1NCF

A NEW PARADIGM FOR TUMOR NECROSIS FACTOR SIGNALLING

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005031	molecular_function	tumor necrosis factor receptor activity
A	0006693	biological_process	prostaglandin metabolic process
A	0006954	biological_process	inflammatory response
A	0033209	biological_process	tumor necrosis factor-mediated signaling pathway
B	0005031	molecular_function	tumor necrosis factor receptor activity
B	0006693	biological_process	prostaglandin metabolic process
B	0006954	biological_process	inflammatory response
B	0033209	biological_process	tumor necrosis factor-mediated signaling pathway

Functional Information from PROSITE/UniProt

site_id	PS00652
Number of Residues	38
Details	TNFR_NGFR_1 TNFR/NGFR family cysteine-rich region signature. CpqgkyiHpqnnsi....C..Ctk.Chkgtylynd..Cpgpgq.DTDC

Chain	Residue	Details
A	CYS15-CYS52
A	CYS55-CYS96
A	CYS96-CYS137

---

site_id	PS01186
Number of Residues	14
Details	EGF_2 EGF-like domain signature 2. CtChaGFflrene..C

Chain	Residue	Details
A	CYS137-CYS150

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	78
Details	Repeat: {"description":"TNFR-Cys 1"}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	84
Details	Repeat: {"description":"TNFR-Cys 2"}

Chain

Residue

Details

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site_id	SWS_FT_FI3
Number of Residues	80
Details	Repeat: {"description":"TNFR-Cys 3"}

Chain

Residue

Details

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site_id	SWS_FT_FI4
Number of Residues	6
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

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