1N52
Cap Binding Complex
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000184 | biological_process | nuclear-transcribed mRNA catabolic process, nonsense-mediated decay |
| A | 0000245 | biological_process | spliceosomal complex assembly |
| A | 0000339 | molecular_function | RNA cap binding |
| A | 0000340 | molecular_function | RNA 7-methylguanosine cap binding |
| A | 0000380 | biological_process | alternative mRNA splicing, via spliceosome |
| A | 0000398 | biological_process | mRNA splicing, via spliceosome |
| A | 0002191 | biological_process | cap-dependent translational initiation |
| A | 0003723 | molecular_function | RNA binding |
| A | 0003729 | molecular_function | mRNA binding |
| A | 0005515 | molecular_function | protein binding |
| A | 0005634 | cellular_component | nucleus |
| A | 0005654 | cellular_component | nucleoplasm |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005829 | cellular_component | cytosol |
| A | 0005846 | cellular_component | nuclear cap binding complex |
| A | 0006370 | biological_process | 7-methylguanosine mRNA capping |
| A | 0006397 | biological_process | mRNA processing |
| A | 0006401 | biological_process | RNA catabolic process |
| A | 0006406 | biological_process | mRNA export from nucleus |
| A | 0006408 | biological_process | snRNA export from nucleus |
| A | 0006417 | biological_process | regulation of translation |
| A | 0006446 | biological_process | regulation of translational initiation |
| A | 0008334 | biological_process | histone mRNA metabolic process |
| A | 0008380 | biological_process | RNA splicing |
| A | 0016070 | biological_process | RNA metabolic process |
| A | 0016071 | biological_process | mRNA metabolic process |
| A | 0030307 | biological_process | positive regulation of cell growth |
| A | 0031047 | biological_process | regulatory ncRNA-mediated gene silencing |
| A | 0031053 | biological_process | primary miRNA processing |
| A | 0031124 | biological_process | mRNA 3'-end processing |
| A | 0031442 | biological_process | positive regulation of mRNA 3'-end processing |
| A | 0032968 | biological_process | positive regulation of transcription elongation by RNA polymerase II |
| A | 0034518 | cellular_component | RNA cap binding complex |
| A | 0035194 | biological_process | regulatory ncRNA-mediated post-transcriptional gene silencing |
| A | 0035195 | biological_process | miRNA-mediated post-transcriptional gene silencing |
| A | 0042789 | biological_process | mRNA transcription by RNA polymerase II |
| A | 0048026 | biological_process | positive regulation of mRNA splicing, via spliceosome |
| A | 0050684 | biological_process | regulation of mRNA processing |
| A | 0051028 | biological_process | mRNA transport |
| A | 0051607 | biological_process | defense response to virus |
| A | 0060090 | molecular_function | molecular adaptor activity |
| A | 1990904 | cellular_component | ribonucleoprotein complex |
| B | 0000184 | biological_process | nuclear-transcribed mRNA catabolic process, nonsense-mediated decay |
| B | 0000339 | molecular_function | RNA cap binding |
| B | 0000340 | molecular_function | RNA 7-methylguanosine cap binding |
| B | 0000380 | biological_process | alternative mRNA splicing, via spliceosome |
| B | 0000398 | biological_process | mRNA splicing, via spliceosome |
| B | 0002191 | biological_process | cap-dependent translational initiation |
| B | 0003676 | molecular_function | nucleic acid binding |
| B | 0003677 | molecular_function | DNA binding |
| B | 0003723 | molecular_function | RNA binding |
| B | 0003729 | molecular_function | mRNA binding |
| B | 0005515 | molecular_function | protein binding |
| B | 0005634 | cellular_component | nucleus |
| B | 0005654 | cellular_component | nucleoplasm |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0005829 | cellular_component | cytosol |
| B | 0005846 | cellular_component | nuclear cap binding complex |
| B | 0006397 | biological_process | mRNA processing |
| B | 0006406 | biological_process | mRNA export from nucleus |
| B | 0006408 | biological_process | snRNA export from nucleus |
| B | 0006417 | biological_process | regulation of translation |
| B | 0006446 | biological_process | regulation of translational initiation |
| B | 0008334 | biological_process | histone mRNA metabolic process |
| B | 0008380 | biological_process | RNA splicing |
| B | 0016071 | biological_process | mRNA metabolic process |
| B | 0017069 | molecular_function | snRNA binding |
| B | 0031047 | biological_process | regulatory ncRNA-mediated gene silencing |
| B | 0031053 | biological_process | primary miRNA processing |
| B | 0031124 | biological_process | mRNA 3'-end processing |
| B | 0031442 | biological_process | positive regulation of mRNA 3'-end processing |
| B | 0032968 | biological_process | positive regulation of transcription elongation by RNA polymerase II |
| B | 0034518 | cellular_component | RNA cap binding complex |
| B | 0035194 | biological_process | regulatory ncRNA-mediated post-transcriptional gene silencing |
| B | 0035195 | biological_process | miRNA-mediated post-transcriptional gene silencing |
| B | 0042789 | biological_process | mRNA transcription by RNA polymerase II |
| B | 0045292 | biological_process | mRNA cis splicing, via spliceosome |
| B | 0046833 | biological_process | positive regulation of RNA export from nucleus |
| B | 0051028 | biological_process | mRNA transport |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE MG A 6000 |
| Chain | Residue |
| A | LYS707 |
| A | TYR761 |
| A | THR764 |
| site_id | AC2 |
| Number of Residues | 15 |
| Details | BINDING SITE FOR RESIDUE GTG B 2137 |
| Chain | Residue |
| B | ASP116 |
| B | ARG123 |
| B | ARG127 |
| B | GLY128 |
| B | GLN133 |
| B | VAL134 |
| B | ARG135 |
| B | TYR138 |
| B | GOL1574 |
| B | TYR20 |
| B | TYR43 |
| B | PHE83 |
| B | ARG112 |
| B | ASP114 |
| B | TRP115 |
| site_id | AC3 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE PG4 A 3000 |
| Chain | Residue |
| A | PRO388 |
| A | LEU391 |
| A | PHE417 |
| A | HIS420 |
| A | PHE424 |
| A | ARG427 |
| A | HOH6002 |
| site_id | AC4 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE GOL A 1555 |
| Chain | Residue |
| A | ARG458 |
| A | GLN599 |
| A | ALA602 |
| A | GLU639 |
| A | GOL1556 |
| A | HOH6138 |
| B | TYR57 |
| B | GLU58 |
| B | GOL1558 |
| site_id | AC5 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE GOL A 1556 |
| Chain | Residue |
| A | GLU639 |
| A | ARG646 |
| A | GOL1555 |
| B | GOL1558 |
| site_id | AC6 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE GOL A 1557 |
| Chain | Residue |
| A | HOH6006 |
| site_id | AC7 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE GOL B 1558 |
| Chain | Residue |
| A | ASP606 |
| A | SER643 |
| A | GOL1555 |
| A | GOL1556 |
| B | SER61 |
| B | ASP65 |
| B | ILE66 |
| site_id | AC8 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE GOL A 1560 |
| Chain | Residue |
| A | HIS307 |
| site_id | AC9 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE GOL A 1561 |
| Chain | Residue |
| A | TYR126 |
| A | GLU316 |
| A | HIS319 |
| site_id | BC1 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE GOL A 1564 |
| Chain | Residue |
| A | LEU551 |
| A | LEU554 |
| site_id | BC2 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE GOL A 1565 |
| Chain | Residue |
| A | ILE720 |
| A | GLU723 |
| A | HIS724 |
| A | ARG727 |
| A | TRP739 |
| A | HOH6031 |
| site_id | BC3 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE GOL A 1566 |
| Chain | Residue |
| A | ILE623 |
| A | PHE624 |
| A | SER625 |
| A | SER629 |
| A | PHE632 |
| site_id | BC4 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE GOL B 1568 |
| Chain | Residue |
| B | SER48 |
| B | TYR50 |
| B | GLN55 |
| B | ASP107 |
| site_id | BC5 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE GOL A 1569 |
| Chain | Residue |
| A | GLN759 |
| A | PHE785 |
| A | CYS786 |
| A | LEU788 |
| A | GLN789 |
| site_id | BC6 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE GOL B 1570 |
| Chain | Residue |
| B | TYR43 |
| B | GLY45 |
| B | ASN46 |
| B | GLY82 |
| B | ARG112 |
| B | GLN133 |
| B | ARG135 |
| B | ARG146 |
| site_id | BC7 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE GOL B 1571 |
| Chain | Residue |
| B | THR79 |
| B | ALA80 |
| B | HOH2193 |
| site_id | BC8 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE GOL A 1572 |
| Chain | Residue |
| A | ARG450 |
| A | GLU454 |
| A | PRO478 |
| A | ALA479 |
| A | ARG634 |
| A | HOH6014 |
| site_id | BC9 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE GOL A 1573 |
| Chain | Residue |
| A | LEU79 |
| A | LYS82 |
| A | HIS325 |
| A | GLN335 |
| A | HOH6105 |
| site_id | CC1 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE GOL B 1574 |
| Chain | Residue |
| B | ARG129 |
| B | TYR138 |
| B | GTG2137 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 212 |
| Details | Domain: {"description":"MIF4G"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"19608861","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 78 |
| Details | Domain: {"description":"RRM","evidences":[{"source":"PROSITE-ProRule","id":"PRU00176","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 10 |
| Details | Compositional bias: {"description":"Basic and acidic residues","evidences":[{"source":"SAM","id":"MobiDB-lite","evidenceCode":"ECO:0000256"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 2 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"12374755","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"12434151","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 9 |
| Details | Binding site: {} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI8 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"17525332","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI9 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"Omega-N-methylarginine","evidences":[{"source":"PubMed","id":"24129315","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
