1N94
Aryl Tetrahydropyridine Inhbitors of Farnesyltransferase: Glycine, Phenylalanine and Histidine Derivates
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0008318 | molecular_function | protein prenyltransferase activity |
| A | 0018342 | biological_process | protein prenylation |
| B | 0003824 | molecular_function | catalytic activity |
| B | 0004311 | molecular_function | farnesyltranstransferase activity |
| B | 0004659 | molecular_function | prenyltransferase activity |
| B | 0004660 | molecular_function | protein farnesyltransferase activity |
| B | 0005515 | molecular_function | protein binding |
| B | 0005875 | cellular_component | microtubule associated complex |
| B | 0005965 | cellular_component | protein farnesyltransferase complex |
| B | 0006629 | biological_process | lipid metabolic process |
| B | 0008270 | molecular_function | zinc ion binding |
| B | 0008283 | biological_process | cell population proliferation |
| B | 0008284 | biological_process | positive regulation of cell population proliferation |
| B | 0008285 | biological_process | negative regulation of cell population proliferation |
| B | 0008318 | molecular_function | protein prenyltransferase activity |
| B | 0014070 | biological_process | response to organic cyclic compound |
| B | 0018343 | biological_process | protein farnesylation |
| B | 0034097 | biological_process | response to cytokine |
| B | 0042060 | biological_process | wound healing |
| B | 0042277 | molecular_function | peptide binding |
| B | 0045787 | biological_process | positive regulation of cell cycle |
| B | 0046872 | molecular_function | metal ion binding |
| B | 0048144 | biological_process | fibroblast proliferation |
| B | 0048145 | biological_process | regulation of fibroblast proliferation |
| B | 0048146 | biological_process | positive regulation of fibroblast proliferation |
| B | 0051770 | biological_process | positive regulation of nitric-oxide synthase biosynthetic process |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE ZN B 2 |
| Chain | Residue |
| B | ASP297 |
| B | CYS299 |
| B | HIS362 |
| site_id | AC2 |
| Number of Residues | 10 |
| Details | BINDING SITE FOR RESIDUE HFP A 501 |
| Chain | Residue |
| B | ARG202 |
| B | HIS248 |
| B | GLY250 |
| B | CYS254 |
| A | TIN1 |
| A | LYS164 |
| A | TYR166 |
| A | ASN199 |
| A | TYR200 |
| A | HIS201 |
| site_id | AC3 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE TIN A 1 |
| Chain | Residue |
| A | LYS164 |
| A | TYR166 |
| A | GLN167 |
| A | HFP501 |
| B | ALA98 |
| B | SER99 |
| B | TRP106 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 3 |
| Details | BINDING: |
| Chain | Residue | Details |
| B | HIS248 | |
| B | ARG291 | |
| B | TYR300 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 3 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:18844669, ECO:0000269|PubMed:20056542, ECO:0000269|PubMed:9065406 |
| Chain | Residue | Details |
| B | ASP297 | |
| B | CYS299 | |
| B | HIS362 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 1 |
| Details | SITE: Important for selectivity against geranylgeranyl diphosphate => ECO:0000250|UniProtKB:P49356 |
| Chain | Residue | Details |
| B | TRP102 |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1d8d |
| Chain | Residue | Details |
| A | LYS164 | |
| B | TYR300 |
| site_id | MCSA1 |
| Number of Residues | 9 |
| Details | M-CSA 484 |
| Chain | Residue | Details |
| B | HIS248 | electrostatic stabiliser |
| B | ARG291 | electrostatic stabiliser |
| B | LYS294 | electrostatic stabiliser |
| B | ASP297 | metal ligand |
| B | CYS299 | metal ligand |
| B | TYR300 | electrostatic stabiliser |
| B | ASP352 | metal ligand |
| B | ASP359 | electrostatic stabiliser |
| B | HIS362 | metal ligand |
