1N4U

CHOLESTEROL OXIDASE FROM STREPTOMYCES @ pH 4.5 (STREPTOMYCES SP. SA-COO)

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004769	molecular_function	steroid delta-isomerase activity
A	0005576	cellular_component	extracellular region
A	0006707	biological_process	cholesterol catabolic process
A	0008203	biological_process	cholesterol metabolic process
A	0016491	molecular_function	oxidoreductase activity
A	0016614	molecular_function	oxidoreductase activity, acting on CH-OH group of donors
A	0016853	molecular_function	isomerase activity
A	0016995	molecular_function	cholesterol oxidase activity
A	0050660	molecular_function	flavin adenine dinucleotide binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	10
Details	BINDING SITE FOR RESIDUE PO4 A 511

Chain	Residue
A	GLU179
A	HOH1089
A	GLN180
A	LYS183
A	ARG283
A	HIS331
A	TRP333
A	ASN334
A	HOH684
A	HOH1072

---

site_id	AC2
Number of Residues	12
Details	BINDING SITE FOR RESIDUE PO4 A 512

Chain	Residue
A	ASP139
A	GLU142
A	TYR147
A	TYR461
A	ARG496
A	ARG500
A	HOH581
A	HOH678
A	HOH835
A	HOH1016
A	HOH1095
A	HOH1111

---

site_id	AC3
Number of Residues	3
Details	BINDING SITE FOR RESIDUE PO4 A 513

Chain	Residue
A	ARG146
A	ARG150
A	HOH808

---

site_id	AC4
Number of Residues	4
Details	BINDING SITE FOR RESIDUE PO4 A 514

Chain	Residue
A	ARG254
A	THR256
A	LYS257
A	ASP258

---

site_id	AC5
Number of Residues	8
Details	BINDING SITE FOR RESIDUE PO4 A 515

Chain	Residue
A	GLN245
A	THR246
A	HIS248
A	HOH727
A	HOH840
A	HOH1004
A	HOH1112
A	HOH1197

---

site_id	AC6
Number of Residues	45
Details	BINDING SITE FOR RESIDUE FAE A 510

Chain	Residue
A	ILE16
A	GLY17
A	GLY19
A	TYR20
A	GLY21
A	LEU39
A	GLU40
A	MET41
A	TYR107
A	GLY109
A	ARG110
A	GLY111
A	GLY114
A	GLY115
A	ASN119
A	GLY120
A	GLY121
A	MET122
A	ILE218
A	HIS248
A	GLN249
A	VAL250
A	GLY288
A	ALA289
A	GLY290
A	TYR446
A	HIS447
A	ASP474
A	GLY475
A	ASN485
A	PRO486
A	PHE487
A	ILE490
A	HOH541
A	HOH569
A	HOH594
A	HOH600
A	HOH610
A	HOH623
A	HOH680
A	HOH695
A	HOH934
A	HOH935
A	HOH1078
A	HOH1207

---

site_id	AC7
Number of Residues	9
Details	BINDING SITE FOR RESIDUE OXY A 517

Chain	Residue
A	MET122
A	PHE359
A	ALA360
A	GLU361
A	ILE379
A	ASN485
A	HOH1211
A	HOH1213
A	HOH1215

---

site_id	AC8
Number of Residues	12
Details	BINDING SITE FOR RESIDUE GOL A 516

Chain	Residue
A	HOH883
A	HOH892
A	HOH1029
A	HOH1087
A	LEU76
A	VAL217
A	PRO364
A	LEU375
A	TYR446
A	HOH587
A	HOH706
A	HOH743

---

Functional Information from PROSITE/UniProt

site_id	PS00623
Number of Residues	24
Details	GMC_OXRED_1 GMC oxidoreductases signature 1. GRgVGGGSlVNggmAvePkrsyfE

Chain	Residue	Details
A	GLY109-GLU132

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	ACT_SITE: Proton acceptor => ECO:0000305|PubMed:10194345

Chain	Residue	Details
A	GLU361
A	HIS447

---

site_id	SWS_FT_FI2
Number of Residues	7
Details	BINDING: BINDING => ECO:0007744|PDB:1B4V

Chain	Residue	Details
A	TYR20
A	GLU40
A	GLY115
A	ASN119
A	VAL250
A	GLY475
A	PHE487

---

site_id	SWS_FT_FI3
Number of Residues	1
Details	BINDING: BINDING => ECO:0007744|PDB:1IJH

Chain	Residue	Details
A	TYR446

---

Catalytic Information from CSA

site_id	CSA1
Number of Residues	3
Details	Annotated By Reference To The Literature 1coy

Chain	Residue	Details
A	ASN485
A	GLU361
A	HIS447

---

site_id	CSA2
Number of Residues	2
Details	Annotated By Reference To The Literature 1coy

Chain	Residue	Details
A	ASN485
A	HIS447

---