1NIW

Crystal structure of endothelial nitric oxide synthase peptide bound to calmodulin

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000086	biological_process	G2/M transition of mitotic cell cycle
A	0000785	cellular_component	chromatin
A	0000922	cellular_component	spindle pole
A	0001975	biological_process	response to amphetamine
A	0002027	biological_process	regulation of heart rate
A	0005246	molecular_function	calcium channel regulator activity
A	0005509	molecular_function	calcium ion binding
A	0005513	biological_process	detection of calcium ion
A	0005515	molecular_function	protein binding
A	0005634	cellular_component	nucleus
A	0005654	cellular_component	nucleoplasm
A	0005737	cellular_component	cytoplasm
A	0005739	cellular_component	mitochondrion
A	0005813	cellular_component	centrosome
A	0005819	cellular_component	spindle
A	0005829	cellular_component	cytosol
A	0005876	cellular_component	spindle microtubule
A	0007259	biological_process	cell surface receptor signaling pathway via JAK-STAT
A	0008076	cellular_component	voltage-gated potassium channel complex
A	0008179	molecular_function	adenylate cyclase binding
A	0010856	molecular_function	adenylate cyclase activator activity
A	0010880	biological_process	regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
A	0010881	biological_process	regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
A	0016020	cellular_component	membrane
A	0016240	biological_process	autophagosome membrane docking
A	0019855	molecular_function	calcium channel inhibitor activity
A	0019901	molecular_function	protein kinase binding
A	0019904	molecular_function	protein domain specific binding
A	0030017	cellular_component	sarcomere
A	0030235	molecular_function	nitric-oxide synthase regulator activity
A	0030426	cellular_component	growth cone
A	0030672	cellular_component	synaptic vesicle membrane
A	0031432	molecular_function	titin binding
A	0031514	cellular_component	motile cilium
A	0031800	molecular_function	type 3 metabotropic glutamate receptor binding
A	0031966	cellular_component	mitochondrial membrane
A	0031982	cellular_component	vesicle
A	0032465	biological_process	regulation of cytokinesis
A	0032991	cellular_component	protein-containing complex
A	0034704	cellular_component	calcium channel complex
A	0035458	biological_process	cellular response to interferon-beta
A	0043209	cellular_component	myelin sheath
A	0043539	molecular_function	protein serine/threonine kinase activator activity
A	0043548	molecular_function	phosphatidylinositol 3-kinase binding
A	0044305	cellular_component	calyx of Held
A	0044325	molecular_function	transmembrane transporter binding
A	0046427	biological_process	positive regulation of receptor signaling pathway via JAK-STAT
A	0046872	molecular_function	metal ion binding
A	0048306	molecular_function	calcium-dependent protein binding
A	0050848	biological_process	regulation of calcium-mediated signaling
A	0050998	molecular_function	nitric-oxide synthase binding
A	0051412	biological_process	response to corticosterone
A	0051592	biological_process	response to calcium ion
A	0055117	biological_process	regulation of cardiac muscle contraction
A	0060314	biological_process	regulation of ryanodine-sensitive calcium-release channel activity
A	0060315	biological_process	negative regulation of ryanodine-sensitive calcium-release channel activity
A	0071346	biological_process	cellular response to type II interferon
A	0072542	molecular_function	protein phosphatase activator activity
A	0090150	biological_process	establishment of protein localization to membrane
A	0090151	biological_process	establishment of protein localization to mitochondrial membrane
A	0097225	cellular_component	sperm midpiece
A	0097720	biological_process	calcineurin-mediated signaling
A	0098685	cellular_component	Schaffer collateral - CA1 synapse
A	0098901	biological_process	regulation of cardiac muscle cell action potential
A	0099523	cellular_component	presynaptic cytosol
A	0099524	cellular_component	postsynaptic cytosol
A	0140056	biological_process	organelle localization by membrane tethering
A	0140238	biological_process	presynaptic endocytosis
A	0141110	molecular_function	transporter inhibitor activity
A	1900242	biological_process	regulation of synaptic vesicle endocytosis
A	1901844	biological_process	regulation of cell communication by electrical coupling involved in cardiac conduction
A	1902494	cellular_component	catalytic complex
A	1905913	biological_process	negative regulation of calcium ion export across plasma membrane
A	1990456	biological_process	mitochondrion-endoplasmic reticulum membrane tethering
A	2000300	biological_process	regulation of synaptic vesicle exocytosis
C	0000086	biological_process	G2/M transition of mitotic cell cycle
C	0000785	cellular_component	chromatin
C	0000922	cellular_component	spindle pole
C	0001975	biological_process	response to amphetamine
C	0002027	biological_process	regulation of heart rate
C	0005246	molecular_function	calcium channel regulator activity
C	0005509	molecular_function	calcium ion binding
C	0005513	biological_process	detection of calcium ion
C	0005515	molecular_function	protein binding
C	0005634	cellular_component	nucleus
C	0005654	cellular_component	nucleoplasm
C	0005737	cellular_component	cytoplasm
C	0005739	cellular_component	mitochondrion
C	0005813	cellular_component	centrosome
C	0005819	cellular_component	spindle
C	0005829	cellular_component	cytosol
C	0005876	cellular_component	spindle microtubule
C	0007259	biological_process	cell surface receptor signaling pathway via JAK-STAT
C	0008076	cellular_component	voltage-gated potassium channel complex
C	0008179	molecular_function	adenylate cyclase binding
C	0010856	molecular_function	adenylate cyclase activator activity
C	0010880	biological_process	regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
C	0010881	biological_process	regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
C	0016020	cellular_component	membrane
C	0016240	biological_process	autophagosome membrane docking
C	0019855	molecular_function	calcium channel inhibitor activity
C	0019901	molecular_function	protein kinase binding
C	0019904	molecular_function	protein domain specific binding
C	0030017	cellular_component	sarcomere
C	0030235	molecular_function	nitric-oxide synthase regulator activity
C	0030426	cellular_component	growth cone
C	0030672	cellular_component	synaptic vesicle membrane
C	0031432	molecular_function	titin binding
C	0031514	cellular_component	motile cilium
C	0031800	molecular_function	type 3 metabotropic glutamate receptor binding
C	0031966	cellular_component	mitochondrial membrane
C	0031982	cellular_component	vesicle
C	0032465	biological_process	regulation of cytokinesis
C	0032991	cellular_component	protein-containing complex
C	0034704	cellular_component	calcium channel complex
C	0035458	biological_process	cellular response to interferon-beta
C	0043209	cellular_component	myelin sheath
C	0043539	molecular_function	protein serine/threonine kinase activator activity
C	0043548	molecular_function	phosphatidylinositol 3-kinase binding
C	0044305	cellular_component	calyx of Held
C	0044325	molecular_function	transmembrane transporter binding
C	0046427	biological_process	positive regulation of receptor signaling pathway via JAK-STAT
C	0046872	molecular_function	metal ion binding
C	0048306	molecular_function	calcium-dependent protein binding
C	0050848	biological_process	regulation of calcium-mediated signaling
C	0050998	molecular_function	nitric-oxide synthase binding
C	0051412	biological_process	response to corticosterone
C	0051592	biological_process	response to calcium ion
C	0055117	biological_process	regulation of cardiac muscle contraction
C	0060314	biological_process	regulation of ryanodine-sensitive calcium-release channel activity
C	0060315	biological_process	negative regulation of ryanodine-sensitive calcium-release channel activity
C	0071346	biological_process	cellular response to type II interferon
C	0072542	molecular_function	protein phosphatase activator activity
C	0090150	biological_process	establishment of protein localization to membrane
C	0090151	biological_process	establishment of protein localization to mitochondrial membrane
C	0097225	cellular_component	sperm midpiece
C	0097720	biological_process	calcineurin-mediated signaling
C	0098685	cellular_component	Schaffer collateral - CA1 synapse
C	0098901	biological_process	regulation of cardiac muscle cell action potential
C	0099523	cellular_component	presynaptic cytosol
C	0099524	cellular_component	postsynaptic cytosol
C	0140056	biological_process	organelle localization by membrane tethering
C	0140238	biological_process	presynaptic endocytosis
C	0141110	molecular_function	transporter inhibitor activity
C	1900242	biological_process	regulation of synaptic vesicle endocytosis
C	1901844	biological_process	regulation of cell communication by electrical coupling involved in cardiac conduction
C	1902494	cellular_component	catalytic complex
C	1905913	biological_process	negative regulation of calcium ion export across plasma membrane
C	1990456	biological_process	mitochondrion-endoplasmic reticulum membrane tethering
C	2000300	biological_process	regulation of synaptic vesicle exocytosis
E	0000086	biological_process	G2/M transition of mitotic cell cycle
E	0000785	cellular_component	chromatin
E	0000922	cellular_component	spindle pole
E	0001975	biological_process	response to amphetamine
E	0002027	biological_process	regulation of heart rate
E	0005246	molecular_function	calcium channel regulator activity
E	0005509	molecular_function	calcium ion binding
E	0005513	biological_process	detection of calcium ion
E	0005515	molecular_function	protein binding
E	0005634	cellular_component	nucleus
E	0005654	cellular_component	nucleoplasm
E	0005737	cellular_component	cytoplasm
E	0005739	cellular_component	mitochondrion
E	0005813	cellular_component	centrosome
E	0005819	cellular_component	spindle
E	0005829	cellular_component	cytosol
E	0005876	cellular_component	spindle microtubule
E	0007259	biological_process	cell surface receptor signaling pathway via JAK-STAT
E	0008076	cellular_component	voltage-gated potassium channel complex
E	0008179	molecular_function	adenylate cyclase binding
E	0010856	molecular_function	adenylate cyclase activator activity
E	0010880	biological_process	regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
E	0010881	biological_process	regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
E	0016020	cellular_component	membrane
E	0016240	biological_process	autophagosome membrane docking
E	0019855	molecular_function	calcium channel inhibitor activity
E	0019901	molecular_function	protein kinase binding
E	0019904	molecular_function	protein domain specific binding
E	0030017	cellular_component	sarcomere
E	0030235	molecular_function	nitric-oxide synthase regulator activity
E	0030426	cellular_component	growth cone
E	0030672	cellular_component	synaptic vesicle membrane
E	0031432	molecular_function	titin binding
E	0031514	cellular_component	motile cilium
E	0031800	molecular_function	type 3 metabotropic glutamate receptor binding
E	0031966	cellular_component	mitochondrial membrane
E	0031982	cellular_component	vesicle
E	0032465	biological_process	regulation of cytokinesis
E	0032991	cellular_component	protein-containing complex
E	0034704	cellular_component	calcium channel complex
E	0035458	biological_process	cellular response to interferon-beta
E	0043209	cellular_component	myelin sheath
E	0043539	molecular_function	protein serine/threonine kinase activator activity
E	0043548	molecular_function	phosphatidylinositol 3-kinase binding
E	0044305	cellular_component	calyx of Held
E	0044325	molecular_function	transmembrane transporter binding
E	0046427	biological_process	positive regulation of receptor signaling pathway via JAK-STAT
E	0046872	molecular_function	metal ion binding
E	0048306	molecular_function	calcium-dependent protein binding
E	0050848	biological_process	regulation of calcium-mediated signaling
E	0050998	molecular_function	nitric-oxide synthase binding
E	0051412	biological_process	response to corticosterone
E	0051592	biological_process	response to calcium ion
E	0055117	biological_process	regulation of cardiac muscle contraction
E	0060314	biological_process	regulation of ryanodine-sensitive calcium-release channel activity
E	0060315	biological_process	negative regulation of ryanodine-sensitive calcium-release channel activity
E	0071346	biological_process	cellular response to type II interferon
E	0072542	molecular_function	protein phosphatase activator activity
E	0090150	biological_process	establishment of protein localization to membrane
E	0090151	biological_process	establishment of protein localization to mitochondrial membrane
E	0097225	cellular_component	sperm midpiece
E	0097720	biological_process	calcineurin-mediated signaling
E	0098685	cellular_component	Schaffer collateral - CA1 synapse
E	0098901	biological_process	regulation of cardiac muscle cell action potential
E	0099523	cellular_component	presynaptic cytosol
E	0099524	cellular_component	postsynaptic cytosol
E	0140056	biological_process	organelle localization by membrane tethering
E	0140238	biological_process	presynaptic endocytosis
E	0141110	molecular_function	transporter inhibitor activity
E	1900242	biological_process	regulation of synaptic vesicle endocytosis
E	1901844	biological_process	regulation of cell communication by electrical coupling involved in cardiac conduction
E	1902494	cellular_component	catalytic complex
E	1905913	biological_process	negative regulation of calcium ion export across plasma membrane
E	1990456	biological_process	mitochondrion-endoplasmic reticulum membrane tethering
E	2000300	biological_process	regulation of synaptic vesicle exocytosis
G	0000086	biological_process	G2/M transition of mitotic cell cycle
G	0000785	cellular_component	chromatin
G	0000922	cellular_component	spindle pole
G	0001975	biological_process	response to amphetamine
G	0002027	biological_process	regulation of heart rate
G	0005246	molecular_function	calcium channel regulator activity
G	0005509	molecular_function	calcium ion binding
G	0005513	biological_process	detection of calcium ion
G	0005515	molecular_function	protein binding
G	0005634	cellular_component	nucleus
G	0005654	cellular_component	nucleoplasm
G	0005737	cellular_component	cytoplasm
G	0005739	cellular_component	mitochondrion
G	0005813	cellular_component	centrosome
G	0005819	cellular_component	spindle
G	0005829	cellular_component	cytosol
G	0005876	cellular_component	spindle microtubule
G	0007259	biological_process	cell surface receptor signaling pathway via JAK-STAT
G	0008076	cellular_component	voltage-gated potassium channel complex
G	0008179	molecular_function	adenylate cyclase binding
G	0010856	molecular_function	adenylate cyclase activator activity
G	0010880	biological_process	regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
G	0010881	biological_process	regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
G	0016020	cellular_component	membrane
G	0016240	biological_process	autophagosome membrane docking
G	0019855	molecular_function	calcium channel inhibitor activity
G	0019901	molecular_function	protein kinase binding
G	0019904	molecular_function	protein domain specific binding
G	0030017	cellular_component	sarcomere
G	0030235	molecular_function	nitric-oxide synthase regulator activity
G	0030426	cellular_component	growth cone
G	0030672	cellular_component	synaptic vesicle membrane
G	0031432	molecular_function	titin binding
G	0031514	cellular_component	motile cilium
G	0031800	molecular_function	type 3 metabotropic glutamate receptor binding
G	0031966	cellular_component	mitochondrial membrane
G	0031982	cellular_component	vesicle
G	0032465	biological_process	regulation of cytokinesis
G	0032991	cellular_component	protein-containing complex
G	0034704	cellular_component	calcium channel complex
G	0035458	biological_process	cellular response to interferon-beta
G	0043209	cellular_component	myelin sheath
G	0043539	molecular_function	protein serine/threonine kinase activator activity
G	0043548	molecular_function	phosphatidylinositol 3-kinase binding
G	0044305	cellular_component	calyx of Held
G	0044325	molecular_function	transmembrane transporter binding
G	0046427	biological_process	positive regulation of receptor signaling pathway via JAK-STAT
G	0046872	molecular_function	metal ion binding
G	0048306	molecular_function	calcium-dependent protein binding
G	0050848	biological_process	regulation of calcium-mediated signaling
G	0050998	molecular_function	nitric-oxide synthase binding
G	0051412	biological_process	response to corticosterone
G	0051592	biological_process	response to calcium ion
G	0055117	biological_process	regulation of cardiac muscle contraction
G	0060314	biological_process	regulation of ryanodine-sensitive calcium-release channel activity
G	0060315	biological_process	negative regulation of ryanodine-sensitive calcium-release channel activity
G	0071346	biological_process	cellular response to type II interferon
G	0072542	molecular_function	protein phosphatase activator activity
G	0090150	biological_process	establishment of protein localization to membrane
G	0090151	biological_process	establishment of protein localization to mitochondrial membrane
G	0097225	cellular_component	sperm midpiece
G	0097720	biological_process	calcineurin-mediated signaling
G	0098685	cellular_component	Schaffer collateral - CA1 synapse
G	0098901	biological_process	regulation of cardiac muscle cell action potential
G	0099523	cellular_component	presynaptic cytosol
G	0099524	cellular_component	postsynaptic cytosol
G	0140056	biological_process	organelle localization by membrane tethering
G	0140238	biological_process	presynaptic endocytosis
G	0141110	molecular_function	transporter inhibitor activity
G	1900242	biological_process	regulation of synaptic vesicle endocytosis
G	1901844	biological_process	regulation of cell communication by electrical coupling involved in cardiac conduction
G	1902494	cellular_component	catalytic complex
G	1905913	biological_process	negative regulation of calcium ion export across plasma membrane
G	1990456	biological_process	mitochondrion-endoplasmic reticulum membrane tethering
G	2000300	biological_process	regulation of synaptic vesicle exocytosis

Functional Information from PDB Data

site_id	AC1
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA A 1001

Chain	Residue
A	ASP20
A	ASP22
A	ASP24
A	THR26
A	GLU31
A	HOH3002

---

site_id	AC2
Number of Residues	5
Details	BINDING SITE FOR RESIDUE CA A 1002

Chain	Residue
A	THR62
A	GLU67
A	ASP56
A	ASP58
A	ASN60

---

site_id	AC3
Number of Residues	5
Details	BINDING SITE FOR RESIDUE CA A 1003

Chain	Residue
A	ASP93
A	ASP95
A	ASN97
A	TYR99
A	GLU104

---

site_id	AC4
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA A 1004

Chain	Residue
A	ASP129
A	ASP131
A	ASP133
A	GLN135
A	GLU140
A	HOH3014

---

site_id	AC5
Number of Residues	5
Details	BINDING SITE FOR RESIDUE CA C 1005

Chain	Residue
C	ASP20
C	ASP22
C	ASP24
C	THR26
C	GLU31

---

site_id	AC6
Number of Residues	5
Details	BINDING SITE FOR RESIDUE CA C 1006

Chain	Residue
C	ASP56
C	ASP58
C	ASN60
C	THR62
C	GLU67

---

site_id	AC7
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA C 1007

Chain	Residue
C	ASP93
C	ASP95
C	ASN97
C	TYR99
C	GLU104
C	HOH3021

---

site_id	AC8
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA C 1008

Chain	Residue
C	ASP129
C	ASP131
C	ASP133
C	GLN135
C	GLU140
C	HOH3030

---

site_id	AC9
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA E 1009

Chain	Residue
E	ASP20
E	ASP22
E	ASP24
E	THR26
E	GLU31
E	HOH3031

---

site_id	BC1
Number of Residues	5
Details	BINDING SITE FOR RESIDUE CA E 1010

Chain	Residue
E	ASP56
E	ASP58
E	ASN60
E	THR62
E	GLU67

---

site_id	BC2
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA E 1011

Chain	Residue
E	ASP93
E	ASP95
E	ASN97
E	TYR99
E	GLU104
E	HOH3033

---

site_id	BC3
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA E 1012

Chain	Residue
E	ASP129
E	ASP131
E	ASP133
E	GLN135
E	GLU140
E	HOH3044

---

site_id	BC4
Number of Residues	6
Details	BINDING SITE FOR RESIDUE SO4 A 4001

Chain	Residue
A	SER101
A	ALA103
A	GLU104
A	HOH3171
E	ALA102
E	ARG106

---

site_id	BC5
Number of Residues	5
Details	BINDING SITE FOR RESIDUE CA G 1013

Chain	Residue
G	ASP20
G	ASP22
G	ASP24
G	THR26
G	GLU31

---

site_id	BC6
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA G 1014

Chain	Residue
G	ASP56
G	ASP58
G	ASN60
G	THR62
G	GLU67
G	HOH3046

---

site_id	BC7
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA G 1015

Chain	Residue
G	ASP93
G	ASP95
G	ASN97
G	TYR99
G	GLU104
G	HOH3048

---

site_id	BC8
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA G 1016

Chain	Residue
G	ASP129
G	ASP131
G	ASP133
G	GLN135
G	GLU140
G	HOH3241

---

site_id	BC9
Number of Residues	6
Details	BINDING SITE FOR RESIDUE EDO C 5001

Chain	Residue
C	TYR138
C	HOH3069
C	HOH3102
A	HOH3015
C	GLY98
C	ASN137

---

site_id	CC1
Number of Residues	3
Details	BINDING SITE FOR RESIDUE EDO C 5002

Chain	Residue
C	ARG126
C	GLU127
C	ILE130

---

site_id	CC2
Number of Residues	3
Details	BINDING SITE FOR RESIDUE EDO E 5003

Chain	Residue
E	LEU39
E	GLU87
E	ARG90

---

site_id	CC3
Number of Residues	5
Details	BINDING SITE FOR RESIDUE EDO E 5004

Chain	Residue
E	GLY98
E	TYR99
E	ASN137
E	TYR138
E	HOH3154

---

Functional Information from PROSITE/UniProt

site_id	PS00018
Number of Residues	13
Details	EF_HAND_1 EF-hand calcium-binding domain. DKDGDGTITtkEL

Chain	Residue	Details
A	ASP20-LEU32
A	ASP56-PHE68
A	ASP93-LEU105
A	ASP129-PHE141

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	20
Details	Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00448","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"11323678","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"23109337","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"3145979","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1G4Y","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1NIW","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2HQW","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2YGG","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3B32","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3BXK","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3BXL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3CLN","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3IFK","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3SJQ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4EHQ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4G27","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4G28","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4I2Y","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4J9Y","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4J9Z","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4QNH","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	20
Details	Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00448","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"11323678","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"23109337","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"3145979","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1G4Y","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1NIW","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2HQW","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2YGG","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3B32","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3BXK","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3BXL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3CLN","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3EK4","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3EK7","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3EK8","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3EKH","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3EVR","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3EVU","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3IFK","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3SG2","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3SG3","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3SG4","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3SG5","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3SG6","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3SG7","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3SJQ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3WLC","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3WLD","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4EHQ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4G27","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4G28","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4I2Y","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4J9Y","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4J9Z","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4QNH","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	20
Details	Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00448","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"23109337","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"3145979","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1NIW","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2HQW","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2YGG","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3BXK","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3BXL","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3CLN","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3EK4","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3EK7","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3EK8","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3EKH","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3EVR","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3EVU","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3SG2","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3SG3","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3SG4","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3SG5","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3SG6","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3SG7","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3SJQ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3WLC","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3WLD","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4EHQ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4I2Y","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4RJD","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	4
Details	Modified residue: {"description":"N6-acetyllysine; alternate","evidences":[{"source":"UniProtKB","id":"P0DP23","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	4
Details	Modified residue: {"description":"Phosphothreonine; by CaMK4","evidences":[{"source":"PubMed","id":"12392717","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	4
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"P0DP23","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	4
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"UniProtKB","id":"P0DP23","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	4
Details	Modified residue: {"description":"Phosphotyrosine","evidences":[{"source":"PubMed","id":"22673903","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI9
Number of Residues	4
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"22673903","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI10
Number of Residues	4
Details	Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"UniProtKB","id":"P0DP23","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI11
Number of Residues	4
Details	Modified residue: {"description":"N6-methyllysine; alternate","evidences":[{"source":"UniProtKB","id":"P0DP23","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI12
Number of Residues	8
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin); alternate","evidences":[{"source":"UniProtKB","id":"P62157","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI13
Number of Residues	4
Details	Modified residue: {"description":"Phosphothreonine; by AMPK","evidences":[{"source":"PubMed","id":"16126727","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

Catalytic Information from CSA

site_id	MCSA1
Number of Residues
Details	M-CSA 935

Chain

Residue

Details

---

site_id	MCSA2
Number of Residues
Details	M-CSA 935

Chain

Residue

Details

---

site_id	MCSA3
Number of Residues
Details	M-CSA 935

Chain

Residue

Details

---

site_id	MCSA4
Number of Residues
Details	M-CSA 935

Chain

Residue

Details

---