1N8S

Structure of the pancreatic lipase-colipase complex

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0001523	biological_process	retinoid metabolic process
A	0004465	molecular_function	lipoprotein lipase activity
A	0004806	molecular_function	triacylglycerol lipase activity
A	0005576	cellular_component	extracellular region
A	0005615	cellular_component	extracellular space
A	0006629	biological_process	lipid metabolic process
A	0006633	biological_process	fatty acid biosynthetic process
A	0008970	molecular_function	phospholipase A1 activity
A	0016042	biological_process	lipid catabolic process
A	0016298	molecular_function	lipase activity
A	0016787	molecular_function	hydrolase activity
A	0019433	biological_process	triglyceride catabolic process
A	0030299	biological_process	intestinal cholesterol absorption
A	0034375	biological_process	high-density lipoprotein particle remodeling
A	0042572	biological_process	retinol metabolic process
A	0042632	biological_process	cholesterol homeostasis
A	0046872	molecular_function	metal ion binding
A	0047376	molecular_function	all-trans-retinyl-palmitate hydrolase, all-trans-retinol forming activity
A	0050253	molecular_function	retinyl-palmitate esterase activity
A	0052689	molecular_function	carboxylic ester hydrolase activity
A	0061365	biological_process	positive regulation of triglyceride lipase activity
C	0001523	biological_process	retinoid metabolic process
C	0005576	cellular_component	extracellular region
C	0006629	biological_process	lipid metabolic process
C	0007586	biological_process	digestion
C	0008047	molecular_function	enzyme activator activity
C	0009617	biological_process	response to bacterium
C	0016042	biological_process	lipid catabolic process
C	0032094	biological_process	response to food
C	0035473	molecular_function	lipase binding
C	0043085	biological_process	positive regulation of catalytic activity

Functional Information from PROSITE/UniProt

site_id	PS00120
Number of Residues	10
Details	LIPASE_SER Lipases, serine active site. VHVIGHSLGA

Chain	Residue	Details
A	VAL146-ALA155

---

site_id	PS00121
Number of Residues	9
Details	COLIPASE_1 Colipase signature. YgvYYkCpC

Chain	Residue	Details
C	TYR555-CYS563

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	110
Details	Domain: {"description":"PLAT","evidences":[{"source":"PROSITE-ProRule","id":"PRU00152","evidenceCode":"ECO:0000255"}]}

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Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	1
Details	Active site: {"description":"Nucleophile"}

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Residue

Details

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site_id	SWS_FT_FI3
Number of Residues	2
Details	Active site: {"description":"Charge relay system"}

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Residue

Details

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site_id	SWS_FT_FI4
Number of Residues	4
Details	Binding site: {}

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site_id	SWS_FT_FI5
Number of Residues	1
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine"}

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Details

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