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Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

1O7J

Atomic resolution structure of Erwinia chrysanthemi L-asparaginase

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004067	molecular_function	asparaginase activity
A	0006520	biological_process	amino acid metabolic process
A	0006528	biological_process	asparagine metabolic process
A	0016787	molecular_function	hydrolase activity
B	0004067	molecular_function	asparaginase activity
B	0006520	biological_process	amino acid metabolic process
B	0006528	biological_process	asparagine metabolic process
B	0016787	molecular_function	hydrolase activity
C	0004067	molecular_function	asparaginase activity
C	0006520	biological_process	amino acid metabolic process
C	0006528	biological_process	asparagine metabolic process
C	0016787	molecular_function	hydrolase activity
D	0004067	molecular_function	asparaginase activity
D	0006520	biological_process	amino acid metabolic process
D	0006528	biological_process	asparagine metabolic process
D	0016787	molecular_function	hydrolase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	9
Details	BINDING SITE FOR RESIDUE SO4 A1328

Chain	Residue
A	GLY14
A	THR15
A	ALA61
A	SER62
A	GLY94
A	THR95
A	ASP96
A	HOH2111
A	HOH2114

site_id	AC2
Number of Residues	5
Details	BINDING SITE FOR RESIDUE SO4 A1329

Chain	Residue
A	MET60
A	ALA61
A	ASN64
A	HOH2029
A	HOH2343

site_id	AC3
Number of Residues	10
Details	BINDING SITE FOR RESIDUE SO4 B1328

Chain	Residue
B	GLY14
B	THR15
B	ALA31
B	ALA61
B	SER62
B	GLY94
B	THR95
B	ASP96
B	HOH2094
B	HOH2095

site_id	AC4
Number of Residues	10
Details	BINDING SITE FOR RESIDUE SO4 B1329

Chain	Residue
B	LEU267
B	LEU290
B	GLY292
B	HOH2307
B	HOH2308
B	HOH2309
B	HOH2310
D	THR314
D	SER315
D	HOH2330

site_id	AC5
Number of Residues	8
Details	BINDING SITE FOR RESIDUE SO4 C1328

Chain	Residue
C	GLY14
C	THR15
C	ALA61
C	SER62
C	GLY94
C	THR95
C	ASP96
C	HOH2353

site_id	AC6
Number of Residues	5
Details	BINDING SITE FOR RESIDUE SO4 C1329

Chain	Residue
C	MET60
C	ALA61
C	ASN64
C	HOH2354
C	HOH2355

site_id	AC7
Number of Residues	9
Details	BINDING SITE FOR RESIDUE SO4 D1328

Chain	Residue
D	GLY14
D	THR15
D	ALA61
D	SER62
D	GLY94
D	THR95
D	ASP96
D	HOH2127
D	HOH2131

site_id	AC8
Number of Residues	6
Details	BINDING SITE FOR RESIDUE SO4 D1329

Chain	Residue
D	MET60
D	ALA61
D	ASN64
D	HOH2344
D	HOH2345
D	HOH2346

site_id	AC9
Number of Residues	4
Details	BINDING SITE FOR RESIDUE EDO A1331

Chain	Residue
A	LYS243
A	EDO1332
A	EDO1335
C	THR312

site_id	BC1
Number of Residues	5
Details	BINDING SITE FOR RESIDUE EDO A1332

Chain	Residue
A	LYS243
A	EDO1331
A	EDO1333
C	ASP210
C	HOH2330

site_id	BC2
Number of Residues	5
Details	BINDING SITE FOR RESIDUE EDO A1333

Chain	Residue
A	LYS243
A	EDO1332
A	EDO1334
C	ASP210
C	ARG212

site_id	BC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE EDO A1334

Chain	Residue
A	LYS243
A	GLY270
A	EDO1333
A	EDO1335

site_id	BC4
Number of Residues	4
Details	BINDING SITE FOR RESIDUE EDO A1335

Chain	Residue
A	LYS243
A	EDO1331
A	EDO1334
A	HOH2348

site_id	BC5
Number of Residues	3
Details	BINDING SITE FOR RESIDUE EDO B1330

Chain	Residue
B	GLN75
B	EDO1331
D	THR205

site_id	BC6
Number of Residues	5
Details	BINDING SITE FOR RESIDUE EDO B1331

Chain	Residue
B	GLN75
B	ARG212
B	EDO1330
B	EDO1332
D	ARG206

site_id	BC7
Number of Residues	3
Details	BINDING SITE FOR RESIDUE EDO B1332

Chain	Residue
B	ASN78
B	ARG212
B	EDO1331

site_id	BC8
Number of Residues	5
Details	BINDING SITE FOR RESIDUE EDO D1331

Chain	Residue
D	EDO1334
D	VAL69
D	LYS72
D	EDO1332
D	EDO1333

site_id	BC9
Number of Residues	3
Details	BINDING SITE FOR RESIDUE EDO D1332

Chain	Residue
D	LYS72
D	EDO1331
D	EDO1333

site_id	CC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE EDO D1333

Chain	Residue
D	LYS72
D	EDO1331
D	EDO1332
D	EDO1334

site_id	CC2
Number of Residues	3
Details	BINDING SITE FOR RESIDUE EDO D1334

Chain	Residue
D	LYS72
D	EDO1331
D	EDO1333

site_id	CC3
Number of Residues	7
Details	BINDING SITE FOR RESIDUE GOL A1330

Chain	Residue
A	ASP68
A	SER216
A	LEU217
A	HOH2344
A	HOH2345
A	HOH2346
C	THR215

site_id	CC4
Number of Residues	8
Details	BINDING SITE FOR RESIDUE GOL D1330

Chain	Residue
A	ASN180
A	GLU181
C	ARG178
C	HOH2202
D	ARG159
D	ASN180
D	TYR184
D	HOH2347

Functional Information from PROSITE/UniProt

site_id	PS00144
Number of Residues	9
Details	ASN_GLN_ASE_1 Asparaginase / glutaminase active site signature 1. IlATGGTIA

Chain	Residue	Details
A	ILE9-ALA17

site_id	PS00917
Number of Residues	11
Details	ASN_GLN_ASE_2 Asparaginase / glutaminase active site signature 2. GvVitHGTDTV

Chain	Residue	Details
A	GLY88-VAL98

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1288
Details	Domain: {"description":"Asparaginase/glutaminase","evidences":[{"source":"PROSITE-ProRule","id":"PRU01068","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	4
Details	Active site: {"description":"O-isoaspartyl threonine intermediate","evidences":[{"source":"PROSITE-ProRule","id":"PRU10099","evidenceCode":"ECO:0000255"},{"source":"PROSITE-ProRule","id":"PRU10100","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"11755201","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"8348975","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	8
Details	Binding site: {}

Chain

Residue

Details

Catalytic Information from CSA

site_id	CSA1
Number of Residues	5
Details	Annotated By Reference To The Literature 3eca

Chain	Residue	Details
A	THR15
A	THR95
A	ASP96
A	TYR29
A	LYS168

site_id	CSA2
Number of Residues	5
Details	Annotated By Reference To The Literature 3eca

Chain	Residue	Details
B	THR15
B	THR95
B	ASP96
B	TYR29
B	LYS168

site_id	CSA3
Number of Residues	5
Details	Annotated By Reference To The Literature 3eca

Chain	Residue	Details
C	THR15
C	THR95
C	ASP96
C	TYR29
C	LYS168

site_id	CSA4
Number of Residues	5
Details	Annotated By Reference To The Literature 3eca

Chain	Residue	Details
D	THR15
D	THR95
D	ASP96
D	TYR29
D	LYS168

site_id	CSA5
Number of Residues	4
Details	Annotated By Reference To The Literature 3eca

Chain	Residue	Details
A	VAL284
C	THR15
C	THR95
C	TYR29

site_id	CSA6
Number of Residues	4
Details	Annotated By Reference To The Literature 3eca

Chain	Residue	Details
D	THR15
D	THR95
D	TYR29
B	VAL284

site_id	CSA7
Number of Residues	4
Details	Annotated By Reference To The Literature 3eca

Chain	Residue	Details
A	THR15
A	THR95
A	TYR29
C	VAL284

site_id	CSA8
Number of Residues	4
Details	Annotated By Reference To The Literature 3eca

Chain	Residue	Details
D	VAL284
B	THR15
B	THR95
B	TYR29

247536

PDB entries from 2026-01-14

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