1NF3

Structure of Cdc42 in a complex with the GTPase-binding domain of the cell polarity protein, Par6

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000139	cellular_component	Golgi membrane
A	0000166	molecular_function	nucleotide binding
A	0000322	cellular_component	storage vacuole
A	0003015	biological_process	heart process
A	0003253	biological_process	cardiac neural crest cell migration involved in outflow tract morphogenesis
A	0003924	molecular_function	GTPase activity
A	0003925	molecular_function	G protein activity
A	0005515	molecular_function	protein binding
A	0005525	molecular_function	GTP binding
A	0005737	cellular_component	cytoplasm
A	0005789	cellular_component	endoplasmic reticulum membrane
A	0005813	cellular_component	centrosome
A	0005819	cellular_component	spindle
A	0005829	cellular_component	cytosol
A	0005886	cellular_component	plasma membrane
A	0005911	cellular_component	cell-cell junction
A	0005925	cellular_component	focal adhesion
A	0006897	biological_process	endocytosis
A	0006911	biological_process	phagocytosis, engulfment
A	0007015	biological_process	actin filament organization
A	0007030	biological_process	Golgi organization
A	0007163	biological_process	establishment or maintenance of cell polarity
A	0007165	biological_process	signal transduction
A	0007229	biological_process	integrin-mediated signaling pathway
A	0007264	biological_process	small GTPase-mediated signal transduction
A	0007399	biological_process	nervous system development
A	0009653	biological_process	anatomical structure morphogenesis
A	0010591	biological_process	regulation of lamellipodium assembly
A	0010592	biological_process	positive regulation of lamellipodium assembly
A	0015630	cellular_component	microtubule cytoskeleton
A	0016020	cellular_component	membrane
A	0016787	molecular_function	hydrolase activity
A	0017119	cellular_component	Golgi transport complex
A	0019901	molecular_function	protein kinase binding
A	0021762	biological_process	substantia nigra development
A	0030010	biological_process	establishment of cell polarity
A	0030036	biological_process	actin cytoskeleton organization
A	0030154	biological_process	cell differentiation
A	0030175	cellular_component	filopodium
A	0030225	biological_process	macrophage differentiation
A	0030307	biological_process	positive regulation of cell growth
A	0030335	biological_process	positive regulation of cell migration
A	0030425	cellular_component	dendrite
A	0030496	cellular_component	midbody
A	0030742	molecular_function	GTP-dependent protein binding
A	0031252	cellular_component	cell leading edge
A	0031256	cellular_component	leading edge membrane
A	0031274	biological_process	positive regulation of pseudopodium assembly
A	0031333	biological_process	negative regulation of protein-containing complex assembly
A	0031996	molecular_function	thioesterase binding
A	0032427	molecular_function	GBD domain binding
A	0032467	biological_process	positive regulation of cytokinesis
A	0032956	biological_process	regulation of actin cytoskeleton organization
A	0032991	cellular_component	protein-containing complex
A	0034191	molecular_function	apolipoprotein A-I receptor binding
A	0034329	biological_process	cell junction assembly
A	0035050	biological_process	embryonic heart tube development
A	0036464	cellular_component	cytoplasmic ribonucleoprotein granule
A	0038189	biological_process	neuropilin signaling pathway
A	0042802	molecular_function	identical protein binding
A	0042995	cellular_component	cell projection
A	0043005	cellular_component	neuron projection
A	0043025	cellular_component	neuronal cell body
A	0044788	biological_process	host-mediated perturbation of viral process
A	0045177	cellular_component	apical part of cell
A	0045198	biological_process	establishment of epithelial cell apical/basal polarity
A	0045335	cellular_component	phagocytic vesicle
A	0048549	biological_process	positive regulation of pinocytosis
A	0051130	biological_process	positive regulation of cellular component organization
A	0051233	cellular_component	spindle midzone
A	0051489	biological_process	regulation of filopodium assembly
A	0051491	biological_process	positive regulation of filopodium assembly
A	0051492	biological_process	regulation of stress fiber assembly
A	0051496	biological_process	positive regulation of stress fiber assembly
A	0051683	biological_process	establishment of Golgi localization
A	0051988	biological_process	regulation of attachment of spindle microtubules to kinetochore
A	0060071	biological_process	Wnt signaling pathway, planar cell polarity pathway
A	0060501	biological_process	positive regulation of epithelial cell proliferation involved in lung morphogenesis
A	0060997	biological_process	dendritic spine morphogenesis
A	0061630	molecular_function	ubiquitin protein ligase activity
A	0070062	cellular_component	extracellular exosome
A	0071944	cellular_component	cell periphery
A	0072384	biological_process	organelle transport along microtubule
A	0072686	cellular_component	mitotic spindle
A	0086100	biological_process	endothelin receptor signaling pathway
A	0098794	cellular_component	postsynapse
A	0098978	cellular_component	glutamatergic synapse
A	0099175	biological_process	regulation of postsynapse organization
A	1900026	biological_process	positive regulation of substrate adhesion-dependent cell spreading
B	0000139	cellular_component	Golgi membrane
B	0000166	molecular_function	nucleotide binding
B	0000322	cellular_component	storage vacuole
B	0003015	biological_process	heart process
B	0003253	biological_process	cardiac neural crest cell migration involved in outflow tract morphogenesis
B	0003924	molecular_function	GTPase activity
B	0003925	molecular_function	G protein activity
B	0005515	molecular_function	protein binding
B	0005525	molecular_function	GTP binding
B	0005737	cellular_component	cytoplasm
B	0005789	cellular_component	endoplasmic reticulum membrane
B	0005813	cellular_component	centrosome
B	0005819	cellular_component	spindle
B	0005829	cellular_component	cytosol
B	0005886	cellular_component	plasma membrane
B	0005911	cellular_component	cell-cell junction
B	0005925	cellular_component	focal adhesion
B	0006897	biological_process	endocytosis
B	0006911	biological_process	phagocytosis, engulfment
B	0007015	biological_process	actin filament organization
B	0007030	biological_process	Golgi organization
B	0007163	biological_process	establishment or maintenance of cell polarity
B	0007165	biological_process	signal transduction
B	0007229	biological_process	integrin-mediated signaling pathway
B	0007264	biological_process	small GTPase-mediated signal transduction
B	0007399	biological_process	nervous system development
B	0009653	biological_process	anatomical structure morphogenesis
B	0010591	biological_process	regulation of lamellipodium assembly
B	0010592	biological_process	positive regulation of lamellipodium assembly
B	0015630	cellular_component	microtubule cytoskeleton
B	0016020	cellular_component	membrane
B	0016787	molecular_function	hydrolase activity
B	0017119	cellular_component	Golgi transport complex
B	0019901	molecular_function	protein kinase binding
B	0021762	biological_process	substantia nigra development
B	0030010	biological_process	establishment of cell polarity
B	0030036	biological_process	actin cytoskeleton organization
B	0030154	biological_process	cell differentiation
B	0030175	cellular_component	filopodium
B	0030225	biological_process	macrophage differentiation
B	0030307	biological_process	positive regulation of cell growth
B	0030335	biological_process	positive regulation of cell migration
B	0030425	cellular_component	dendrite
B	0030496	cellular_component	midbody
B	0030742	molecular_function	GTP-dependent protein binding
B	0031252	cellular_component	cell leading edge
B	0031256	cellular_component	leading edge membrane
B	0031274	biological_process	positive regulation of pseudopodium assembly
B	0031333	biological_process	negative regulation of protein-containing complex assembly
B	0031996	molecular_function	thioesterase binding
B	0032427	molecular_function	GBD domain binding
B	0032467	biological_process	positive regulation of cytokinesis
B	0032956	biological_process	regulation of actin cytoskeleton organization
B	0032991	cellular_component	protein-containing complex
B	0034191	molecular_function	apolipoprotein A-I receptor binding
B	0034329	biological_process	cell junction assembly
B	0035050	biological_process	embryonic heart tube development
B	0036464	cellular_component	cytoplasmic ribonucleoprotein granule
B	0038189	biological_process	neuropilin signaling pathway
B	0042802	molecular_function	identical protein binding
B	0042995	cellular_component	cell projection
B	0043005	cellular_component	neuron projection
B	0043025	cellular_component	neuronal cell body
B	0044788	biological_process	host-mediated perturbation of viral process
B	0045177	cellular_component	apical part of cell
B	0045198	biological_process	establishment of epithelial cell apical/basal polarity
B	0045335	cellular_component	phagocytic vesicle
B	0048549	biological_process	positive regulation of pinocytosis
B	0051130	biological_process	positive regulation of cellular component organization
B	0051233	cellular_component	spindle midzone
B	0051489	biological_process	regulation of filopodium assembly
B	0051491	biological_process	positive regulation of filopodium assembly
B	0051492	biological_process	regulation of stress fiber assembly
B	0051496	biological_process	positive regulation of stress fiber assembly
B	0051683	biological_process	establishment of Golgi localization
B	0051988	biological_process	regulation of attachment of spindle microtubules to kinetochore
B	0060071	biological_process	Wnt signaling pathway, planar cell polarity pathway
B	0060501	biological_process	positive regulation of epithelial cell proliferation involved in lung morphogenesis
B	0060997	biological_process	dendritic spine morphogenesis
B	0061630	molecular_function	ubiquitin protein ligase activity
B	0070062	cellular_component	extracellular exosome
B	0071944	cellular_component	cell periphery
B	0072384	biological_process	organelle transport along microtubule
B	0072686	cellular_component	mitotic spindle
B	0086100	biological_process	endothelin receptor signaling pathway
B	0098794	cellular_component	postsynapse
B	0098978	cellular_component	glutamatergic synapse
B	0099175	biological_process	regulation of postsynapse organization
B	1900026	biological_process	positive regulation of substrate adhesion-dependent cell spreading

Functional Information from PDB Data

site_id	AC1
Number of Residues	5
Details	BINDING SITE FOR RESIDUE MG A 201

Chain	Residue
A	THR17
A	THR35
A	GNP200
A	HOH500
A	HOH501

---

site_id	AC2
Number of Residues	5
Details	BINDING SITE FOR RESIDUE MG B 203

Chain	Residue
B	HOH503
B	THR17
B	THR35
B	GNP202
B	HOH502

---

site_id	AC3
Number of Residues	25
Details	BINDING SITE FOR RESIDUE GNP A 200

Chain	Residue
A	GLY12
A	ALA13
A	VAL14
A	GLY15
A	LYS16
A	THR17
A	CYS18
A	PHE28
A	TYR32
A	PRO34
A	THR35
A	GLY60
A	GLN116
A	ASP118
A	LEU119
A	SER158
A	ALA159
A	LEU160
A	MG201
A	HOH500
A	HOH501
A	HOH511
A	HOH534
A	HOH617
A	HOH805

---

site_id	AC4
Number of Residues	26
Details	BINDING SITE FOR RESIDUE GNP B 202

Chain	Residue
B	ASP11
B	GLY12
B	ALA13
B	VAL14
B	GLY15
B	LYS16
B	THR17
B	CYS18
B	PHE28
B	SER30
B	TYR32
B	PRO34
B	THR35
B	GLY60
B	GLN116
B	ASP118
B	LEU119
B	SER158
B	ALA159
B	LEU160
B	MG203
B	HOH502
B	HOH503
B	HOH510
B	HOH557
B	HOH580

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	16
Details	Motif: {"description":"Effector region","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	20
Details	Binding site: {}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	8
Details	Binding site: {"evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	2
Details	Modified residue: {"description":"(Microbial infection) O-AMP-tyrosine; by Haemophilus IbpA; alternate","evidences":[{"source":"PubMed","id":"19362538","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"20622875","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	2
Details	Modified residue: {"description":"(Microbial infection) O-AMP-threonine; by Vibrio VopS","evidences":[{"source":"PubMed","id":"19039103","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	2
Details	Modified residue: {"description":"Phosphotyrosine; by SRC","evidences":[{"source":"PubMed","id":"14506284","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	2
Details	Modified residue: {"description":"Cysteine methyl ester","evidences":[{"source":"PubMed","id":"10676816","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1DOA","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	2
Details	Lipidation: {"description":"S-geranylgeranyl cysteine","evidences":[{"source":"PubMed","id":"10676816","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1DOA","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI9
Number of Residues	2
Details	Glycosylation: {"description":"(Microbial infection) O-linked (GlcNAc) tyrosine; by Photorhabdus PAU_02230; alternate","evidences":[{"source":"PubMed","id":"24141704","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI10
Number of Residues	2
Details	Glycosylation: {"description":"(Microbial infection) O-linked (Glc) threonine; by C.difficile toxins TcdA and TcdB; alternate","evidences":[{"source":"PubMed","id":"24905543","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"7775453","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"7777059","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI11
Number of Residues	34
Details	Domain: {"description":"Pseudo-CRIB"}

Chain

Residue

Details

---

site_id	SWS_FT_FI12
Number of Residues	186
Details	Domain: {"description":"PDZ","evidences":[{"source":"PROSITE-ProRule","id":"PRU00143","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

Catalytic Information from CSA

site_id	CSA1
Number of Residues	1
Details	Annotated By Reference To The Literature 1ksj

Chain	Residue	Details
A	LEU61

---

site_id	CSA2
Number of Residues	1
Details	Annotated By Reference To The Literature 1ksj

Chain	Residue	Details
B	LEU61

---

site_id	CSA3
Number of Residues	1
Details	Annotated By Reference To The Literature 1ksj

Chain	Residue	Details
A	ALA13

---

site_id	CSA4
Number of Residues	1
Details	Annotated By Reference To The Literature 1ksj

Chain	Residue	Details
B	ALA13

---