1NOU

Native human lysosomal beta-hexosaminidase isoform B

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0001669	cellular_component	acrosomal vesicle
A	0004553	molecular_function	hydrolase activity, hydrolyzing O-glycosyl compounds
A	0004563	molecular_function	beta-N-acetylhexosaminidase activity
A	0005515	molecular_function	protein binding
A	0005576	cellular_component	extracellular region
A	0005615	cellular_component	extracellular space
A	0005764	cellular_component	lysosome
A	0005975	biological_process	carbohydrate metabolic process
A	0006044	biological_process	N-acetylglucosamine metabolic process
A	0006491	biological_process	N-glycan processing
A	0006629	biological_process	lipid metabolic process
A	0006689	biological_process	ganglioside catabolic process
A	0007338	biological_process	single fertilization
A	0008360	biological_process	regulation of cell shape
A	0008375	molecular_function	acetylglucosaminyltransferase activity
A	0015929	molecular_function	hexosaminidase activity
A	0016020	cellular_component	membrane
A	0016231	molecular_function	beta-N-acetylglucosaminidase activity
A	0016787	molecular_function	hydrolase activity
A	0016798	molecular_function	hydrolase activity, acting on glycosyl bonds
A	0030203	biological_process	glycosaminoglycan metabolic process
A	0030207	biological_process	chondroitin sulfate proteoglycan catabolic process
A	0030209	biological_process	dermatan sulfate proteoglycan catabolic process
A	0030214	biological_process	hyaluronan catabolic process
A	0030246	molecular_function	carbohydrate binding
A	0031410	cellular_component	cytoplasmic vesicle
A	0035578	cellular_component	azurophil granule lumen
A	0042582	cellular_component	azurophil granule
A	0042802	molecular_function	identical protein binding
A	0043202	cellular_component	lysosomal lumen
A	0043615	biological_process	astrocyte cell migration
A	0044877	molecular_function	protein-containing complex binding
A	0045944	biological_process	positive regulation of transcription by RNA polymerase II
A	0060473	cellular_component	cortical granule
A	0070062	cellular_component	extracellular exosome
A	1901135	biological_process	carbohydrate derivative metabolic process
A	1905379	cellular_component	beta-N-acetylhexosaminidase complex
B	0001669	cellular_component	acrosomal vesicle
B	0004553	molecular_function	hydrolase activity, hydrolyzing O-glycosyl compounds
B	0004563	molecular_function	beta-N-acetylhexosaminidase activity
B	0005515	molecular_function	protein binding
B	0005576	cellular_component	extracellular region
B	0005615	cellular_component	extracellular space
B	0005764	cellular_component	lysosome
B	0005975	biological_process	carbohydrate metabolic process
B	0006044	biological_process	N-acetylglucosamine metabolic process
B	0006491	biological_process	N-glycan processing
B	0006629	biological_process	lipid metabolic process
B	0006689	biological_process	ganglioside catabolic process
B	0007338	biological_process	single fertilization
B	0008360	biological_process	regulation of cell shape
B	0008375	molecular_function	acetylglucosaminyltransferase activity
B	0015929	molecular_function	hexosaminidase activity
B	0016020	cellular_component	membrane
B	0016231	molecular_function	beta-N-acetylglucosaminidase activity
B	0016787	molecular_function	hydrolase activity
B	0016798	molecular_function	hydrolase activity, acting on glycosyl bonds
B	0030203	biological_process	glycosaminoglycan metabolic process
B	0030207	biological_process	chondroitin sulfate proteoglycan catabolic process
B	0030209	biological_process	dermatan sulfate proteoglycan catabolic process
B	0030214	biological_process	hyaluronan catabolic process
B	0030246	molecular_function	carbohydrate binding
B	0031410	cellular_component	cytoplasmic vesicle
B	0035578	cellular_component	azurophil granule lumen
B	0042582	cellular_component	azurophil granule
B	0042802	molecular_function	identical protein binding
B	0043202	cellular_component	lysosomal lumen
B	0043615	biological_process	astrocyte cell migration
B	0044877	molecular_function	protein-containing complex binding
B	0045944	biological_process	positive regulation of transcription by RNA polymerase II
B	0060473	cellular_component	cortical granule
B	0070062	cellular_component	extracellular exosome
B	1901135	biological_process	carbohydrate derivative metabolic process
B	1905379	cellular_component	beta-N-acetylhexosaminidase complex

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	Active site: {"description":"Proton donor","evidences":[{"source":"PubMed","id":"11329289","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	2
Details	Site: {"description":"Not glycosylated","evidences":[{"source":"PubMed","id":"11447134","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	2
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"11447134","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19159218","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	4
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"11447134","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	2
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"11447134","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"12754519","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19159218","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

Catalytic Information from CSA

site_id	CSA1
Number of Residues	2
Details	Annotated By Reference To The Literature 1qba

Chain	Residue	Details
A	ASP354
A	GLU355

---

site_id	CSA2
Number of Residues	2
Details	Annotated By Reference To The Literature 1qba

Chain	Residue	Details
B	ASP354
B	GLU355

---