1O58

Crystal structure of O-acetylserine sulfhydrylase (TM0665) from Thermotoga maritima at 1.80 A resolution

Replaces:  1J6N

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004122	molecular_function	cystathionine beta-synthase activity
A	0004124	molecular_function	cysteine synthase activity
A	0005737	cellular_component	cytoplasm
A	0006535	biological_process	cysteine biosynthetic process from serine
A	0008652	biological_process	amino acid biosynthetic process
A	0016740	molecular_function	transferase activity
A	0016765	molecular_function	transferase activity, transferring alkyl or aryl (other than methyl) groups
A	0019344	biological_process	cysteine biosynthetic process
A	0080146	molecular_function	L-cysteine desulfhydrase activity
B	0004122	molecular_function	cystathionine beta-synthase activity
B	0004124	molecular_function	cysteine synthase activity
B	0005737	cellular_component	cytoplasm
B	0006535	biological_process	cysteine biosynthetic process from serine
B	0008652	biological_process	amino acid biosynthetic process
B	0016740	molecular_function	transferase activity
B	0016765	molecular_function	transferase activity, transferring alkyl or aryl (other than methyl) groups
B	0019344	biological_process	cysteine biosynthetic process
B	0080146	molecular_function	L-cysteine desulfhydrase activity
C	0004122	molecular_function	cystathionine beta-synthase activity
C	0004124	molecular_function	cysteine synthase activity
C	0005737	cellular_component	cytoplasm
C	0006535	biological_process	cysteine biosynthetic process from serine
C	0008652	biological_process	amino acid biosynthetic process
C	0016740	molecular_function	transferase activity
C	0016765	molecular_function	transferase activity, transferring alkyl or aryl (other than methyl) groups
C	0019344	biological_process	cysteine biosynthetic process
C	0080146	molecular_function	L-cysteine desulfhydrase activity
D	0004122	molecular_function	cystathionine beta-synthase activity
D	0004124	molecular_function	cysteine synthase activity
D	0005737	cellular_component	cytoplasm
D	0006535	biological_process	cysteine biosynthetic process from serine
D	0008652	biological_process	amino acid biosynthetic process
D	0016740	molecular_function	transferase activity
D	0016765	molecular_function	transferase activity, transferring alkyl or aryl (other than methyl) groups
D	0019344	biological_process	cysteine biosynthetic process
D	0080146	molecular_function	L-cysteine desulfhydrase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	8
Details	BINDING SITE FOR RESIDUE PO4 A 1401

Chain	Residue
A	LYS35
A	THR60
A	SER61
A	ASN63
A	MET64
A	GLN132
A	HOH1490
A	HOH1503

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site_id	AC2
Number of Residues	10
Details	BINDING SITE FOR RESIDUE PO4 A 1402

Chain	Residue
A	VAL165
A	GLY166
A	THR167
A	GLY168
A	GLY169
A	THR170
A	HOH1409
A	HOH1421
A	HOH1446
A	LYS35

---

site_id	AC3
Number of Residues	10
Details	BINDING SITE FOR RESIDUE PO4 B 1403

Chain	Residue
B	LYS35
B	GLY166
B	THR167
B	GLY168
B	GLY169
B	THR170
B	HOH1406
B	HOH1407
B	HOH1410
B	HOH1494

---

site_id	AC4
Number of Residues	8
Details	BINDING SITE FOR RESIDUE PO4 B 1404

Chain	Residue
B	LYS35
B	THR60
B	SER61
B	ASN63
B	MET64
B	GLN132
B	HOH1432
B	HOH1575

---

site_id	AC5
Number of Residues	11
Details	BINDING SITE FOR RESIDUE PO4 C 1405

Chain	Residue
C	LYS35
C	VAL165
C	GLY166
C	THR167
C	GLY168
C	GLY169
C	THR170
C	HOH1409
C	HOH1411
C	HOH1421
C	HOH1465

---

site_id	AC6
Number of Residues	8
Details	BINDING SITE FOR RESIDUE PO4 C 1406

Chain	Residue
C	LYS35
C	SER61
C	GLY62
C	ASN63
C	MET64
C	GLN132
C	HOH1457
C	HOH1501

---

site_id	AC7
Number of Residues	11
Details	BINDING SITE FOR RESIDUE PO4 D 1407

Chain	Residue
D	LYS35
D	VAL165
D	GLY166
D	THR167
D	GLY168
D	GLY169
D	THR170
D	HOH1412
D	HOH1418
D	HOH1433
D	HOH1500

---

site_id	AC8
Number of Residues	8
Details	BINDING SITE FOR RESIDUE PO4 D 1408

Chain	Residue
D	LYS35
D	THR60
D	SER61
D	ASN63
D	MET64
D	GLN132
D	HOH1512
D	HOH1538

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Functional Information from PROSITE/UniProt

site_id	PS00901
Number of Residues	19
Details	CYS_SYNTHASE Cysteine synthase/cystathionine beta-synthase P-phosphate attachment site. KlEknn.PGgSVKdRpAlfM

Chain	Residue	Details
A	LYS24-MET42

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