Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

1NE7

HUMAN GLUCOSAMINE-6-PHOSPHATE DEAMINASE ISOMERASE AT 1.75 A RESOLUTION COMPLEXED WITH N-ACETYL-GLUCOSAMINE-6-PHOSPHATE AND 2-DEOXY-2-AMINO-GLUCITOL-6-PHOSPHATE

Replaces: 1D9T

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004342	molecular_function	glucosamine-6-phosphate deaminase activity
A	0005515	molecular_function	protein binding
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0005975	biological_process	carbohydrate metabolic process
A	0006043	biological_process	glucosamine catabolic process
A	0006044	biological_process	N-acetylglucosamine metabolic process
A	0006046	biological_process	N-acetylglucosamine catabolic process
A	0006048	biological_process	UDP-N-acetylglucosamine biosynthetic process
A	0006091	biological_process	generation of precursor metabolites and energy
A	0007338	biological_process	single fertilization
A	0016787	molecular_function	hydrolase activity
A	0016853	molecular_function	isomerase activity
A	0019262	biological_process	N-acetylneuraminate catabolic process
A	0042802	molecular_function	identical protein binding
A	0070062	cellular_component	extracellular exosome
B	0004342	molecular_function	glucosamine-6-phosphate deaminase activity
B	0005515	molecular_function	protein binding
B	0005737	cellular_component	cytoplasm
B	0005829	cellular_component	cytosol
B	0005975	biological_process	carbohydrate metabolic process
B	0006043	biological_process	glucosamine catabolic process
B	0006044	biological_process	N-acetylglucosamine metabolic process
B	0006046	biological_process	N-acetylglucosamine catabolic process
B	0006048	biological_process	UDP-N-acetylglucosamine biosynthetic process
B	0006091	biological_process	generation of precursor metabolites and energy
B	0007338	biological_process	single fertilization
B	0016787	molecular_function	hydrolase activity
B	0016853	molecular_function	isomerase activity
B	0019262	biological_process	N-acetylneuraminate catabolic process
B	0042802	molecular_function	identical protein binding
B	0070062	cellular_component	extracellular exosome
C	0004342	molecular_function	glucosamine-6-phosphate deaminase activity
C	0005515	molecular_function	protein binding
C	0005737	cellular_component	cytoplasm
C	0005829	cellular_component	cytosol
C	0005975	biological_process	carbohydrate metabolic process
C	0006043	biological_process	glucosamine catabolic process
C	0006044	biological_process	N-acetylglucosamine metabolic process
C	0006046	biological_process	N-acetylglucosamine catabolic process
C	0006048	biological_process	UDP-N-acetylglucosamine biosynthetic process
C	0006091	biological_process	generation of precursor metabolites and energy
C	0007338	biological_process	single fertilization
C	0016787	molecular_function	hydrolase activity
C	0016853	molecular_function	isomerase activity
C	0019262	biological_process	N-acetylneuraminate catabolic process
C	0042802	molecular_function	identical protein binding
C	0070062	cellular_component	extracellular exosome
D	0004342	molecular_function	glucosamine-6-phosphate deaminase activity
D	0005515	molecular_function	protein binding
D	0005737	cellular_component	cytoplasm
D	0005829	cellular_component	cytosol
D	0005975	biological_process	carbohydrate metabolic process
D	0006043	biological_process	glucosamine catabolic process
D	0006044	biological_process	N-acetylglucosamine metabolic process
D	0006046	biological_process	N-acetylglucosamine catabolic process
D	0006048	biological_process	UDP-N-acetylglucosamine biosynthetic process
D	0006091	biological_process	generation of precursor metabolites and energy
D	0007338	biological_process	single fertilization
D	0016787	molecular_function	hydrolase activity
D	0016853	molecular_function	isomerase activity
D	0019262	biological_process	N-acetylneuraminate catabolic process
D	0042802	molecular_function	identical protein binding
D	0070062	cellular_component	extracellular exosome
E	0004342	molecular_function	glucosamine-6-phosphate deaminase activity
E	0005515	molecular_function	protein binding
E	0005737	cellular_component	cytoplasm
E	0005829	cellular_component	cytosol
E	0005975	biological_process	carbohydrate metabolic process
E	0006043	biological_process	glucosamine catabolic process
E	0006044	biological_process	N-acetylglucosamine metabolic process
E	0006046	biological_process	N-acetylglucosamine catabolic process
E	0006048	biological_process	UDP-N-acetylglucosamine biosynthetic process
E	0006091	biological_process	generation of precursor metabolites and energy
E	0007338	biological_process	single fertilization
E	0016787	molecular_function	hydrolase activity
E	0016853	molecular_function	isomerase activity
E	0019262	biological_process	N-acetylneuraminate catabolic process
E	0042802	molecular_function	identical protein binding
E	0070062	cellular_component	extracellular exosome
F	0004342	molecular_function	glucosamine-6-phosphate deaminase activity
F	0005515	molecular_function	protein binding
F	0005737	cellular_component	cytoplasm
F	0005829	cellular_component	cytosol
F	0005975	biological_process	carbohydrate metabolic process
F	0006043	biological_process	glucosamine catabolic process
F	0006044	biological_process	N-acetylglucosamine metabolic process
F	0006046	biological_process	N-acetylglucosamine catabolic process
F	0006048	biological_process	UDP-N-acetylglucosamine biosynthetic process
F	0006091	biological_process	generation of precursor metabolites and energy
F	0007338	biological_process	single fertilization
F	0016787	molecular_function	hydrolase activity
F	0016853	molecular_function	isomerase activity
F	0019262	biological_process	N-acetylneuraminate catabolic process
F	0042802	molecular_function	identical protein binding
F	0070062	cellular_component	extracellular exosome

Functional Information from PROSITE/UniProt

site_id	PS01161
Number of Residues	19
Details	GLC_GALNAC_ISOMERASE Glucosamine/galactosamine-6-phosphate isomerases signature. IkaaGgIeLfVgGIGpDGH

Chain	Residue	Details
A	ILE125-HIS143

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	6
Details	ACT_SITE: Proton acceptor; for enolization step => ECO:0000250

Chain	Residue	Details
A	ASP72
B	ASP72
C	ASP72
D	ASP72
E	ASP72
F	ASP72

site_id	SWS_FT_FI2
Number of Residues	12
Details	ACT_SITE: For ring-opening step => ECO:0000250

Chain	Residue	Details
A	ASP141
E	GLU148
F	ASP141
F	GLU148
A	GLU148
B	ASP141
B	GLU148
C	ASP141
C	GLU148
D	ASP141
D	GLU148
E	ASP141

site_id	SWS_FT_FI3
Number of Residues	6
Details	ACT_SITE: Proton acceptor; for ring-opening step => ECO:0000250

Chain	Residue	Details
A	HIS143
B	HIS143
C	HIS143
D	HIS143
E	HIS143
F	HIS143

site_id	SWS_FT_FI4
Number of Residues	6
Details	MOD_RES: N6-acetyllysine => ECO:0007744\|PubMed:19608861

Chain	Residue	Details
A	LYS64
B	LYS64
C	LYS64
D	LYS64
E	LYS64
F	LYS64

site_id	SWS_FT_FI5
Number of Residues	6
Details	MOD_RES: Phosphothreonine => ECO:0000250\|UniProtKB:O88958

Chain	Residue	Details
A	THR161
B	THR161
C	THR161
D	THR161
E	THR161
F	THR161

Catalytic Information from CSA

site_id	CSA1
Number of Residues	4
Details	Annotated By Reference To The Literature 1cd5

Chain	Residue	Details
A	HIS143
A	GLU148
A	ASP141
A	ASP72

site_id	CSA2
Number of Residues	4
Details	Annotated By Reference To The Literature 1cd5

Chain	Residue	Details
B	HIS143
B	GLU148
B	ASP141
B	ASP72

site_id	CSA3
Number of Residues	4
Details	Annotated By Reference To The Literature 1cd5

Chain	Residue	Details
C	HIS143
C	GLU148
C	ASP141
C	ASP72

site_id	CSA4
Number of Residues	4
Details	Annotated By Reference To The Literature 1cd5

Chain	Residue	Details
D	HIS143
D	GLU148
D	ASP141
D	ASP72

site_id	CSA5
Number of Residues	4
Details	Annotated By Reference To The Literature 1cd5

Chain	Residue	Details
E	HIS143
E	GLU148
E	ASP141
E	ASP72

site_id	CSA6
Number of Residues	4
Details	Annotated By Reference To The Literature 1cd5

Chain	Residue	Details
F	HIS143
F	GLU148
F	ASP141
F	ASP72

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)