Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004326 | molecular_function | tetrahydrofolylpolyglutamate synthase activity |
| A | 0005524 | molecular_function | ATP binding |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0006761 | biological_process | dihydrofolate biosynthetic process |
| A | 0008841 | molecular_function | dihydrofolate synthase activity |
| A | 0009058 | biological_process | biosynthetic process |
| A | 0009396 | biological_process | folic acid-containing compound biosynthetic process |
| A | 0016874 | molecular_function | ligase activity |
| A | 0016881 | molecular_function | acid-amino acid ligase activity |
| A | 0046872 | molecular_function | metal ion binding |
| A | 0046901 | biological_process | tetrahydrofolylpolyglutamate biosynthetic process |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 10 |
| Details | BINDING SITE FOR RESIDUE SO4 A 501 |
| Chain | Residue |
| A | GLY47 |
| A | HOH941 |
| A | THR48 |
| A | LYS51 |
| A | GLY145 |
| A | LEU146 |
| A | GLY147 |
| A | LYS185 |
| A | HOH727 |
| A | HOH887 |
| site_id | AC2 |
| Number of Residues | 10 |
| Details | BINDING SITE FOR RESIDUE SO4 A 502 |
| Chain | Residue |
| A | ASN49 |
| A | GLY50 |
| A | LYS51 |
| A | GLY52 |
| A | SER53 |
| A | ASN292 |
| A | ARG295 |
| A | UNL701 |
| A | HOH771 |
| A | HOH933 |
| site_id | AC3 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE SO4 A 503 |
| Chain | Residue |
| A | HIS312 |
| A | LEU340 |
| A | LYS343 |
| A | ARG368 |
| A | SER408 |
| A | LEU409 |
| A | PHE410 |
| A | HOH720 |
| A | HOH836 |
| site_id | AC4 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE SO4 A 504 |
| Chain | Residue |
| A | ARG363 |
| A | LYS370 |
| A | ASP371 |
| A | MET372 |
| A | ASN373 |
| site_id | AC5 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE CL A 601 |
| Chain | Residue |
| A | SER334 |
| A | ARG358 |
| A | THR399 |
| A | GLU400 |
| A | ARG401 |
| site_id | AC6 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE CL A 602 |
| site_id | AC7 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE UNL A 701 |
| Chain | Residue |
| A | LYS51 |
| A | SER74 |
| A | GLU143 |
| A | VAL144 |
| A | GLY145 |
| A | SO4502 |
| A | HOH770 |
| A | HOH999 |
| A | HOH1021 |
| site_id | AC8 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE UNL A 702 |
| Chain | Residue |
| A | GLU113 |
| A | LYS304 |
| A | GLU397 |
| A | THR399 |
| A | GLU400 |
Functional Information from PROSITE/UniProt
| site_id | PS01011 |
| Number of Residues | 24 |
| Details | FOLYLPOLYGLU_SYNT_1 Folylpolyglutamate synthase signature 1. IhIGGTNGKgSvanmVsNILvsq.G |
| Chain | Residue | Details |
| A | ILE43-GLY66 | |
| site_id | PS01012 |
| Number of Residues | 16 |
| Details | FOLYLPOLYGLU_SYNT_2 Folylpolyglutamate synthase signature 2. VLEvGLGGrlDaTnVV |
| Chain | Residue | Details |
| A | VAL141-VAL156 | |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 1 |
| Details | Annotated By Reference To The Literature 1p3d |
| Chain | Residue | Details |
| A | LYS51 | |
