1O68
Crystal structure of 3-methyl-2-oxobutanoate hydroxymethyltransferase
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000287 | molecular_function | magnesium ion binding |
| A | 0003824 | molecular_function | catalytic activity |
| A | 0003864 | molecular_function | 3-methyl-2-oxobutanoate hydroxymethyltransferase activity |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0015940 | biological_process | pantothenate biosynthetic process |
| A | 0016740 | molecular_function | transferase activity |
| A | 0046872 | molecular_function | metal ion binding |
| B | 0000287 | molecular_function | magnesium ion binding |
| B | 0003824 | molecular_function | catalytic activity |
| B | 0003864 | molecular_function | 3-methyl-2-oxobutanoate hydroxymethyltransferase activity |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0015940 | biological_process | pantothenate biosynthetic process |
| B | 0016740 | molecular_function | transferase activity |
| B | 0046872 | molecular_function | metal ion binding |
| C | 0000287 | molecular_function | magnesium ion binding |
| C | 0003824 | molecular_function | catalytic activity |
| C | 0003864 | molecular_function | 3-methyl-2-oxobutanoate hydroxymethyltransferase activity |
| C | 0005737 | cellular_component | cytoplasm |
| C | 0015940 | biological_process | pantothenate biosynthetic process |
| C | 0016740 | molecular_function | transferase activity |
| C | 0046872 | molecular_function | metal ion binding |
| D | 0000287 | molecular_function | magnesium ion binding |
| D | 0003824 | molecular_function | catalytic activity |
| D | 0003864 | molecular_function | 3-methyl-2-oxobutanoate hydroxymethyltransferase activity |
| D | 0005737 | cellular_component | cytoplasm |
| D | 0015940 | biological_process | pantothenate biosynthetic process |
| D | 0016740 | molecular_function | transferase activity |
| D | 0046872 | molecular_function | metal ion binding |
| E | 0000287 | molecular_function | magnesium ion binding |
| E | 0003824 | molecular_function | catalytic activity |
| E | 0003864 | molecular_function | 3-methyl-2-oxobutanoate hydroxymethyltransferase activity |
| E | 0005737 | cellular_component | cytoplasm |
| E | 0015940 | biological_process | pantothenate biosynthetic process |
| E | 0016740 | molecular_function | transferase activity |
| E | 0046872 | molecular_function | metal ion binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE NA A 274 |
| Chain | Residue |
| A | ASP43 |
| A | ASP82 |
| A | LYS111 |
| A | KIV275 |
| A | HOH327 |
| A | HOH341 |
| site_id | AC2 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE NA D 274 |
| Chain | Residue |
| D | KIV275 |
| D | HOH311 |
| D | HOH312 |
| D | HOH375 |
| D | ASP43 |
| D | ASP82 |
| D | LYS111 |
| site_id | AC3 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE NA B 274 |
| Chain | Residue |
| B | ASP43 |
| B | ASP82 |
| B | LYS111 |
| B | KIV275 |
| B | HOH314 |
| B | HOH389 |
| site_id | AC4 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE NA E 274 |
| Chain | Residue |
| E | ASP43 |
| E | ASP82 |
| E | LYS111 |
| E | KIV275 |
| E | HOH345 |
| site_id | AC5 |
| Number of Residues | 10 |
| Details | BINDING SITE FOR RESIDUE KIV A 275 |
| Chain | Residue |
| A | THR21 |
| A | LEU40 |
| A | GLY42 |
| A | ASP43 |
| A | SER44 |
| A | ASP82 |
| A | LYS111 |
| A | HIS135 |
| A | GLU179 |
| A | NA274 |
| site_id | AC6 |
| Number of Residues | 10 |
| Details | BINDING SITE FOR RESIDUE KIV D 275 |
| Chain | Residue |
| D | THR21 |
| D | LEU40 |
| D | GLY42 |
| D | ASP43 |
| D | SER44 |
| D | ASP82 |
| D | LYS111 |
| D | ILE200 |
| D | NA274 |
| D | HOH375 |
| site_id | AC7 |
| Number of Residues | 10 |
| Details | BINDING SITE FOR RESIDUE KIV B 275 |
| Chain | Residue |
| B | THR21 |
| B | LEU40 |
| B | GLY42 |
| B | ASP43 |
| B | SER44 |
| B | ASP82 |
| B | LYS111 |
| B | VAL210 |
| B | VAL212 |
| B | NA274 |
| site_id | AC8 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE KIV E 275 |
| Chain | Residue |
| E | THR21 |
| E | LEU40 |
| E | GLY42 |
| E | ASP43 |
| E | SER44 |
| E | ASP82 |
| E | LYS111 |
| E | ILE200 |
| E | NA274 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 5 |
| Details | ACT_SITE: Proton acceptor => ECO:0000255|HAMAP-Rule:MF_00156 |
| Chain | Residue | Details |
| A | GLU179 | |
| B | GLU179 | |
| C | GLU179 | |
| D | GLU179 | |
| E | GLU179 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 15 |
| Details | BINDING: BINDING => ECO:0000255|HAMAP-Rule:MF_00156 |
| Chain | Residue | Details |
| A | ASP43 | |
| D | ASP43 | |
| D | ASP82 | |
| D | GLU113 | |
| E | ASP43 | |
| E | ASP82 | |
| E | GLU113 | |
| A | ASP82 | |
| A | GLU113 | |
| B | ASP43 | |
| B | ASP82 | |
| B | GLU113 | |
| C | ASP43 | |
| C | ASP82 | |
| C | GLU113 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 5 |
| Details | BINDING: |
| Chain | Residue | Details |
| A | LYS111 | |
| B | LYS111 | |
| C | LYS111 | |
| D | LYS111 | |
| E | LYS111 |
