1NQ2

Two RTH Mutants with Impaired Hormone Binding

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003677	molecular_function	DNA binding
A	0004879	molecular_function	nuclear receptor activity
A	0006355	biological_process	regulation of DNA-templated transcription

Functional Information from PDB Data

site_id	AC1
Number of Residues	6
Details	BINDING SITE FOR RESIDUE NA A 700

Chain	Residue
A	ASP351
A	ASP351
A	HOH974
A	HOH974
A	HOH978
A	HOH978

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site_id	AC2
Number of Residues	11
Details	BINDING SITE FOR RESIDUE 4HY A 500

Chain	Residue
A	MET313
A	THR317
A	ASN331
A	LEU346
A	ILE353
A	HIS435
A	MET442
A	PHE455
A	PHE272
A	ALA279
A	ARG282

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site_id	AC3
Number of Residues	1
Details	BINDING SITE FOR RESIDUE ARS A 600

Chain	Residue
A	CYS298

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site_id	AC4
Number of Residues	1
Details	BINDING SITE FOR RESIDUE ARS A 601

Chain	Residue
A	CYS294

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site_id	AC5
Number of Residues	3
Details	BINDING SITE FOR RESIDUE ARS A 602

Chain	Residue
A	CYS388
A	ARG391
A	HOH952

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site_id	AC6
Number of Residues	2
Details	BINDING SITE FOR RESIDUE ARS A 603

Chain	Residue
A	ASP427
A	CYS434

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site_id	AC7
Number of Residues	1
Details	BINDING SITE FOR RESIDUE ARS A 604

Chain	Residue
A	CYS434

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	3
Details	Binding site: {"evidences":[{"source":"PubMed","id":"15466465","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1Y0X","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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