1O68

Crystal structure of 3-methyl-2-oxobutanoate hydroxymethyltransferase

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000287	molecular_function	magnesium ion binding
A	0003824	molecular_function	catalytic activity
A	0003864	molecular_function	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
A	0005737	cellular_component	cytoplasm
A	0015940	biological_process	pantothenate biosynthetic process
A	0016740	molecular_function	transferase activity
A	0046872	molecular_function	metal ion binding
B	0000287	molecular_function	magnesium ion binding
B	0003824	molecular_function	catalytic activity
B	0003864	molecular_function	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
B	0005737	cellular_component	cytoplasm
B	0015940	biological_process	pantothenate biosynthetic process
B	0016740	molecular_function	transferase activity
B	0046872	molecular_function	metal ion binding
C	0000287	molecular_function	magnesium ion binding
C	0003824	molecular_function	catalytic activity
C	0003864	molecular_function	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
C	0005737	cellular_component	cytoplasm
C	0015940	biological_process	pantothenate biosynthetic process
C	0016740	molecular_function	transferase activity
C	0046872	molecular_function	metal ion binding
D	0000287	molecular_function	magnesium ion binding
D	0003824	molecular_function	catalytic activity
D	0003864	molecular_function	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
D	0005737	cellular_component	cytoplasm
D	0015940	biological_process	pantothenate biosynthetic process
D	0016740	molecular_function	transferase activity
D	0046872	molecular_function	metal ion binding
E	0000287	molecular_function	magnesium ion binding
E	0003824	molecular_function	catalytic activity
E	0003864	molecular_function	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
E	0005737	cellular_component	cytoplasm
E	0015940	biological_process	pantothenate biosynthetic process
E	0016740	molecular_function	transferase activity
E	0046872	molecular_function	metal ion binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	6
Details	BINDING SITE FOR RESIDUE NA A 274

Chain	Residue
A	ASP43
A	ASP82
A	LYS111
A	KIV275
A	HOH327
A	HOH341

---

site_id	AC2
Number of Residues	7
Details	BINDING SITE FOR RESIDUE NA D 274

Chain	Residue
D	KIV275
D	HOH311
D	HOH312
D	HOH375
D	ASP43
D	ASP82
D	LYS111

---

site_id	AC3
Number of Residues	6
Details	BINDING SITE FOR RESIDUE NA B 274

Chain	Residue
B	ASP43
B	ASP82
B	LYS111
B	KIV275
B	HOH314
B	HOH389

---

site_id	AC4
Number of Residues	5
Details	BINDING SITE FOR RESIDUE NA E 274

Chain	Residue
E	ASP43
E	ASP82
E	LYS111
E	KIV275
E	HOH345

---

site_id	AC5
Number of Residues	10
Details	BINDING SITE FOR RESIDUE KIV A 275

Chain	Residue
A	THR21
A	LEU40
A	GLY42
A	ASP43
A	SER44
A	ASP82
A	LYS111
A	HIS135
A	GLU179
A	NA274

---

site_id	AC6
Number of Residues	10
Details	BINDING SITE FOR RESIDUE KIV D 275

Chain	Residue
D	THR21
D	LEU40
D	GLY42
D	ASP43
D	SER44
D	ASP82
D	LYS111
D	ILE200
D	NA274
D	HOH375

---

site_id	AC7
Number of Residues	10
Details	BINDING SITE FOR RESIDUE KIV B 275

Chain	Residue
B	THR21
B	LEU40
B	GLY42
B	ASP43
B	SER44
B	ASP82
B	LYS111
B	VAL210
B	VAL212
B	NA274

---

site_id	AC8
Number of Residues	9
Details	BINDING SITE FOR RESIDUE KIV E 275

Chain	Residue
E	THR21
E	LEU40
E	GLY42
E	ASP43
E	SER44
E	ASP82
E	LYS111
E	ILE200
E	NA274

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	5
Details	Active site: {"description":"Proton acceptor","evidences":[{"source":"HAMAP-Rule","id":"MF_00156","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	7
Details	Binding site: {}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	12
Details	Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_00156","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---