1O9S
Crystal structure of a ternary complex of the human histone methyltransferase SET7/9
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0005694 | cellular_component | chromosome |
A | 0006355 | biological_process | regulation of DNA-templated transcription |
A | 0016279 | molecular_function | protein-lysine N-methyltransferase activity |
A | 0140945 | molecular_function | histone H3K4 monomethyltransferase activity |
B | 0005694 | cellular_component | chromosome |
B | 0006355 | biological_process | regulation of DNA-templated transcription |
B | 0016279 | molecular_function | protein-lysine N-methyltransferase activity |
B | 0140945 | molecular_function | histone H3K4 monomethyltransferase activity |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 17 |
Details | BINDING SITE FOR RESIDUE SAH A1367 |
Chain | Residue |
A | ALA226 |
A | GLU356 |
A | HOH2302 |
A | HOH2303 |
A | HOH2307 |
A | HOH2308 |
A | HOH2309 |
A | HOH2310 |
K | MLZ4 |
A | GLU228 |
A | ASN265 |
A | HIS293 |
A | LYS294 |
A | ASN296 |
A | HIS297 |
A | TYR335 |
A | TRP352 |
site_id | AC2 |
Number of Residues | 17 |
Details | BINDING SITE FOR RESIDUE SAH B1367 |
Chain | Residue |
B | ALA226 |
B | GLU228 |
B | ASN265 |
B | HIS293 |
B | LYS294 |
B | ASN296 |
B | HIS297 |
B | TYR335 |
B | TRP352 |
B | GLU356 |
B | HOH2322 |
B | HOH2324 |
B | HOH2325 |
B | HOH2326 |
B | HOH2327 |
B | HOH2328 |
L | MLZ4 |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 2 |
Details | MOD_RES: Citrulline; alternate => ECO:0000269|PubMed:16567635 |
Chain | Residue | Details |
K | ARG2 | |
L | ARG2 | |
A | HIS297 | |
B | ALA226 | |
B | ASN296 | |
B | HIS297 |
site_id | SWS_FT_FI2 |
Number of Residues | 2 |
Details | MOD_RES: Phosphothreonine; by HASPIN and VRK1 => ECO:0000269|PubMed:15681610, ECO:0000269|PubMed:16185088, ECO:0000269|PubMed:31527692 |
Chain | Residue | Details |
K | THR3 | |
L | THR3 |
site_id | SWS_FT_FI3 |
Number of Residues | 2 |
Details | MOD_RES: N6-methyllysine; alternate => ECO:0000269|PubMed:16267050, ECO:0000269|PubMed:16457588, ECO:0000269|PubMed:17194708 |
Chain | Residue | Details |
K | MLZ4 | |
B | TYR335 | |
L | MLZ4 | |
A | THR266 | |
A | LYS317 | |
A | TYR335 | |
B | TYR245 | |
B | ASP256 | |
B | THR266 | |
B | LYS317 |
site_id | SWS_FT_FI4 |
Number of Residues | 2 |
Details | MOD_RES: 5-glutamyl serotonin; alternate => ECO:0000269|PubMed:30867594 |
Chain | Residue | Details |
K | GLN5 | |
L | GLN5 |
site_id | SWS_FT_FI5 |
Number of Residues | 2 |
Details | MOD_RES: Phosphothreonine; by PKC => ECO:0000269|PubMed:20228790 |
Chain | Residue | Details |
K | THR6 | |
L | THR6 |
site_id | SWS_FT_FI6 |
Number of Residues | 2 |
Details | MOD_RES: Symmetric dimethylarginine; by PRMT5; alternate => ECO:0000250|UniProtKB:P68433 |
Chain | Residue | Details |
K | ARG8 | |
L | ARG8 |
site_id | SWS_FT_FI7 |
Number of Residues | 2 |
Details | MOD_RES: N6-methyllysine; alternate => ECO:0000269|PubMed:11242053, ECO:0000269|PubMed:16185088, ECO:0000269|PubMed:16267050, ECO:0000269|PubMed:16457588, ECO:0000269|PubMed:17194708 |
Chain | Residue | Details |
K | LYS9 | |
L | LYS9 |
site_id | SWS_FT_FI8 |
Number of Residues | 2 |
Details | MOD_RES: Phosphoserine; alternate; by AURKB, AURKC, RPS6KA3, RPS6KA4 and RPS6KA5 => ECO:0000269|PubMed:10464286, ECO:0000269|PubMed:11856369, ECO:0000269|PubMed:12560483, ECO:0000269|PubMed:15681610, ECO:0000269|PubMed:16185088, ECO:0000269|PubMed:16457588 |
Chain | Residue | Details |
K | TYR10 | |
L | TYR10 |
Catalytic Information from CSA
site_id | CSA1 |
Number of Residues | 2 |
Details | Annotated By Reference To The Literature 1h3i |
Chain | Residue | Details |
A | TYR335 | |
A | HIS293 |
site_id | CSA2 |
Number of Residues | 2 |
Details | Annotated By Reference To The Literature 1h3i |
Chain | Residue | Details |
B | TYR335 | |
B | HIS293 |
site_id | MCSA1 |
Number of Residues | 5 |
Details | M-CSA 350 |
Chain | Residue | Details |
A | TYR245 | activator, electrostatic stabiliser, hydrogen bond acceptor, hydrogen bond donor |
A | HIS293 | electrostatic stabiliser, hydrogen bond acceptor |
A | HIS297 | electrostatic stabiliser, hydrogen bond acceptor |
A | TYR305 | activator, electrostatic stabiliser, hydrogen bond acceptor |
A | TYR335 | activator, electrostatic stabiliser, hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor |
site_id | MCSA2 |
Number of Residues | 5 |
Details | M-CSA 350 |
Chain | Residue | Details |
B | TYR245 | activator, electrostatic stabiliser, hydrogen bond acceptor, hydrogen bond donor |
B | HIS293 | electrostatic stabiliser, hydrogen bond acceptor |
B | HIS297 | electrostatic stabiliser, hydrogen bond acceptor |
B | TYR305 | activator, electrostatic stabiliser, hydrogen bond acceptor |
B | TYR335 | activator, electrostatic stabiliser, hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor |