1O5W
The structure basis of specific recognitions for substrates and inhibitors of rat monoamine oxidase A
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005739 | cellular_component | mitochondrion |
| A | 0005741 | cellular_component | mitochondrial outer membrane |
| A | 0006584 | biological_process | catecholamine metabolic process |
| A | 0008131 | molecular_function | primary methylamine oxidase activity |
| A | 0009967 | biological_process | positive regulation of signal transduction |
| A | 0016491 | molecular_function | oxidoreductase activity |
| A | 0042420 | biological_process | dopamine catabolic process |
| A | 0042424 | biological_process | catecholamine catabolic process |
| A | 0042428 | biological_process | serotonin metabolic process |
| A | 0042443 | biological_process | phenylethylamine metabolic process |
| A | 0050660 | molecular_function | flavin adenine dinucleotide binding |
| A | 0051378 | molecular_function | serotonin binding |
| A | 0052595 | molecular_function | aliphatic amine oxidase activity |
| A | 0097621 | molecular_function | monoamine oxidase activity |
| B | 0005739 | cellular_component | mitochondrion |
| B | 0005741 | cellular_component | mitochondrial outer membrane |
| B | 0006584 | biological_process | catecholamine metabolic process |
| B | 0008131 | molecular_function | primary methylamine oxidase activity |
| B | 0009967 | biological_process | positive regulation of signal transduction |
| B | 0016491 | molecular_function | oxidoreductase activity |
| B | 0042420 | biological_process | dopamine catabolic process |
| B | 0042424 | biological_process | catecholamine catabolic process |
| B | 0042428 | biological_process | serotonin metabolic process |
| B | 0042443 | biological_process | phenylethylamine metabolic process |
| B | 0050660 | molecular_function | flavin adenine dinucleotide binding |
| B | 0051378 | molecular_function | serotonin binding |
| B | 0052595 | molecular_function | aliphatic amine oxidase activity |
| B | 0097621 | molecular_function | monoamine oxidase activity |
| C | 0005739 | cellular_component | mitochondrion |
| C | 0005741 | cellular_component | mitochondrial outer membrane |
| C | 0006584 | biological_process | catecholamine metabolic process |
| C | 0008131 | molecular_function | primary methylamine oxidase activity |
| C | 0009967 | biological_process | positive regulation of signal transduction |
| C | 0016491 | molecular_function | oxidoreductase activity |
| C | 0042420 | biological_process | dopamine catabolic process |
| C | 0042424 | biological_process | catecholamine catabolic process |
| C | 0042428 | biological_process | serotonin metabolic process |
| C | 0042443 | biological_process | phenylethylamine metabolic process |
| C | 0050660 | molecular_function | flavin adenine dinucleotide binding |
| C | 0051378 | molecular_function | serotonin binding |
| C | 0052595 | molecular_function | aliphatic amine oxidase activity |
| C | 0097621 | molecular_function | monoamine oxidase activity |
| D | 0005739 | cellular_component | mitochondrion |
| D | 0005741 | cellular_component | mitochondrial outer membrane |
| D | 0006584 | biological_process | catecholamine metabolic process |
| D | 0008131 | molecular_function | primary methylamine oxidase activity |
| D | 0009967 | biological_process | positive regulation of signal transduction |
| D | 0016491 | molecular_function | oxidoreductase activity |
| D | 0042420 | biological_process | dopamine catabolic process |
| D | 0042424 | biological_process | catecholamine catabolic process |
| D | 0042428 | biological_process | serotonin metabolic process |
| D | 0042443 | biological_process | phenylethylamine metabolic process |
| D | 0050660 | molecular_function | flavin adenine dinucleotide binding |
| D | 0051378 | molecular_function | serotonin binding |
| D | 0052595 | molecular_function | aliphatic amine oxidase activity |
| D | 0097621 | molecular_function | monoamine oxidase activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 30 |
| Details | BINDING SITE FOR RESIDUE FAD A 652 |
| Chain | Residue |
| A | ILE19 |
| A | GLY50 |
| A | ARG51 |
| A | GLY66 |
| A | GLY67 |
| A | ALA68 |
| A | TYR69 |
| A | PRO243 |
| A | VAL244 |
| A | ALA272 |
| A | ILE273 |
| A | GLY20 |
| A | TRP397 |
| A | TYR402 |
| A | CYS406 |
| A | TYR407 |
| A | GLY434 |
| A | THR435 |
| A | GLY443 |
| A | TYR444 |
| A | MET445 |
| A | ALA448 |
| A | GLY22 |
| A | MLG709 |
| A | ILE23 |
| A | SER24 |
| A | GLU43 |
| A | ALA44 |
| A | ARG45 |
| A | GLY49 |
| site_id | AC2 |
| Number of Residues | 10 |
| Details | BINDING SITE FOR RESIDUE MLG A 709 |
| Chain | Residue |
| A | ILE180 |
| A | PHE208 |
| A | GLN215 |
| A | CYS323 |
| A | ILE335 |
| A | THR336 |
| A | LEU337 |
| A | TYR407 |
| A | TYR444 |
| A | FAD652 |
| site_id | AC3 |
| Number of Residues | 30 |
| Details | BINDING SITE FOR RESIDUE FAD B 1652 |
| Chain | Residue |
| B | ILE1019 |
| B | GLY1020 |
| B | GLY1021 |
| B | GLY1022 |
| B | ILE1023 |
| B | SER1024 |
| B | GLU1043 |
| B | ALA1044 |
| B | ARG1045 |
| B | GLY1049 |
| B | GLY1050 |
| B | ARG1051 |
| B | GLY1066 |
| B | GLY1067 |
| B | ALA1068 |
| B | TYR1069 |
| B | PRO1243 |
| B | VAL1244 |
| B | ALA1272 |
| B | ILE1273 |
| B | TYR1402 |
| B | CYS1406 |
| B | TYR1407 |
| B | GLY1434 |
| B | THR1435 |
| B | GLY1443 |
| B | TYR1444 |
| B | MET1445 |
| B | ALA1448 |
| B | MLG1709 |
| site_id | AC4 |
| Number of Residues | 11 |
| Details | BINDING SITE FOR RESIDUE MLG B 1709 |
| Chain | Residue |
| B | ILE1180 |
| B | PHE1208 |
| B | GLN1215 |
| B | CYS1323 |
| B | ILE1325 |
| B | ILE1335 |
| B | THR1336 |
| B | LEU1337 |
| B | TYR1407 |
| B | TYR1444 |
| B | FAD1652 |
| site_id | AC5 |
| Number of Residues | 30 |
| Details | BINDING SITE FOR RESIDUE FAD C 2652 |
| Chain | Residue |
| C | ALA2272 |
| C | ILE2273 |
| C | TRP2397 |
| C | TYR2402 |
| C | CYS2406 |
| C | TYR2407 |
| C | GLY2434 |
| C | THR2435 |
| C | GLY2443 |
| C | TYR2444 |
| C | MET2445 |
| C | MLG2709 |
| C | ILE2019 |
| C | GLY2020 |
| C | GLY2021 |
| C | GLY2022 |
| C | ILE2023 |
| C | SER2024 |
| C | GLU2043 |
| C | ALA2044 |
| C | ARG2045 |
| C | GLY2049 |
| C | GLY2050 |
| C | ARG2051 |
| C | GLY2066 |
| C | GLY2067 |
| C | ALA2068 |
| C | TYR2069 |
| C | PRO2243 |
| C | VAL2244 |
| site_id | AC6 |
| Number of Residues | 11 |
| Details | BINDING SITE FOR RESIDUE MLG C 2709 |
| Chain | Residue |
| C | ILE2180 |
| C | PHE2208 |
| C | GLN2215 |
| C | CYS2323 |
| C | ILE2325 |
| C | ILE2335 |
| C | THR2336 |
| C | LEU2337 |
| C | TYR2407 |
| C | TYR2444 |
| C | FAD2652 |
| site_id | AC7 |
| Number of Residues | 28 |
| Details | BINDING SITE FOR RESIDUE FAD D 3652 |
| Chain | Residue |
| D | ILE3019 |
| D | GLY3020 |
| D | GLY3022 |
| D | ILE3023 |
| D | SER3024 |
| D | GLU3043 |
| D | ALA3044 |
| D | ARG3045 |
| D | GLY3050 |
| D | ARG3051 |
| D | GLY3066 |
| D | GLY3067 |
| D | ALA3068 |
| D | TYR3069 |
| D | VAL3244 |
| D | ALA3272 |
| D | ILE3273 |
| D | TRP3397 |
| D | TYR3402 |
| D | CYS3406 |
| D | TYR3407 |
| D | GLY3434 |
| D | THR3435 |
| D | GLY3443 |
| D | TYR3444 |
| D | MET3445 |
| D | ALA3448 |
| D | MLG3709 |
| site_id | AC8 |
| Number of Residues | 11 |
| Details | BINDING SITE FOR RESIDUE MLG D 3709 |
| Chain | Residue |
| D | ILE3180 |
| D | PHE3208 |
| D | GLN3215 |
| D | CYS3323 |
| D | ILE3325 |
| D | ILE3335 |
| D | THR3336 |
| D | LEU3337 |
| D | TYR3407 |
| D | TYR3444 |
| D | FAD3652 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 1984 |
| Details | TOPO_DOM: Cytoplasmic |
| Chain | Residue | Details |
| A | MET1-SER497 | |
| B | MET1001-SER1497 | |
| C | MET2001-SER2497 | |
| D | MET3001-SER3497 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 80 |
| Details | TRANSMEM: Helical; Anchor for type IV membrane protein |
| Chain | Residue | Details |
| A | VAL498-LEU518 | |
| B | VAL1498-LEU1518 | |
| C | VAL2498-LEU2518 | |
| D | VAL3498-LEU3518 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 28 |
| Details | TOPO_DOM: Mitochondrial intermembrane |
| Chain | Residue | Details |
| A | TYR519-CYS526 | |
| B | TYR1519-CYS1526 | |
| C | TYR2519-CYS2526 | |
| D | TYR3519-CYS3526 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 4 |
| Details | SITE: Important for substrate specificity |
| Chain | Residue | Details |
| A | ILE335 | |
| B | ILE1335 | |
| C | ILE2335 | |
| D | ILE3335 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 4 |
| Details | SITE: Important for catalytic activity => ECO:0000250 |
| Chain | Residue | Details |
| A | CYS374 | |
| B | CYS1374 | |
| C | CYS2374 | |
| D | CYS3374 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 4 |
| Details | MOD_RES: N-acetylmethionine => ECO:0000250|UniProtKB:P21397 |
| Chain | Residue | Details |
| A | MET1 | |
| B | MET1001 | |
| C | MET2001 | |
| D | MET3001 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 4 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:22673903 |
| Chain | Residue | Details |
| A | SER383 | |
| B | SER1383 | |
| C | SER2383 | |
| D | SER3383 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 4 |
| Details | MOD_RES: S-8alpha-FAD cysteine |
| Chain | Residue | Details |
| A | CYS406 | |
| B | CYS1406 | |
| C | CYS2406 | |
| D | CYS3406 |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 1 |
| Details | Annotated By Reference To The Literature 1b5q |
| Chain | Residue | Details |
| A | GLY71 |
| site_id | CSA2 |
| Number of Residues | 1 |
| Details | Annotated By Reference To The Literature 1b5q |
| Chain | Residue | Details |
| B | GLY1071 |
| site_id | CSA3 |
| Number of Residues | 1 |
| Details | Annotated By Reference To The Literature 1b5q |
| Chain | Residue | Details |
| C | GLY2071 |
| site_id | CSA4 |
| Number of Residues | 1 |
| Details | Annotated By Reference To The Literature 1b5q |
| Chain | Residue | Details |
| D | GLY3071 |
