1NNK

X-ray structure of the GluR2 ligand-binding core (S1S2J) in complex with (S)-ATPA at 1.85 A resolution. Crystallization with zinc ions.

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0015276	molecular_function	ligand-gated monoatomic ion channel activity
A	0016020	cellular_component	membrane

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN A 451

Chain	Residue
A	HIS20
A	GLU21
A	GLU163
A	CL453

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site_id	AC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN A 452

Chain	Residue
A	GLU27
A	GLU39
A	HIS43
A	HOH595

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site_id	AC3
Number of Residues	2
Details	BINDING SITE FOR RESIDUE CL A 453

Chain	Residue
A	ZN451
A	GLU163

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site_id	AC4
Number of Residues	15
Details	BINDING SITE FOR RESIDUE CE2 A 454

Chain	Residue
A	GLU10
A	TYR58
A	PRO86
A	LEU87
A	THR88
A	ARG93
A	GLY138
A	SER139
A	THR140
A	THR171
A	GLU190
A	MET193
A	TYR217
A	HOH455
A	HOH466

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	6
Details	BINDING: BINDING => ECO:0000269|PubMed:11086992, ECO:0000269|PubMed:16483599, ECO:0007744|PDB:1FTJ, ECO:0007744|PDB:2CMO

Chain	Residue	Details
A	PRO86
A	THR88
A	ARG93
A	SER139
A	THR140
A	GLU190

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site_id	SWS_FT_FI2
Number of Residues	3
Details	SITE: Interaction with the cone snail toxin Con-ikot-ikot => ECO:0000269|PubMed:25103405

Chain	Residue	Details
A	ARG61
A	ARG145
A	LYS237

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site_id	SWS_FT_FI3
Number of Residues	1
Details	SITE: Crucial to convey clamshell closure to channel opening => ECO:0000269|PubMed:25103405

Chain	Residue	Details
A	ILE118

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site_id	SWS_FT_FI4
Number of Residues	1
Details	MOD_RES: Phosphoserine; by PKC => ECO:0000269|PubMed:8848293

Chain	Residue	Details
A	SER147

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site_id	SWS_FT_FI5
Number of Residues	1
Details	MOD_RES: Phosphoserine; by PKG => ECO:0000269|PubMed:8848293

Chain	Residue	Details
A	SER181

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site_id	SWS_FT_FI6
Number of Residues	1
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255

Chain	Residue	Details
A	ASN0

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