| A | ASP168 |
| site_id | CSA4 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1emd |
| Chain | Residue | Details |
| B | HIS195 | |
| B | ARG171 | |
| B | ASP168 |
