Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

1NDD

STRUCTURE OF NEDD8

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005515	molecular_function	protein binding
A	0005634	cellular_component	nucleus
A	0005654	cellular_component	nucleoplasm
A	0005829	cellular_component	cytosol
A	0006357	biological_process	regulation of transcription by RNA polymerase II
A	0006508	biological_process	proteolysis
A	0006511	biological_process	ubiquitin-dependent protein catabolic process
A	0008104	biological_process	protein localization
A	0009653	biological_process	anatomical structure morphogenesis
A	0016567	biological_process	protein ubiquitination
A	0019941	biological_process	modification-dependent protein catabolic process
A	0030162	biological_process	regulation of proteolysis
A	0031386	molecular_function	protein tag activity
A	0031625	molecular_function	ubiquitin protein ligase binding
A	0036211	biological_process	protein modification process
A	0045116	biological_process	protein neddylation
A	0070062	cellular_component	extracellular exosome
B	0005515	molecular_function	protein binding
B	0005634	cellular_component	nucleus
B	0005654	cellular_component	nucleoplasm
B	0005829	cellular_component	cytosol
B	0006357	biological_process	regulation of transcription by RNA polymerase II
B	0006508	biological_process	proteolysis
B	0006511	biological_process	ubiquitin-dependent protein catabolic process
B	0008104	biological_process	protein localization
B	0009653	biological_process	anatomical structure morphogenesis
B	0016567	biological_process	protein ubiquitination
B	0019941	biological_process	modification-dependent protein catabolic process
B	0030162	biological_process	regulation of proteolysis
B	0031386	molecular_function	protein tag activity
B	0031625	molecular_function	ubiquitin protein ligase binding
B	0036211	biological_process	protein modification process
B	0045116	biological_process	protein neddylation
B	0070062	cellular_component	extracellular exosome
C	0005515	molecular_function	protein binding
C	0005634	cellular_component	nucleus
C	0005654	cellular_component	nucleoplasm
C	0005829	cellular_component	cytosol
C	0006357	biological_process	regulation of transcription by RNA polymerase II
C	0006508	biological_process	proteolysis
C	0006511	biological_process	ubiquitin-dependent protein catabolic process
C	0008104	biological_process	protein localization
C	0009653	biological_process	anatomical structure morphogenesis
C	0016567	biological_process	protein ubiquitination
C	0019941	biological_process	modification-dependent protein catabolic process
C	0030162	biological_process	regulation of proteolysis
C	0031386	molecular_function	protein tag activity
C	0031625	molecular_function	ubiquitin protein ligase binding
C	0036211	biological_process	protein modification process
C	0045116	biological_process	protein neddylation
C	0070062	cellular_component	extracellular exosome
D	0005515	molecular_function	protein binding
D	0005634	cellular_component	nucleus
D	0005654	cellular_component	nucleoplasm
D	0005829	cellular_component	cytosol
D	0006357	biological_process	regulation of transcription by RNA polymerase II
D	0006508	biological_process	proteolysis
D	0006511	biological_process	ubiquitin-dependent protein catabolic process
D	0008104	biological_process	protein localization
D	0009653	biological_process	anatomical structure morphogenesis
D	0016567	biological_process	protein ubiquitination
D	0019941	biological_process	modification-dependent protein catabolic process
D	0030162	biological_process	regulation of proteolysis
D	0031386	molecular_function	protein tag activity
D	0031625	molecular_function	ubiquitin protein ligase binding
D	0036211	biological_process	protein modification process
D	0045116	biological_process	protein neddylation
D	0070062	cellular_component	extracellular exosome

Functional Information from PDB Data

site_id	AC1
Number of Residues	3
Details	BINDING SITE FOR RESIDUE CL B 2001

Chain	Residue
B	LEU171
B	HOH1036
C	LEU271

site_id	AC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE CL A 2002

Chain	Residue
A	LEU71
A	HOH1054
D	LEU371
D	HOH1068

site_id	AC3
Number of Residues	5
Details	BINDING SITE FOR RESIDUE SO4 D 3001

Chain	Residue
D	ARG342
D	GLN349
D	HOH1043
D	LYS327
D	GLN341

site_id	AC4
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 C 3002

Chain	Residue
A	SER46
C	ASN251
C	LYS254
C	HOH1088

site_id	AC5
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 C 3003

Chain	Residue
C	LYS227
C	ARG242
C	HOH1008
C	HOH1038

site_id	AC6
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 C 3004

Chain	Residue
A	LYS48
A	GLN49
C	LYS248
C	LYS260

Functional Information from PROSITE/UniProt

site_id	PS00299
Number of Residues	26
Details	UBIQUITIN_1 Ubiquitin domain signature. KerVeEkegIPpqqQrLIYsGkqmnD

Chain	Residue	Details
A	LYS27-ASP52

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	8
Details	SITE: Interaction with UBE1C => ECO:0000269\|PubMed:14690597

Chain	Residue	Details
A	LEU8
A	ILE44
B	LEU108
B	ILE144
C	LEU208
C	ILE244
D	LEU308
D	ILE344

site_id	SWS_FT_FI2
Number of Residues	4
Details	MOD_RES: (Microbial infection) Deamidated glutamine => ECO:0000269\|PubMed:20688984, ECO:0000269\|PubMed:21903097, ECO:0000269\|PubMed:23175788, ECO:0000269\|PubMed:23589306, ECO:0000269\|PubMed:26632597

Chain	Residue	Details
A	GLN40
B	GLN140
C	GLN240
D	GLN340

site_id	SWS_FT_FI3
Number of Residues	4
Details	MOD_RES: N6-acetyllysine => ECO:0000250\|UniProtKB:P29595

Chain	Residue	Details
A	LYS48
B	LYS148
C	LYS248
D	LYS348

site_id	SWS_FT_FI4
Number of Residues	8
Details	CROSSLNK: Glycyl lysine isopeptide (Gly-Lys) (interchain with K-? in acceptor proteins)

Chain	Residue	Details
A	GLY76
B	GLY176
C	GLY276
D	GLY376

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)