1NI2

Structure of the active FERM domain of Ezrin

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003779	molecular_function	actin binding
A	0008092	molecular_function	cytoskeletal protein binding
B	0003779	molecular_function	actin binding
B	0008092	molecular_function	cytoskeletal protein binding

Functional Information from PROSITE/UniProt

site_id	PS00660
Number of Residues	31
Details	FERM_1 FERM domain signature 1. WLkldKkVsaQe.Vrkenplq.FkfrakFYpeD

Chain	Residue	Details
A	TRP58-ASP88

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site_id	PS00661
Number of Residues	30
Details	FERM_2 FERM domain signature 2. HaehrgmlkdNAmleYLki.AqdLemYGiNY

Chain	Residue	Details
A	HIS176-TYR205

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	588
Details	Domain: {"description":"FERM","evidences":[{"source":"PROSITE-ProRule","id":"PRU00084","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	10
Details	Motif: {"description":"[IL]-x-C-x-x-[DE] motif","evidences":[{"source":"PubMed","id":"25417112","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI3
Number of Residues	2
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"19608861","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI4
Number of Residues	2
Details	Modified residue: {"description":"Phosphotyrosine; by PDGFR","evidences":[{"source":"PubMed","id":"1382070","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"18046454","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

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