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1NF3

Structure of Cdc42 in a complex with the GTPase-binding domain of the cell polarity protein, Par6

Functional Information from GO Data
ChainGOidnamespacecontents
A0000139cellular_componentGolgi membrane
A0000322cellular_componentstorage vacuole
A0002040biological_processsprouting angiogenesis
A0003015biological_processheart process
A0003161biological_processcardiac conduction system development
A0003253biological_processcardiac neural crest cell migration involved in outflow tract morphogenesis
A0003924molecular_functionGTPase activity
A0003925molecular_functionG protein activity
A0005515molecular_functionprotein binding
A0005525molecular_functionGTP binding
A0005737cellular_componentcytoplasm
A0005789cellular_componentendoplasmic reticulum membrane
A0005813cellular_componentcentrosome
A0005819cellular_componentspindle
A0005829cellular_componentcytosol
A0005856cellular_componentcytoskeleton
A0005886cellular_componentplasma membrane
A0005911cellular_componentcell-cell junction
A0005925cellular_componentfocal adhesion
A0006897biological_processendocytosis
A0006911biological_processphagocytosis, engulfment
A0007015biological_processactin filament organization
A0007030biological_processGolgi organization
A0007088biological_processregulation of mitotic nuclear division
A0007097biological_processnuclear migration
A0007163biological_processestablishment or maintenance of cell polarity
A0007229biological_processintegrin-mediated signaling pathway
A0007264biological_processsmall GTPase-mediated signal transduction
A0007399biological_processnervous system development
A0008104biological_processprotein localization
A0009653biological_processanatomical structure morphogenesis
A0010591biological_processregulation of lamellipodium assembly
A0010592biological_processpositive regulation of lamellipodium assembly
A0016020cellular_componentmembrane
A0016787molecular_functionhydrolase activity
A0017119cellular_componentGolgi transport complex
A0019901molecular_functionprotein kinase binding
A0021762biological_processsubstantia nigra development
A0030036biological_processactin cytoskeleton organization
A0030141cellular_componentsecretory granule
A0030154biological_processcell differentiation
A0030175cellular_componentfilopodium
A0030225biological_processmacrophage differentiation
A0030307biological_processpositive regulation of cell growth
A0030335biological_processpositive regulation of cell migration
A0030425cellular_componentdendrite
A0030496cellular_componentmidbody
A0030742molecular_functionGTP-dependent protein binding
A0031252cellular_componentcell leading edge
A0031256cellular_componentleading edge membrane
A0031274biological_processpositive regulation of pseudopodium assembly
A0031333biological_processnegative regulation of protein-containing complex assembly
A0031435molecular_functionmitogen-activated protein kinase kinase kinase binding
A0031996molecular_functionthioesterase binding
A0032427molecular_functionGBD domain binding
A0032467biological_processpositive regulation of cytokinesis
A0032488biological_processCdc42 protein signal transduction
A0032956biological_processregulation of actin cytoskeleton organization
A0032991cellular_componentprotein-containing complex
A0034191molecular_functionapolipoprotein A-I receptor binding
A0034329biological_processcell junction assembly
A0034332biological_processadherens junction organization
A0035050biological_processembryonic heart tube development
A0035088biological_processestablishment or maintenance of apical/basal cell polarity
A0036336biological_processdendritic cell migration
A0036464cellular_componentcytoplasmic ribonucleoprotein granule
A0038189biological_processneuropilin signaling pathway
A0042802molecular_functionidentical protein binding
A0042995cellular_componentcell projection
A0043005cellular_componentneuron projection
A0043025cellular_componentneuronal cell body
A0043197cellular_componentdendritic spine
A0043227cellular_componentmembrane-bounded organelle
A0043410biological_processpositive regulation of MAPK cascade
A0043525biological_processpositive regulation of neuron apoptotic process
A0044788biological_processmodulation by host of viral process
A0045177cellular_componentapical part of cell
A0045198biological_processestablishment of epithelial cell apical/basal polarity
A0045335cellular_componentphagocytic vesicle
A0045740biological_processpositive regulation of DNA replication
A0046330biological_processpositive regulation of JNK cascade
A0046847biological_processfilopodium assembly
A0048549biological_processpositive regulation of pinocytosis
A0048664biological_processneuron fate determination
A0051130biological_processpositive regulation of cellular component organization
A0051233cellular_componentspindle midzone
A0051489biological_processregulation of filopodium assembly
A0051491biological_processpositive regulation of filopodium assembly
A0051492biological_processregulation of stress fiber assembly
A0051496biological_processpositive regulation of stress fiber assembly
A0051647biological_processnucleus localization
A0051649biological_processestablishment of localization in cell
A0051683biological_processestablishment of Golgi localization
A0051835biological_processpositive regulation of synapse structural plasticity
A0051897biological_processpositive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
A0051988biological_processregulation of attachment of spindle microtubules to kinetochore
A0060047biological_processheart contraction
A0060071biological_processWnt signaling pathway, planar cell polarity pathway
A0060501biological_processpositive regulation of epithelial cell proliferation involved in lung morphogenesis
A0060661biological_processsubmandibular salivary gland formation
A0060997biological_processdendritic spine morphogenesis
A0061630molecular_functionubiquitin protein ligase activity
A0070062cellular_componentextracellular exosome
A0071346biological_processcellular response to type II interferon
A0071944cellular_componentcell periphery
A0072384biological_processorganelle transport along microtubule
A0072686cellular_componentmitotic spindle
A0086101biological_processendothelin receptor signaling pathway involved in heart process
A0090135biological_processactin filament branching
A0090316biological_processpositive regulation of intracellular protein transport
A0098685cellular_componentSchaffer collateral - CA1 synapse
A0098978cellular_componentglutamatergic synapse
A0099159biological_processregulation of modification of postsynaptic structure
A0099175biological_processregulation of postsynapse organization
A0099563biological_processmodification of synaptic structure
A1900026biological_processpositive regulation of substrate adhesion-dependent cell spreading
B0000139cellular_componentGolgi membrane
B0000322cellular_componentstorage vacuole
B0002040biological_processsprouting angiogenesis
B0003015biological_processheart process
B0003161biological_processcardiac conduction system development
B0003253biological_processcardiac neural crest cell migration involved in outflow tract morphogenesis
B0003924molecular_functionGTPase activity
B0003925molecular_functionG protein activity
B0005515molecular_functionprotein binding
B0005525molecular_functionGTP binding
B0005737cellular_componentcytoplasm
B0005789cellular_componentendoplasmic reticulum membrane
B0005813cellular_componentcentrosome
B0005819cellular_componentspindle
B0005829cellular_componentcytosol
B0005856cellular_componentcytoskeleton
B0005886cellular_componentplasma membrane
B0005911cellular_componentcell-cell junction
B0005925cellular_componentfocal adhesion
B0006897biological_processendocytosis
B0006911biological_processphagocytosis, engulfment
B0007015biological_processactin filament organization
B0007030biological_processGolgi organization
B0007088biological_processregulation of mitotic nuclear division
B0007097biological_processnuclear migration
B0007163biological_processestablishment or maintenance of cell polarity
B0007229biological_processintegrin-mediated signaling pathway
B0007264biological_processsmall GTPase-mediated signal transduction
B0007399biological_processnervous system development
B0008104biological_processprotein localization
B0009653biological_processanatomical structure morphogenesis
B0010591biological_processregulation of lamellipodium assembly
B0010592biological_processpositive regulation of lamellipodium assembly
B0016020cellular_componentmembrane
B0016787molecular_functionhydrolase activity
B0017119cellular_componentGolgi transport complex
B0019901molecular_functionprotein kinase binding
B0021762biological_processsubstantia nigra development
B0030036biological_processactin cytoskeleton organization
B0030141cellular_componentsecretory granule
B0030154biological_processcell differentiation
B0030175cellular_componentfilopodium
B0030225biological_processmacrophage differentiation
B0030307biological_processpositive regulation of cell growth
B0030335biological_processpositive regulation of cell migration
B0030425cellular_componentdendrite
B0030496cellular_componentmidbody
B0030742molecular_functionGTP-dependent protein binding
B0031252cellular_componentcell leading edge
B0031256cellular_componentleading edge membrane
B0031274biological_processpositive regulation of pseudopodium assembly
B0031333biological_processnegative regulation of protein-containing complex assembly
B0031435molecular_functionmitogen-activated protein kinase kinase kinase binding
B0031996molecular_functionthioesterase binding
B0032427molecular_functionGBD domain binding
B0032467biological_processpositive regulation of cytokinesis
B0032488biological_processCdc42 protein signal transduction
B0032956biological_processregulation of actin cytoskeleton organization
B0032991cellular_componentprotein-containing complex
B0034191molecular_functionapolipoprotein A-I receptor binding
B0034329biological_processcell junction assembly
B0034332biological_processadherens junction organization
B0035050biological_processembryonic heart tube development
B0035088biological_processestablishment or maintenance of apical/basal cell polarity
B0036336biological_processdendritic cell migration
B0036464cellular_componentcytoplasmic ribonucleoprotein granule
B0038189biological_processneuropilin signaling pathway
B0042802molecular_functionidentical protein binding
B0042995cellular_componentcell projection
B0043005cellular_componentneuron projection
B0043025cellular_componentneuronal cell body
B0043197cellular_componentdendritic spine
B0043227cellular_componentmembrane-bounded organelle
B0043410biological_processpositive regulation of MAPK cascade
B0043525biological_processpositive regulation of neuron apoptotic process
B0044788biological_processmodulation by host of viral process
B0045177cellular_componentapical part of cell
B0045198biological_processestablishment of epithelial cell apical/basal polarity
B0045335cellular_componentphagocytic vesicle
B0045740biological_processpositive regulation of DNA replication
B0046330biological_processpositive regulation of JNK cascade
B0046847biological_processfilopodium assembly
B0048549biological_processpositive regulation of pinocytosis
B0048664biological_processneuron fate determination
B0051130biological_processpositive regulation of cellular component organization
B0051233cellular_componentspindle midzone
B0051489biological_processregulation of filopodium assembly
B0051491biological_processpositive regulation of filopodium assembly
B0051492biological_processregulation of stress fiber assembly
B0051496biological_processpositive regulation of stress fiber assembly
B0051647biological_processnucleus localization
B0051649biological_processestablishment of localization in cell
B0051683biological_processestablishment of Golgi localization
B0051835biological_processpositive regulation of synapse structural plasticity
B0051897biological_processpositive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
B0051988biological_processregulation of attachment of spindle microtubules to kinetochore
B0060047biological_processheart contraction
B0060071biological_processWnt signaling pathway, planar cell polarity pathway
B0060501biological_processpositive regulation of epithelial cell proliferation involved in lung morphogenesis
B0060661biological_processsubmandibular salivary gland formation
B0060997biological_processdendritic spine morphogenesis
B0061630molecular_functionubiquitin protein ligase activity
B0070062cellular_componentextracellular exosome
B0071346biological_processcellular response to type II interferon
B0071944cellular_componentcell periphery
B0072384biological_processorganelle transport along microtubule
B0072686cellular_componentmitotic spindle
B0086101biological_processendothelin receptor signaling pathway involved in heart process
B0090135biological_processactin filament branching
B0090316biological_processpositive regulation of intracellular protein transport
B0098685cellular_componentSchaffer collateral - CA1 synapse
B0098978cellular_componentglutamatergic synapse
B0099159biological_processregulation of modification of postsynaptic structure
B0099175biological_processregulation of postsynapse organization
B0099563biological_processmodification of synaptic structure
B1900026biological_processpositive regulation of substrate adhesion-dependent cell spreading
Functional Information from PDB Data
site_idAC1
Number of Residues5
DetailsBINDING SITE FOR RESIDUE MG A 201
ChainResidue
ATHR17
ATHR35
AGNP200
AHOH500
AHOH501

site_idAC2
Number of Residues5
DetailsBINDING SITE FOR RESIDUE MG B 203
ChainResidue
BHOH503
BTHR17
BTHR35
BGNP202
BHOH502

site_idAC3
Number of Residues25
DetailsBINDING SITE FOR RESIDUE GNP A 200
ChainResidue
AGLY12
AALA13
AVAL14
AGLY15
ALYS16
ATHR17
ACYS18
APHE28
ATYR32
APRO34
ATHR35
AGLY60
AGLN116
AASP118
ALEU119
ASER158
AALA159
ALEU160
AMG201
AHOH500
AHOH501
AHOH511
AHOH534
AHOH617
AHOH805

site_idAC4
Number of Residues26
DetailsBINDING SITE FOR RESIDUE GNP B 202
ChainResidue
BASP11
BGLY12
BALA13
BVAL14
BGLY15
BLYS16
BTHR17
BCYS18
BPHE28
BSER30
BTYR32
BPRO34
BTHR35
BGLY60
BGLN116
BASP118
BLEU119
BSER158
BALA159
BLEU160
BMG203
BHOH502
BHOH503
BHOH510
BHOH557
BHOH580

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues4
DetailsBINDING:
ChainResidueDetails
AGLY10
ATHR115
BGLY10
BTHR115

site_idSWS_FT_FI2
Number of Residues2
DetailsBINDING: BINDING => ECO:0000250
ChainResidueDetails
AASP57
BASP57

site_idSWS_FT_FI3
Number of Residues2
DetailsMOD_RES: (Microbial infection) O-AMP-tyrosine; by Haemophilus IbpA; alternate => ECO:0000269|PubMed:19362538, ECO:0000269|PubMed:20622875
ChainResidueDetails
ATYR32
BTYR32

site_idSWS_FT_FI4
Number of Residues2
DetailsMOD_RES: (Microbial infection) O-AMP-threonine; by Vibrio VopS => ECO:0000269|PubMed:19039103
ChainResidueDetails
ATHR35
BTHR35

site_idSWS_FT_FI5
Number of Residues2
DetailsMOD_RES: Phosphotyrosine; by SRC => ECO:0000269|PubMed:14506284
ChainResidueDetails
ATYR64
BTYR64

site_idSWS_FT_FI6
Number of Residues2
DetailsCARBOHYD: (Microbial infection) O-linked (GlcNAc) tyrosine; by Photorhabdus PAU_02230; alternate => ECO:0000269|PubMed:24141704
ChainResidueDetails
ATYR32
BTYR32

site_idSWS_FT_FI7
Number of Residues2
DetailsCARBOHYD: (Microbial infection) O-linked (Glc) threonine; by C.difficile toxins TcdA and TcdB; alternate => ECO:0000269|PubMed:24905543, ECO:0000269|PubMed:7775453, ECO:0000269|PubMed:7777059
ChainResidueDetails
ATHR35
BTHR35

Catalytic Information from CSA
site_idCSA1
Number of Residues1
DetailsAnnotated By Reference To The Literature 1ksj
ChainResidueDetails
ALEU61

site_idCSA2
Number of Residues1
DetailsAnnotated By Reference To The Literature 1ksj
ChainResidueDetails
BLEU61

site_idCSA3
Number of Residues1
DetailsAnnotated By Reference To The Literature 1ksj
ChainResidueDetails
AALA13

site_idCSA4
Number of Residues1
DetailsAnnotated By Reference To The Literature 1ksj
ChainResidueDetails
BALA13

222624

PDB entries from 2024-07-17

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