1NDD

STRUCTURE OF NEDD8

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005515	molecular_function	protein binding
A	0005634	cellular_component	nucleus
A	0005654	cellular_component	nucleoplasm
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0006357	biological_process	regulation of transcription by RNA polymerase II
A	0006508	biological_process	proteolysis
A	0006511	biological_process	ubiquitin-dependent protein catabolic process
A	0008104	biological_process	intracellular protein localization
A	0009653	biological_process	anatomical structure morphogenesis
A	0016567	biological_process	protein ubiquitination
A	0019941	biological_process	modification-dependent protein catabolic process
A	0030162	biological_process	regulation of proteolysis
A	0031386	molecular_function	protein tag activity
A	0031625	molecular_function	ubiquitin protein ligase binding
A	0036211	biological_process	protein modification process
A	0045116	biological_process	protein neddylation
A	0070062	cellular_component	extracellular exosome
A	0072757	biological_process	cellular response to camptothecin
A	0098794	cellular_component	postsynapse
A	0098978	cellular_component	glutamatergic synapse
A	0150052	biological_process	regulation of postsynapse assembly
B	0005515	molecular_function	protein binding
B	0005634	cellular_component	nucleus
B	0005654	cellular_component	nucleoplasm
B	0005737	cellular_component	cytoplasm
B	0005829	cellular_component	cytosol
B	0006357	biological_process	regulation of transcription by RNA polymerase II
B	0006508	biological_process	proteolysis
B	0006511	biological_process	ubiquitin-dependent protein catabolic process
B	0008104	biological_process	intracellular protein localization
B	0009653	biological_process	anatomical structure morphogenesis
B	0016567	biological_process	protein ubiquitination
B	0019941	biological_process	modification-dependent protein catabolic process
B	0030162	biological_process	regulation of proteolysis
B	0031386	molecular_function	protein tag activity
B	0031625	molecular_function	ubiquitin protein ligase binding
B	0036211	biological_process	protein modification process
B	0045116	biological_process	protein neddylation
B	0070062	cellular_component	extracellular exosome
B	0072757	biological_process	cellular response to camptothecin
B	0098794	cellular_component	postsynapse
B	0098978	cellular_component	glutamatergic synapse
B	0150052	biological_process	regulation of postsynapse assembly
C	0005515	molecular_function	protein binding
C	0005634	cellular_component	nucleus
C	0005654	cellular_component	nucleoplasm
C	0005737	cellular_component	cytoplasm
C	0005829	cellular_component	cytosol
C	0006357	biological_process	regulation of transcription by RNA polymerase II
C	0006508	biological_process	proteolysis
C	0006511	biological_process	ubiquitin-dependent protein catabolic process
C	0008104	biological_process	intracellular protein localization
C	0009653	biological_process	anatomical structure morphogenesis
C	0016567	biological_process	protein ubiquitination
C	0019941	biological_process	modification-dependent protein catabolic process
C	0030162	biological_process	regulation of proteolysis
C	0031386	molecular_function	protein tag activity
C	0031625	molecular_function	ubiquitin protein ligase binding
C	0036211	biological_process	protein modification process
C	0045116	biological_process	protein neddylation
C	0070062	cellular_component	extracellular exosome
C	0072757	biological_process	cellular response to camptothecin
C	0098794	cellular_component	postsynapse
C	0098978	cellular_component	glutamatergic synapse
C	0150052	biological_process	regulation of postsynapse assembly
D	0005515	molecular_function	protein binding
D	0005634	cellular_component	nucleus
D	0005654	cellular_component	nucleoplasm
D	0005737	cellular_component	cytoplasm
D	0005829	cellular_component	cytosol
D	0006357	biological_process	regulation of transcription by RNA polymerase II
D	0006508	biological_process	proteolysis
D	0006511	biological_process	ubiquitin-dependent protein catabolic process
D	0008104	biological_process	intracellular protein localization
D	0009653	biological_process	anatomical structure morphogenesis
D	0016567	biological_process	protein ubiquitination
D	0019941	biological_process	modification-dependent protein catabolic process
D	0030162	biological_process	regulation of proteolysis
D	0031386	molecular_function	protein tag activity
D	0031625	molecular_function	ubiquitin protein ligase binding
D	0036211	biological_process	protein modification process
D	0045116	biological_process	protein neddylation
D	0070062	cellular_component	extracellular exosome
D	0072757	biological_process	cellular response to camptothecin
D	0098794	cellular_component	postsynapse
D	0098978	cellular_component	glutamatergic synapse
D	0150052	biological_process	regulation of postsynapse assembly

Functional Information from PDB Data

site_id	AC1
Number of Residues	3
Details	BINDING SITE FOR RESIDUE CL B 2001

Chain	Residue
B	LEU171
B	HOH1036
C	LEU271

---

site_id	AC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE CL A 2002

Chain	Residue
A	LEU71
A	HOH1054
D	LEU371
D	HOH1068

---

site_id	AC3
Number of Residues	5
Details	BINDING SITE FOR RESIDUE SO4 D 3001

Chain	Residue
D	ARG342
D	GLN349
D	HOH1043
D	LYS327
D	GLN341

---

site_id	AC4
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 C 3002

Chain	Residue
A	SER46
C	ASN251
C	LYS254
C	HOH1088

---

site_id	AC5
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 C 3003

Chain	Residue
C	LYS227
C	ARG242
C	HOH1008
C	HOH1038

---

site_id	AC6
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 C 3004

Chain	Residue
A	LYS48
A	GLN49
C	LYS248
C	LYS260

---

Functional Information from PROSITE/UniProt

site_id	PS00299
Number of Residues	26
Details	UBIQUITIN_1 Ubiquitin domain signature. KerVeEkegIPpqqQrLIYsGkqmnD

Chain	Residue	Details
A	LYS27-ASP52

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	8
Details	Region: {"description":"Interaction with UBE1C","evidences":[{"source":"PubMed","id":"14690597","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	8
Details	Site: {"description":"Interaction with UBE1C","evidences":[{"source":"PubMed","id":"14690597","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	4
Details	Modified residue: {"description":"(Microbial infection) Deamidated glutamine","evidences":[{"source":"PubMed","id":"20688984","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"21903097","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"23175788","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"23589306","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"26632597","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	4
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"UniProtKB","id":"P29595","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	2
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Gly-Lys) (interchain with K-? in acceptor proteins)","evidences":[{"source":"PubMed","id":"38316879","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---