1NY6

Crystal structure of sigm54 activator (AAA+ ATPase) in the active state

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005524	molecular_function	ATP binding
A	0006355	biological_process	regulation of DNA-templated transcription
A	0008134	molecular_function	transcription factor binding
B	0005524	molecular_function	ATP binding
B	0006355	biological_process	regulation of DNA-templated transcription
B	0008134	molecular_function	transcription factor binding
C	0005524	molecular_function	ATP binding
C	0006355	biological_process	regulation of DNA-templated transcription
C	0008134	molecular_function	transcription factor binding
D	0005524	molecular_function	ATP binding
D	0006355	biological_process	regulation of DNA-templated transcription
D	0008134	molecular_function	transcription factor binding
E	0005524	molecular_function	ATP binding
E	0006355	biological_process	regulation of DNA-templated transcription
E	0008134	molecular_function	transcription factor binding
F	0005524	molecular_function	ATP binding
F	0006355	biological_process	regulation of DNA-templated transcription
F	0008134	molecular_function	transcription factor binding
G	0005524	molecular_function	ATP binding
G	0006355	biological_process	regulation of DNA-templated transcription
G	0008134	molecular_function	transcription factor binding
H	0005524	molecular_function	ATP binding
H	0006355	biological_process	regulation of DNA-templated transcription
H	0008134	molecular_function	transcription factor binding
I	0005524	molecular_function	ATP binding
I	0006355	biological_process	regulation of DNA-templated transcription
I	0008134	molecular_function	transcription factor binding
J	0005524	molecular_function	ATP binding
J	0006355	biological_process	regulation of DNA-templated transcription
J	0008134	molecular_function	transcription factor binding
K	0005524	molecular_function	ATP binding
K	0006355	biological_process	regulation of DNA-templated transcription
K	0008134	molecular_function	transcription factor binding
L	0005524	molecular_function	ATP binding
L	0006355	biological_process	regulation of DNA-templated transcription
L	0008134	molecular_function	transcription factor binding
M	0005524	molecular_function	ATP binding
M	0006355	biological_process	regulation of DNA-templated transcription
M	0008134	molecular_function	transcription factor binding
N	0005524	molecular_function	ATP binding
N	0006355	biological_process	regulation of DNA-templated transcription
N	0008134	molecular_function	transcription factor binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	12
Details	BINDING SITE FOR RESIDUE ADP C 1

Chain	Residue
C	VAL140
C	VAL356
C	ARG357
C	LYS360
C	GLU168
C	SER169
C	GLY170
C	VAL171
C	GLY172
C	LYS173
C	GLU174
C	VAL175

---

site_id	AC2
Number of Residues	11
Details	BINDING SITE FOR RESIDUE ADP D 2

Chain	Residue
D	TYR139
D	VAL140
D	SER169
D	GLY170
D	VAL171
D	GLY172
D	LYS173
D	GLU174
D	VAL175
D	VAL356
D	ARG357

---

site_id	AC3
Number of Residues	11
Details	BINDING SITE FOR RESIDUE ADP E 3

Chain	Residue
E	VAL140
E	GLU168
E	GLY170
E	VAL171
E	GLY172
E	LYS173
E	GLU174
E	VAL175
E	VAL356
E	ARG357
E	LYS360

---

site_id	AC4
Number of Residues	11
Details	BINDING SITE FOR RESIDUE ADP F 4

Chain	Residue
F	VAL140
F	GLY170
F	VAL171
F	GLY172
F	LYS173
F	GLU174
F	VAL175
F	LEU320
F	VAL356
F	ARG357
F	LYS360

---

site_id	AC5
Number of Residues	10
Details	BINDING SITE FOR RESIDUE ADP G 5

Chain	Residue
G	VAL140
G	SER169
G	GLY170
G	VAL171
G	GLY172
G	LYS173
G	GLU174
G	VAL175
G	VAL356
G	ARG357

---

site_id	AC6
Number of Residues	12
Details	BINDING SITE FOR RESIDUE ADP A 6

Chain	Residue
A	VAL140
A	SER169
A	GLY170
A	VAL171
A	GLY172
A	LYS173
A	GLU174
A	VAL175
A	LEU320
A	VAL356
A	ARG357
A	LYS360

---

site_id	AC7
Number of Residues	10
Details	BINDING SITE FOR RESIDUE ADP B 7

Chain	Residue
B	GLY170
B	VAL171
B	GLY172
B	LYS173
B	GLU174
B	VAL175
B	LEU320
B	VAL356
B	ARG357
B	LYS360

---

site_id	AC8
Number of Residues	14
Details	BINDING SITE FOR RESIDUE ADP I 8

Chain	Residue
I	TYR139
I	VAL140
I	PHE141
I	MET146
I	GLU168
I	GLY170
I	VAL171
I	GLY172
I	LYS173
I	GLU174
I	VAL175
I	VAL356
I	ARG357
I	LYS360

---

site_id	AC9
Number of Residues	10
Details	BINDING SITE FOR RESIDUE ADP J 9

Chain	Residue
J	ARG357
J	LYS360
J	VAL140
J	GLY170
J	VAL171
J	GLY172
J	LYS173
J	GLU174
J	VAL175
J	VAL356

---

site_id	BC1
Number of Residues	11
Details	BINDING SITE FOR RESIDUE ADP K 10

Chain	Residue
K	VAL140
K	SER169
K	GLY170
K	VAL171
K	GLY172
K	LYS173
K	GLU174
K	VAL175
K	VAL356
K	ARG357
K	LYS360

---

site_id	BC2
Number of Residues	11
Details	BINDING SITE FOR RESIDUE ADP L 11

Chain	Residue
L	VAL140
L	PHE141
L	GLY170
L	VAL171
L	GLY172
L	LYS173
L	GLU174
L	VAL175
L	VAL356
L	ARG357
L	LYS360

---

site_id	BC3
Number of Residues	12
Details	BINDING SITE FOR RESIDUE ADP M 12

Chain	Residue
M	TYR139
M	VAL140
M	PHE141
M	GLY170
M	VAL171
M	GLY172
M	LYS173
M	GLU174
M	VAL175
M	VAL356
M	ARG357
M	LYS360

---

site_id	BC4
Number of Residues	9
Details	BINDING SITE FOR RESIDUE ADP N 13

Chain	Residue
N	VAL140
N	GLU168
N	GLY170
N	VAL171
N	GLY172
N	LYS173
N	GLU174
N	VAL175
N	VAL356

---

site_id	BC5
Number of Residues	12
Details	BINDING SITE FOR RESIDUE ADP H 14

Chain	Residue
H	PHE141
H	GLU168
H	GLY170
H	VAL171
H	GLY172
H	LYS173
H	GLU174
H	VAL175
H	VAL356
H	ARG357
H	LYS360
N	GLU256

---

Functional Information from PROSITE/UniProt

site_id	PS00675
Number of Residues	14
Details	SIGMA54_INTERACT_1 Sigma-54 interaction domain ATP-binding region A signature. VLItGESGVGKevV

Chain	Residue	Details
A	VAL163-VAL176

---

site_id	PS00676
Number of Residues	16
Details	SIGMA54_INTERACT_2 Sigma-54 interaction domain ATP-binding region B signature. GfFelADGGTLFLDEI

Chain	Residue	Details
A	GLY225-ILE240

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