1N6P

Crystal Structure of Human Rab5a A30E mutant complex with GppNHp

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003924	molecular_function	GTPase activity
A	0005525	molecular_function	GTP binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	5
Details	BINDING SITE FOR RESIDUE MG A 201

Chain	Residue
A	SER34
A	THR52
A	GNP200
A	HOH301
A	HOH302

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site_id	AC2
Number of Residues	30
Details	BINDING SITE FOR RESIDUE GNP A 200

Chain	Residue
A	LYS33
A	SER34
A	SER35
A	PHE45
A	HIS46
A	GLU47
A	GLN49
A	SER51
A	THR52
A	GLY78
A	ASN133
A	LYS134
A	ASP136
A	LEU137
A	SER163
A	ALA164
A	LYS165
A	LYS180
A	MG201
A	HOH301
A	HOH302
A	HOH303
A	HOH304
A	HOH333
A	HOH341
A	HOH400
A	SER29
A	GLU30
A	VAL31
A	GLY32

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	5
Details	BINDING: BINDING => ECO:0000269|PubMed:12433916, ECO:0000269|PubMed:14684892, ECO:0000269|PubMed:15378032, ECO:0000269|PubMed:20534488, ECO:0007744|PDB:1N6H, ECO:0007744|PDB:1N6L, ECO:0007744|PDB:1N6N, ECO:0007744|PDB:1N6O, ECO:0007744|PDB:1N6P, ECO:0007744|PDB:1N6R, ECO:0007744|PDB:1R2Q, ECO:0007744|PDB:1TU3, ECO:0007744|PDB:3MJH

Chain	Residue	Details
A	GLY27
A	HIS46
A	ASP75
A	ASN133
A	SER163

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site_id	SWS_FT_FI2
Number of Residues	1
Details	MOD_RES: Phosphoserine; by LRRK2 => ECO:0000269|PubMed:29125462

Chain	Residue	Details
A	SER84

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site_id	SWS_FT_FI3
Number of Residues	1
Details	CARBOHYD: (Microbial infection) N-beta-linked (GlcNAc) arginine => ECO:0000269|PubMed:32974215

Chain	Residue	Details
A	ARG120

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Catalytic Information from CSA

site_id	CSA1
Number of Residues	1
Details	Annotated By Reference To The Literature 1ksj

Chain	Residue	Details
A	GLN79

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site_id	CSA2
Number of Residues	1
Details	Annotated By Reference To The Literature 1ksj

Chain	Residue	Details
A	GLU30

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